Phosphorylation of OCT4 Serine 236 Inhibits Germ Cell Tumor Growth by Inducing Differentiation

Phosphorylation of OCT4 Serine 236 Inhibits Germ Cell Tumor Growth by Inducing Differentiation

Octamer-binding transcription factor 4 (Oct4) plays an important role in maintaining pluripotency in embryonic stem cells and is closely related to the malignancies of various cancers. Although posttranslational modifications of Oct4 have been widely studied, most of these have not yet been fully ch...

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Main Authors: Dong-Keon Kim, Bomin Song, Suji Han, Hansol Jang, Seung-Hyun Bae, Hee Yeon Kim, Seon-Hyeong Lee, Seungjin Lee, Jong Kwang Kim, Han-Seong Kim, Kyeong-Man Hong, Byung Il Lee, Hong-Duk Youn, Soo-Youl Kim, Sang Won Kang, Hyonchol Jang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
Oct4
phosphorylation
germ cell tumor
cancer differentiation
OCT4 serine 236
OCT4 inhibitor
Online Access:https://www.mdpi.com/2072-6694/12/9/2601

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