Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. A...

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Main Authors:	Emma Rybalka, Cara A. Timpani, Christos G. Stathis, Alan Hayes, Matthew B. Cooke
Format:	Article
Language:	English
Published:	MDPI AG 2015-11-01
Series:	Nutrients
Subjects:	Duchenne Muscular Dystrophy metabolism mitochondria nutriceuticals dietary supplementation
Online Access:	http://www.mdpi.com/2072-6643/7/12/5498

id	doaj-6a467bf156a941688dfe0440dbe22a02
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spelling	doaj-6a467bf156a941688dfe0440dbe22a022020-11-24T20:41:59ZengMDPI AGNutrients2072-66432015-11-017129734976710.3390/nu7125498nu7125498Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular DystrophyEmma Rybalka0Cara A. Timpani1Christos G. Stathis2Alan Hayes3Matthew B. Cooke4Centre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, AustraliaCentre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, AustraliaCentre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, AustraliaCentre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, AustraliaCentre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, AustraliaDuchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. As such, supplementative nutriceuticals that target and augment the bioenergetical expansion of the metabolic pathways involved in cellular energy production have been widely investigated for their therapeutic efficacy in the treatment of DMD. We describe the metabolic nuances of dystrophin-deficient skeletal muscle and review the potential of various metabogenic and nutriceutical compounds to ameliorate the pathological and clinical progression of the disease.http://www.mdpi.com/2072-6643/7/12/5498Duchenne Muscular Dystrophymetabolismmitochondrianutriceuticalsdietary supplementation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Emma Rybalka Cara A. Timpani Christos G. Stathis Alan Hayes Matthew B. Cooke
spellingShingle	Emma Rybalka Cara A. Timpani Christos G. Stathis Alan Hayes Matthew B. Cooke Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy Nutrients Duchenne Muscular Dystrophy metabolism mitochondria nutriceuticals dietary supplementation
author_facet	Emma Rybalka Cara A. Timpani Christos G. Stathis Alan Hayes Matthew B. Cooke
author_sort	Emma Rybalka
title	Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy
title_short	Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy
title_full	Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy
title_fullStr	Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy
title_full_unstemmed	Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy
title_sort	metabogenic and nutriceutical approaches to address energy dysregulation and skeletal muscle wasting in duchenne muscular dystrophy
publisher	MDPI AG
series	Nutrients
issn	2072-6643
publishDate	2015-11-01
description	Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. As such, supplementative nutriceuticals that target and augment the bioenergetical expansion of the metabolic pathways involved in cellular energy production have been widely investigated for their therapeutic efficacy in the treatment of DMD. We describe the metabolic nuances of dystrophin-deficient skeletal muscle and review the potential of various metabogenic and nutriceutical compounds to ameliorate the pathological and clinical progression of the disease.
topic	Duchenne Muscular Dystrophy metabolism mitochondria nutriceuticals dietary supplementation
url	http://www.mdpi.com/2072-6643/7/12/5498
work_keys_str_mv	AT emmarybalka metabogenicandnutriceuticalapproachestoaddressenergydysregulationandskeletalmusclewastinginduchennemusculardystrophy AT caraatimpani metabogenicandnutriceuticalapproachestoaddressenergydysregulationandskeletalmusclewastinginduchennemusculardystrophy AT christosgstathis metabogenicandnutriceuticalapproachestoaddressenergydysregulationandskeletalmusclewastinginduchennemusculardystrophy AT alanhayes metabogenicandnutriceuticalapproachestoaddressenergydysregulationandskeletalmusclewastinginduchennemusculardystrophy AT matthewbcooke metabogenicandnutriceuticalapproachestoaddressenergydysregulationandskeletalmusclewastinginduchennemusculardystrophy
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Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy

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