Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. A...
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doaj-6a467bf156a941688dfe0440dbe22a022020-11-24T20:41:59ZengMDPI AGNutrients2072-66432015-11-017129734976710.3390/nu7125498nu7125498Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular DystrophyEmma Rybalka0Cara A. Timpani1Christos G. Stathis2Alan Hayes3Matthew B. Cooke4Centre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, AustraliaCentre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, AustraliaCentre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, AustraliaCentre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, AustraliaCentre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, AustraliaDuchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. As such, supplementative nutriceuticals that target and augment the bioenergetical expansion of the metabolic pathways involved in cellular energy production have been widely investigated for their therapeutic efficacy in the treatment of DMD. We describe the metabolic nuances of dystrophin-deficient skeletal muscle and review the potential of various metabogenic and nutriceutical compounds to ameliorate the pathological and clinical progression of the disease.http://www.mdpi.com/2072-6643/7/12/5498Duchenne Muscular Dystrophymetabolismmitochondrianutriceuticalsdietary supplementation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emma Rybalka Cara A. Timpani Christos G. Stathis Alan Hayes Matthew B. Cooke |
spellingShingle |
Emma Rybalka Cara A. Timpani Christos G. Stathis Alan Hayes Matthew B. Cooke Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy Nutrients Duchenne Muscular Dystrophy metabolism mitochondria nutriceuticals dietary supplementation |
author_facet |
Emma Rybalka Cara A. Timpani Christos G. Stathis Alan Hayes Matthew B. Cooke |
author_sort |
Emma Rybalka |
title |
Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy |
title_short |
Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy |
title_full |
Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy |
title_fullStr |
Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy |
title_full_unstemmed |
Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy |
title_sort |
metabogenic and nutriceutical approaches to address energy dysregulation and skeletal muscle wasting in duchenne muscular dystrophy |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2015-11-01 |
description |
Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. As such, supplementative nutriceuticals that target and augment the bioenergetical expansion of the metabolic pathways involved in cellular energy production have been widely investigated for their therapeutic efficacy in the treatment of DMD. We describe the metabolic nuances of dystrophin-deficient skeletal muscle and review the potential of various metabogenic and nutriceutical compounds to ameliorate the pathological and clinical progression of the disease. |
topic |
Duchenne Muscular Dystrophy metabolism mitochondria nutriceuticals dietary supplementation |
url |
http://www.mdpi.com/2072-6643/7/12/5498 |
work_keys_str_mv |
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