Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis
Abstract Objectives This systematic review evaluated the evidence for the effectiveness of Photodynamic therapy (PDT) in treating oral fungal infections, as an alternative to conventional antifungal medications. Methods Five randomized control trials (168 participants) comparing the treatment of ora...
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doaj-6a4ae1a650ac4b5e9eb82c77c63860512021-10-06T00:55:30ZengWileyClinical and Experimental Dental Research2057-43472021-06-017335436410.1002/cre2.408Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysisImaan Amina Roomaney0Haly Karen Holmes1Mark E. Engel2Faculty of Dentistry, Department of Craniofacial Biology University of the Western Cape Tygerberg South AfricaFaculty of Dentistry, Department of Oral Medicine & Periodontology University of the Western Cape Tygerberg South AfricaDepartment of Medicine University of Cape Town Cape Town South AfricaAbstract Objectives This systematic review evaluated the evidence for the effectiveness of Photodynamic therapy (PDT) in treating oral fungal infections, as an alternative to conventional antifungal medications. Methods Five randomized control trials (168 participants) comparing the treatment of oral fungal infections using met with our inclusion criteria. Clinical and microbiological improvement was assessed by random‐effects meta‐analysis. Methodological quality assessment and heterogeneity were performed using peer‐reviewed criteria. PROSPERO registration: CRD42017076. Results PDT showed statistically non‐significant increased clinical efficacy (risk ratio (RR) = 1.47 [95% confidence interval (CI), 0.68; 3.17]; three studies, n = 108 participants, I2 = 50%) and mycological efficacy (mean difference (MD) = 0.54 [95%CI, −0.71; 1.79]; three studies, n = 100; I2 = 39%) at 30 days, as compared with conventional antifungal therapy. Lack of standardization of treatment parameters and variability in the assessment of outcomes was observed across the studies. All included studies had a moderate to low risk of bias. Conclusions PDT showed comparable effectiveness at treating oral fungal infections, particularly denture stomatitis. The small number of studies in this review, small sample size and variability of methods and outcome measures across studies, highlight the need for more standardized studies with longer follow‐up periods to enable recommendation of PDT as an alternative to conventional antifungal therapy.https://doi.org/10.1002/cre2.408antifungal resistancedenture stomatitismycosesphotodynamic therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Imaan Amina Roomaney Haly Karen Holmes Mark E. Engel |
spellingShingle |
Imaan Amina Roomaney Haly Karen Holmes Mark E. Engel Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis Clinical and Experimental Dental Research antifungal resistance denture stomatitis mycoses photodynamic therapy |
author_facet |
Imaan Amina Roomaney Haly Karen Holmes Mark E. Engel |
author_sort |
Imaan Amina Roomaney |
title |
Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis |
title_short |
Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis |
title_full |
Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis |
title_fullStr |
Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis |
title_full_unstemmed |
Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis |
title_sort |
treatment of oral fungal infections using photodynamic therapy: systematic review and meta‐analysis |
publisher |
Wiley |
series |
Clinical and Experimental Dental Research |
issn |
2057-4347 |
publishDate |
2021-06-01 |
description |
Abstract Objectives This systematic review evaluated the evidence for the effectiveness of Photodynamic therapy (PDT) in treating oral fungal infections, as an alternative to conventional antifungal medications. Methods Five randomized control trials (168 participants) comparing the treatment of oral fungal infections using met with our inclusion criteria. Clinical and microbiological improvement was assessed by random‐effects meta‐analysis. Methodological quality assessment and heterogeneity were performed using peer‐reviewed criteria. PROSPERO registration: CRD42017076. Results PDT showed statistically non‐significant increased clinical efficacy (risk ratio (RR) = 1.47 [95% confidence interval (CI), 0.68; 3.17]; three studies, n = 108 participants, I2 = 50%) and mycological efficacy (mean difference (MD) = 0.54 [95%CI, −0.71; 1.79]; three studies, n = 100; I2 = 39%) at 30 days, as compared with conventional antifungal therapy. Lack of standardization of treatment parameters and variability in the assessment of outcomes was observed across the studies. All included studies had a moderate to low risk of bias. Conclusions PDT showed comparable effectiveness at treating oral fungal infections, particularly denture stomatitis. The small number of studies in this review, small sample size and variability of methods and outcome measures across studies, highlight the need for more standardized studies with longer follow‐up periods to enable recommendation of PDT as an alternative to conventional antifungal therapy. |
topic |
antifungal resistance denture stomatitis mycoses photodynamic therapy |
url |
https://doi.org/10.1002/cre2.408 |
work_keys_str_mv |
AT imaanaminaroomaney treatmentoforalfungalinfectionsusingphotodynamictherapysystematicreviewandmetaanalysis AT halykarenholmes treatmentoforalfungalinfectionsusingphotodynamictherapysystematicreviewandmetaanalysis AT markeengel treatmentoforalfungalinfectionsusingphotodynamictherapysystematicreviewandmetaanalysis |
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1716841542284476416 |