Periodontitis and cardiovascular diseases: The link and relevant mechanisms
This paper reviews the association between periodontitis and CVD. In addition, the potential mechanisms of any association between periodontitis and CVD as well as the effects of periodontal treatment on CVD are herein discussed. Among the studies carried out by this group and others on coronary art...
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doaj-6a513deeb6b04bd686d5900dd47756482020-11-24T22:39:48ZengElsevierJapanese Dental Science Review1882-76162009-09-014529810810.1016/j.jdsr.2009.06.001Periodontitis and cardiovascular diseases: The link and relevant mechanismsYuichi Izumi0Toshiyuki Nagasawa1Makoto Umeda2Hiroaki Kobayashi3Yasuo Takeuchi4Reiko Yashiro5Doosadee Hormdee6Tomonari Suda7Yuka Ushida8Nawarat Wara-aswapati9Section of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Periodontology and Endodontology, Division of Oral Maxiollofacial Rehabilitation, Health Sciences University of Hokkaido, Hokkaido, JapanSection of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, JapanSection of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, JapanSection of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, JapanSection of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Periodontology, Faculty of Dentistry, Khon Kaen University, Khon Kaen, ThailandSection of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, JapanSection of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Periodontology, Faculty of Dentistry, Khon Kaen University, Khon Kaen, ThailandThis paper reviews the association between periodontitis and CVD. In addition, the potential mechanisms of any association between periodontitis and CVD as well as the effects of periodontal treatment on CVD are herein discussed. Among the studies carried out by this group and others on coronary artery diseases, peripheral arterial diseases, abdominal aortic aneurysm, and Buerger's disease, periodontopathic bacteria were frequently detected in the diseased blood vessels, thus suggesting an association between periodontitis and CVD. The potential mechanisms of the association between periodontitis and CVD are not fully elucidated. However, inflammation and some autoimmune mechanisms, including molecular mimicry between the periodontopathic bacteria and host molecules, are suggested. The effects of periodontal treatment on CVD might thus vary among the different treatment modalities, and full-mouth mechanical debridement might induce strong transient systemic inflammatory responses in comparison to the quadrant-wise mechanical debridement.http://www.sciencedirect.com/science/article/pii/S1882761609000374PeriodontitisCardiovascular diseasesAtherosclerosisBuerger's diseasePeriodontal treatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuichi Izumi Toshiyuki Nagasawa Makoto Umeda Hiroaki Kobayashi Yasuo Takeuchi Reiko Yashiro Doosadee Hormdee Tomonari Suda Yuka Ushida Nawarat Wara-aswapati |
spellingShingle |
Yuichi Izumi Toshiyuki Nagasawa Makoto Umeda Hiroaki Kobayashi Yasuo Takeuchi Reiko Yashiro Doosadee Hormdee Tomonari Suda Yuka Ushida Nawarat Wara-aswapati Periodontitis and cardiovascular diseases: The link and relevant mechanisms Japanese Dental Science Review Periodontitis Cardiovascular diseases Atherosclerosis Buerger's disease Periodontal treatment |
author_facet |
Yuichi Izumi Toshiyuki Nagasawa Makoto Umeda Hiroaki Kobayashi Yasuo Takeuchi Reiko Yashiro Doosadee Hormdee Tomonari Suda Yuka Ushida Nawarat Wara-aswapati |
author_sort |
Yuichi Izumi |
title |
Periodontitis and cardiovascular diseases: The link and relevant mechanisms |
title_short |
Periodontitis and cardiovascular diseases: The link and relevant mechanisms |
title_full |
Periodontitis and cardiovascular diseases: The link and relevant mechanisms |
title_fullStr |
Periodontitis and cardiovascular diseases: The link and relevant mechanisms |
title_full_unstemmed |
Periodontitis and cardiovascular diseases: The link and relevant mechanisms |
title_sort |
periodontitis and cardiovascular diseases: the link and relevant mechanisms |
publisher |
Elsevier |
series |
Japanese Dental Science Review |
issn |
1882-7616 |
publishDate |
2009-09-01 |
description |
This paper reviews the association between periodontitis and CVD. In addition, the potential mechanisms of any association between periodontitis and CVD as well as the effects of periodontal treatment on CVD are herein discussed. Among the studies carried out by this group and others on coronary artery diseases, peripheral arterial diseases, abdominal aortic aneurysm, and Buerger's disease, periodontopathic bacteria were frequently detected in the diseased blood vessels, thus suggesting an association between periodontitis and CVD. The potential mechanisms of the association between periodontitis and CVD are not fully elucidated. However, inflammation and some autoimmune mechanisms, including molecular mimicry between the periodontopathic bacteria and host molecules, are suggested. The effects of periodontal treatment on CVD might thus vary among the different treatment modalities, and full-mouth mechanical debridement might induce strong transient systemic inflammatory responses in comparison to the quadrant-wise mechanical debridement. |
topic |
Periodontitis Cardiovascular diseases Atherosclerosis Buerger's disease Periodontal treatment |
url |
http://www.sciencedirect.com/science/article/pii/S1882761609000374 |
work_keys_str_mv |
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