TBE Vaccination Breakthrough Cases—Does Age Matter?
Tick-borne encephalitis (TBE) vaccines are highly effective in preventing TBE and vaccine failures (VF) are rare events. In this study, we compared the age distribution of TBE cases and TBE VF in three endemic countries: Sweden, Southern Germany, and Latvia. While the age distribution of TBE cases w...
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doaj-6a57a81f06784948867be3687fa161482021-08-26T14:26:01ZengMDPI AGVaccines2076-393X2021-08-01993293210.3390/vaccines9080932TBE Vaccination Breakthrough Cases—Does Age Matter?Heinz-J. Schmitt0Gerhard Dobler1Dace Zavadska2Zane Freimane3Dimitrios Fousteris4Wilhelm Erber5Luis Jodar6Andreas Palmborg7Medical Development, Scientific and Clinical Affairs, Pfizer Vaccines, Collegeville, PA 19426, USADepartment of Virology and Rickettsiology, German National TBE Consiliary Laboratory, Bundeswehr Institute of Microbiology, 85748 Munich, GermanyDepartment of Paediatrics, Children’s Clinical University Hospital, Riga Stradiņš University, LV-1007 Riga, LatviaDepartment of Paediatrics, Children’s Clinical University Hospital, Riga Stradiņš University, LV-1007 Riga, LatviaGlobal Medical, Scientific and Clinical Affairs, Pfizer Vaccines, 1210 Vienna, AustriaGlobal Medical, Scientific and Clinical Affairs, Pfizer Vaccines, 1210 Vienna, AustriaMedical Development, Scientific and Clinical Affairs, Pfizer Vaccines, Collegeville, PA 19426, USAMedical Development and Scientific Affairs, Pfizer Vaccines, 19138 Stockholm, SwedenTick-borne encephalitis (TBE) vaccines are highly effective in preventing TBE and vaccine failures (VF) are rare events. In this study, we compared the age distribution of TBE cases and TBE VF in three endemic countries: Sweden, Southern Germany, and Latvia. While the age distribution of TBE cases was similar for those <50 years versus those ≥50 years in all three countries, in Sweden, a higher proportion of VF cases was ≥50 years, whereas most VF cases in Latvia were <50 years of age and more evenly distributed between those <50 years versus those ≥50 in Southern Germany. Here, theoretical explanations were provided, including differences in diagnostic practices, vaccine uptake between age groups, behavioral patterns and underlying medical conditions, as to why VF were generally older in Sweden than the other countries. There is no scientific rationale to give an extra priming dose of TBE vaccine to subjects ≥50 years of age.https://www.mdpi.com/2076-393X/9/8/932tick-borne encephalitisvaccine failurevaccination failureolder adultsSweden |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heinz-J. Schmitt Gerhard Dobler Dace Zavadska Zane Freimane Dimitrios Fousteris Wilhelm Erber Luis Jodar Andreas Palmborg |
spellingShingle |
Heinz-J. Schmitt Gerhard Dobler Dace Zavadska Zane Freimane Dimitrios Fousteris Wilhelm Erber Luis Jodar Andreas Palmborg TBE Vaccination Breakthrough Cases—Does Age Matter? Vaccines tick-borne encephalitis vaccine failure vaccination failure older adults Sweden |
author_facet |
Heinz-J. Schmitt Gerhard Dobler Dace Zavadska Zane Freimane Dimitrios Fousteris Wilhelm Erber Luis Jodar Andreas Palmborg |
author_sort |
Heinz-J. Schmitt |
title |
TBE Vaccination Breakthrough Cases—Does Age Matter? |
title_short |
TBE Vaccination Breakthrough Cases—Does Age Matter? |
title_full |
TBE Vaccination Breakthrough Cases—Does Age Matter? |
title_fullStr |
TBE Vaccination Breakthrough Cases—Does Age Matter? |
title_full_unstemmed |
TBE Vaccination Breakthrough Cases—Does Age Matter? |
title_sort |
tbe vaccination breakthrough cases—does age matter? |
publisher |
MDPI AG |
series |
Vaccines |
issn |
2076-393X |
publishDate |
2021-08-01 |
description |
Tick-borne encephalitis (TBE) vaccines are highly effective in preventing TBE and vaccine failures (VF) are rare events. In this study, we compared the age distribution of TBE cases and TBE VF in three endemic countries: Sweden, Southern Germany, and Latvia. While the age distribution of TBE cases was similar for those <50 years versus those ≥50 years in all three countries, in Sweden, a higher proportion of VF cases was ≥50 years, whereas most VF cases in Latvia were <50 years of age and more evenly distributed between those <50 years versus those ≥50 in Southern Germany. Here, theoretical explanations were provided, including differences in diagnostic practices, vaccine uptake between age groups, behavioral patterns and underlying medical conditions, as to why VF were generally older in Sweden than the other countries. There is no scientific rationale to give an extra priming dose of TBE vaccine to subjects ≥50 years of age. |
topic |
tick-borne encephalitis vaccine failure vaccination failure older adults Sweden |
url |
https://www.mdpi.com/2076-393X/9/8/932 |
work_keys_str_mv |
AT heinzjschmitt tbevaccinationbreakthroughcasesdoesagematter AT gerharddobler tbevaccinationbreakthroughcasesdoesagematter AT dacezavadska tbevaccinationbreakthroughcasesdoesagematter AT zanefreimane tbevaccinationbreakthroughcasesdoesagematter AT dimitriosfousteris tbevaccinationbreakthroughcasesdoesagematter AT wilhelmerber tbevaccinationbreakthroughcasesdoesagematter AT luisjodar tbevaccinationbreakthroughcasesdoesagematter AT andreaspalmborg tbevaccinationbreakthroughcasesdoesagematter |
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1721189485010485248 |