Effect of Cinnamaldehyde, an Anti-Inflammatory Agent, on the Surface Characteristics of a Plaster of Paris – CaCO3 Hydrogel for Bone Substitution in Biomedicine
Combining an anti-inflammatory agent derived from a plant essential oil, such as cinnamaldehyde, with bioabsorbable and osteoconductive material as a bone substitute is a challenge in biomedical technology. In this study, cinnamaldehyde, a good anti-inflammatory agent with an aromatic ?,...
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doaj-6a57d74d802d4177a2509f7b4fe2e5132020-12-02T18:33:14ZengUniversitas IndonesiaInternational Journal of Technology2086-96142087-21002020-11-0111596397310.14716/ijtech.v11i5.43134313Effect of Cinnamaldehyde, an Anti-Inflammatory Agent, on the Surface Characteristics of a Plaster of Paris – CaCO3 Hydrogel for Bone Substitution in BiomedicineAnne Handrini Dewi0Dedy Kusuma Yulianto1Ika Dewi Ana2Rochmadi Rochmadi3Widowati Siswomihardjo4Department of Dental Biomedical Sciences, Faculty of Dentistry, Universitas Gadjah MadaDepartment of Dental Biomedical Sciences, Faculty of Dentistry, Universitas Gadjah MadaDepartment of Dental Biomedical Sciences, Faculty of Dentistry, Universitas Gadjah MadaDepartment of Chemical Engineering, Faculty of Engineering, Universitas Gadjah MadaDepartment of Dental Biomaterials, Faculty of Dentistry, Universitas Gadjah MadaCombining an anti-inflammatory agent derived from a plant essential oil, such as cinnamaldehyde, with bioabsorbable and osteoconductive material as a bone substitute is a challenge in biomedical technology. In this study, cinnamaldehyde, a good anti-inflammatory agent with an aromatic ?, ?-unsaturated aldehyde derived from cinnamon, was loaded in composites of plaster of Paris (POP) and calcium carbonate (CaCO3) hydrogel as a bone substitute. However, during blood–biomaterial interactions, which start after surgical implantation, blood protein adsorption to the biomaterial surface occurs prior to interaction with host cells. Therefore, before a device is ready for implantation, the influence of cinnamaldehyde on the property of the composite, especially its surface characteristics, needs to be examined. The aim of this research was to investigate the effect of cinnamaldehyde on the surface topography, contact angle, and surface roughness of a POP–CaCO3 hydrogel scaffold. The results indicate that cinnamaldehyde increased the contact angle and surface roughness of the POP hydrogel, which seemed to be homogenous on all surfaces.https://ijtech.eng.ui.ac.id/article/view/4313bone substitutecaco3 hydrogelcinnamaldehydepopsurface characteristics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anne Handrini Dewi Dedy Kusuma Yulianto Ika Dewi Ana Rochmadi Rochmadi Widowati Siswomihardjo |
spellingShingle |
Anne Handrini Dewi Dedy Kusuma Yulianto Ika Dewi Ana Rochmadi Rochmadi Widowati Siswomihardjo Effect of Cinnamaldehyde, an Anti-Inflammatory Agent, on the Surface Characteristics of a Plaster of Paris – CaCO3 Hydrogel for Bone Substitution in Biomedicine International Journal of Technology bone substitute caco3 hydrogel cinnamaldehyde pop surface characteristics |
author_facet |
Anne Handrini Dewi Dedy Kusuma Yulianto Ika Dewi Ana Rochmadi Rochmadi Widowati Siswomihardjo |
author_sort |
Anne Handrini Dewi |
title |
Effect of Cinnamaldehyde, an Anti-Inflammatory Agent, on the Surface Characteristics of a Plaster of Paris – CaCO3 Hydrogel for Bone Substitution in Biomedicine |
title_short |
Effect of Cinnamaldehyde, an Anti-Inflammatory Agent, on the Surface Characteristics of a Plaster of Paris – CaCO3 Hydrogel for Bone Substitution in Biomedicine |
title_full |
Effect of Cinnamaldehyde, an Anti-Inflammatory Agent, on the Surface Characteristics of a Plaster of Paris – CaCO3 Hydrogel for Bone Substitution in Biomedicine |
title_fullStr |
Effect of Cinnamaldehyde, an Anti-Inflammatory Agent, on the Surface Characteristics of a Plaster of Paris – CaCO3 Hydrogel for Bone Substitution in Biomedicine |
title_full_unstemmed |
Effect of Cinnamaldehyde, an Anti-Inflammatory Agent, on the Surface Characteristics of a Plaster of Paris – CaCO3 Hydrogel for Bone Substitution in Biomedicine |
title_sort |
effect of cinnamaldehyde, an anti-inflammatory agent, on the surface characteristics of a plaster of paris – caco3 hydrogel for bone substitution in biomedicine |
publisher |
Universitas Indonesia |
series |
International Journal of Technology |
issn |
2086-9614 2087-2100 |
publishDate |
2020-11-01 |
description |
Combining an anti-inflammatory agent derived from a plant essential oil,
such as cinnamaldehyde, with bioabsorbable and osteoconductive material as a
bone substitute is a challenge in biomedical technology. In this study,
cinnamaldehyde, a good anti-inflammatory agent with an aromatic ?, ?-unsaturated aldehyde derived from cinnamon, was loaded in composites of
plaster of Paris (POP) and calcium carbonate (CaCO3) hydrogel as a
bone substitute. However, during blood–biomaterial interactions, which start
after surgical implantation, blood protein adsorption to the biomaterial
surface occurs prior to interaction with host cells. Therefore, before a device
is ready for implantation, the influence of cinnamaldehyde on the property of
the composite, especially its surface characteristics, needs to be examined.
The aim of this research was to investigate the effect of cinnamaldehyde on the
surface topography, contact angle, and surface roughness of a POP–CaCO3 hydrogel
scaffold. The results indicate that cinnamaldehyde increased the contact angle
and surface roughness of the POP hydrogel, which seemed to be homogenous on all
surfaces. |
topic |
bone substitute caco3 hydrogel cinnamaldehyde pop surface characteristics |
url |
https://ijtech.eng.ui.ac.id/article/view/4313 |
work_keys_str_mv |
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