Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence
We systematically searched regional and international databases and screened 1658 non-duplicate records describing women with suspected or confirmed ZIKV infection, intending to breastfeed or give breast milk to an infant to examine the potential of mother-to-child transmission of Zika virus (ZIKV)...
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doaj-6a5aef6f1b7a4f5f9e674afdcd64caae2021-01-19T00:00:36ZengMDPI AGViruses1999-49152021-01-011312312310.3390/v13010123Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the EvidenceElizabeth Centeno-Tablante0Melisa Medina-Rivera1Julia L. Finkelstein2Heather S. Herman3Pura Rayco-Solon4Maria Nieves Garcia-Casal5Lisa Rogers6Kate Ghezzi-Kopel7Mildred P. Zambrano Leal8Joyce K. Andrade Velasquez9Juan G. Chang Asinc10Juan Pablo Peña-Rosas11Saurabh Mehta12Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USADivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USADivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USADivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USADepartment of Maternal, Newborn, Child and Adolescent Health and Ageing, World Health Organization, Geneva CH-1211, SwitzerlandDepartment of Nutrition and Food Safety, World Health Organization, Geneva, CH-1211, SwitzerlandDepartment of Nutrition and Food Safety, World Health Organization, Geneva, CH-1211, SwitzerlandAlbert R. Mann Library, Cornell University, Ithaca, NY 14853, USAHospital de Niños Roberto Gilbert Elizalde, Guayaquil 090514, EcuadorHospital de Niños Roberto Gilbert Elizalde, Guayaquil 090514, EcuadorHospital de Niños Roberto Gilbert Elizalde, Guayaquil 090514, EcuadorDepartment of Nutrition and Food Safety, World Health Organization, Geneva, CH-1211, SwitzerlandDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USAWe systematically searched regional and international databases and screened 1658 non-duplicate records describing women with suspected or confirmed ZIKV infection, intending to breastfeed or give breast milk to an infant to examine the potential of mother-to-child transmission of Zika virus (ZIKV) through breast milk or breastfeeding-related practices. Fourteen studies met our inclusion criteria and inform this analysis. These studies reported on 97 mother–children pairs who provided breast milk for ZIKV assessment. Seventeen breast milk samples from different women were found positive for ZIKV via RT-PCR, and ZIKV replication was found in cell cultures from five out of seven breast milk samples from different women. Only three out of six infants who had ZIKV infection were breastfed, no evidence of clinical complications was found to be associated with ZIKV RNA in breast milk. This review updates our previous report by including 12 new articles, in which we found no evidence of ZIKV mother-to-child transmission through breast milk intake or breastfeeding. As the certainty of the present evidence is low, additional studies are still warranted to determine if ZIKV can be transmitted through breastfeeding.https://www.mdpi.com/1999-4915/13/1/123Zika virusZika virus infectionperinatal transmissionmother-to-child transmissionbreast milkbreastfeeding |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elizabeth Centeno-Tablante Melisa Medina-Rivera Julia L. Finkelstein Heather S. Herman Pura Rayco-Solon Maria Nieves Garcia-Casal Lisa Rogers Kate Ghezzi-Kopel Mildred P. Zambrano Leal Joyce K. Andrade Velasquez Juan G. Chang Asinc Juan Pablo Peña-Rosas Saurabh Mehta |
spellingShingle |
Elizabeth Centeno-Tablante Melisa Medina-Rivera Julia L. Finkelstein Heather S. Herman Pura Rayco-Solon Maria Nieves Garcia-Casal Lisa Rogers Kate Ghezzi-Kopel Mildred P. Zambrano Leal Joyce K. Andrade Velasquez Juan G. Chang Asinc Juan Pablo Peña-Rosas Saurabh Mehta Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence Viruses Zika virus Zika virus infection perinatal transmission mother-to-child transmission breast milk breastfeeding |
author_facet |
Elizabeth Centeno-Tablante Melisa Medina-Rivera Julia L. Finkelstein Heather S. Herman Pura Rayco-Solon Maria Nieves Garcia-Casal Lisa Rogers Kate Ghezzi-Kopel Mildred P. Zambrano Leal Joyce K. Andrade Velasquez Juan G. Chang Asinc Juan Pablo Peña-Rosas Saurabh Mehta |
author_sort |
Elizabeth Centeno-Tablante |
title |
Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence |
title_short |
Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence |
title_full |
Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence |
title_fullStr |
Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence |
title_full_unstemmed |
Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence |
title_sort |
update on the transmission of zika virus through breast milk and breastfeeding: a systematic review of the evidence |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2021-01-01 |
description |
We systematically searched regional and international databases and screened 1658 non-duplicate records describing women with suspected or confirmed ZIKV infection, intending to breastfeed or give breast milk to an infant to examine the potential of mother-to-child transmission of Zika virus (ZIKV) through breast milk or breastfeeding-related practices. Fourteen studies met our inclusion criteria and inform this analysis. These studies reported on 97 mother–children pairs who provided breast milk for ZIKV assessment. Seventeen breast milk samples from different women were found positive for ZIKV via RT-PCR, and ZIKV replication was found in cell cultures from five out of seven breast milk samples from different women. Only three out of six infants who had ZIKV infection were breastfed, no evidence of clinical complications was found to be associated with ZIKV RNA in breast milk. This review updates our previous report by including 12 new articles, in which we found no evidence of ZIKV mother-to-child transmission through breast milk intake or breastfeeding. As the certainty of the present evidence is low, additional studies are still warranted to determine if ZIKV can be transmitted through breastfeeding. |
topic |
Zika virus Zika virus infection perinatal transmission mother-to-child transmission breast milk breastfeeding |
url |
https://www.mdpi.com/1999-4915/13/1/123 |
work_keys_str_mv |
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