Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
A randomized, parallel controlled, open-label clinical trial was conducted to evaluate the effect of a botanic compound berberine (BBR) on NAFLD.A randomized, parallel controlled, open-label clinical trial was conducted in three medical centers (NIH Registration number: NCT00633282). A total of 184...
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doaj-6a5c186db6c341ce9910918d0b2c03372020-11-25T01:42:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01108e013417210.1371/journal.pone.0134172Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.Hong-Mei YanMing-Feng XiaYan WangXin-Xia ChangXiu-Zhong YaoSheng-Xiang RaoMeng-Su ZengYin-Fang TuRu FengWei-Ping JiaJun LiuWei DengJian-Dong JiangXin GaoA randomized, parallel controlled, open-label clinical trial was conducted to evaluate the effect of a botanic compound berberine (BBR) on NAFLD.A randomized, parallel controlled, open-label clinical trial was conducted in three medical centers (NIH Registration number: NCT00633282). A total of 184 eligible patients with NAFLD were enrolled and randomly received (i) lifestyle intervention (LSI), (ii) LSI plus pioglitazone (PGZ) 15mg qd, and (iii) LSI plus BBR 0.5g tid, respectively, for 16 weeks. Hepatic fat content (HFC), serum glucose and lipid profiles, liver enzymes and serum and urine BBR concentrations were assessed before and after treatment. We also analyzed hepatic BBR content and expression of genes related to glucose and lipid metabolism in an animal model of NAFLD treated with BBR.As compared with LSI, BBR treatment plus LSI resulted in a significant reduction of HFC (52.7% vs 36.4%, p = 0.008), paralleled with better improvement in body weight, HOMA-IR, and serum lipid profiles (all p<0.05). BBR was more effective than PGZ 15mg qd in reducing body weight and improving lipid profile. BBR-related adverse events were mild and mainly occurred in digestive system. Serum and urine BBR concentrations were 6.99ng/ml and 79.2ng/ml, respectively, in the BBR-treated subjects. Animal experiments showed that BBR located favorably in the liver and altered hepatic metabolism-related gene expression.BBR ameliorates NAFLD and related metabolic disorders. The therapeutic effect of BBR on NAFLD may involve a direct regulation of hepatic lipid metabolism.ClinicalTrials.gov NCT00633282.http://europepmc.org/articles/PMC4529214?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong-Mei Yan Ming-Feng Xia Yan Wang Xin-Xia Chang Xiu-Zhong Yao Sheng-Xiang Rao Meng-Su Zeng Yin-Fang Tu Ru Feng Wei-Ping Jia Jun Liu Wei Deng Jian-Dong Jiang Xin Gao |
spellingShingle |
Hong-Mei Yan Ming-Feng Xia Yan Wang Xin-Xia Chang Xiu-Zhong Yao Sheng-Xiang Rao Meng-Su Zeng Yin-Fang Tu Ru Feng Wei-Ping Jia Jun Liu Wei Deng Jian-Dong Jiang Xin Gao Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. PLoS ONE |
author_facet |
Hong-Mei Yan Ming-Feng Xia Yan Wang Xin-Xia Chang Xiu-Zhong Yao Sheng-Xiang Rao Meng-Su Zeng Yin-Fang Tu Ru Feng Wei-Ping Jia Jun Liu Wei Deng Jian-Dong Jiang Xin Gao |
author_sort |
Hong-Mei Yan |
title |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. |
title_short |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. |
title_full |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. |
title_fullStr |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. |
title_full_unstemmed |
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. |
title_sort |
efficacy of berberine in patients with non-alcoholic fatty liver disease. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
A randomized, parallel controlled, open-label clinical trial was conducted to evaluate the effect of a botanic compound berberine (BBR) on NAFLD.A randomized, parallel controlled, open-label clinical trial was conducted in three medical centers (NIH Registration number: NCT00633282). A total of 184 eligible patients with NAFLD were enrolled and randomly received (i) lifestyle intervention (LSI), (ii) LSI plus pioglitazone (PGZ) 15mg qd, and (iii) LSI plus BBR 0.5g tid, respectively, for 16 weeks. Hepatic fat content (HFC), serum glucose and lipid profiles, liver enzymes and serum and urine BBR concentrations were assessed before and after treatment. We also analyzed hepatic BBR content and expression of genes related to glucose and lipid metabolism in an animal model of NAFLD treated with BBR.As compared with LSI, BBR treatment plus LSI resulted in a significant reduction of HFC (52.7% vs 36.4%, p = 0.008), paralleled with better improvement in body weight, HOMA-IR, and serum lipid profiles (all p<0.05). BBR was more effective than PGZ 15mg qd in reducing body weight and improving lipid profile. BBR-related adverse events were mild and mainly occurred in digestive system. Serum and urine BBR concentrations were 6.99ng/ml and 79.2ng/ml, respectively, in the BBR-treated subjects. Animal experiments showed that BBR located favorably in the liver and altered hepatic metabolism-related gene expression.BBR ameliorates NAFLD and related metabolic disorders. The therapeutic effect of BBR on NAFLD may involve a direct regulation of hepatic lipid metabolism.ClinicalTrials.gov NCT00633282. |
url |
http://europepmc.org/articles/PMC4529214?pdf=render |
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