Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure
Approximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a contributing cause. Current HF drugs (e.g., β-blockers, ACEi) target intracellular signaling cascades downstream of cell surface receptors to p...
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doaj-6a62357b07e04e5fb5b3a12324b0baca2020-11-25T01:03:13ZengMDPI AGNutrients2072-66432018-08-01108112010.3390/nu10081120nu10081120Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart FailureLevi W. Evans0Bradley S. Ferguson1Department of Agriculture, Nutrition, & Veterinary Sciences, University of Nevada, Reno, NV 89557, USADepartment of Agriculture, Nutrition, & Veterinary Sciences, University of Nevada, Reno, NV 89557, USAApproximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a contributing cause. Current HF drugs (e.g., β-blockers, ACEi) target intracellular signaling cascades downstream of cell surface receptors to prevent cardiac pump dysfunction. However, these drugs fail to target other redundant intracellular signaling pathways and, therefore, limit drug efficacy. As such, it has been postulated that compounds designed to target shared downstream mediators of these signaling pathways would be more efficacious for the treatment of HF. Histone deacetylation has been linked as a key pathogenetic element for the development of HF. Lysine residues undergo diverse and reversible post-translational modifications that include acetylation and have historically been studied as epigenetic modifiers of histone tails within chromatin that provide an important mechanism for regulating gene expression. Of recent, bioactive compounds within our diet have been linked to the regulation of gene expression, in part, through regulation of the epi-genome. It has been reported that food bioactives regulate histone acetylation via direct regulation of writer (histone acetyl transferases, HATs) and eraser (histone deacetylases, HDACs) proteins. Therefore, bioactive food compounds offer unique therapeutic strategies as epigenetic modifiers of heart failure. This review will highlight food bio-actives as modifiers of histone deacetylase activity in the heart.http://www.mdpi.com/2072-6643/10/8/1120heart failurehistone deacetylaseHDACHDAC inhibitorsfood bio-activesphytochemicals |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Levi W. Evans Bradley S. Ferguson |
spellingShingle |
Levi W. Evans Bradley S. Ferguson Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure Nutrients heart failure histone deacetylase HDAC HDAC inhibitors food bio-actives phytochemicals |
author_facet |
Levi W. Evans Bradley S. Ferguson |
author_sort |
Levi W. Evans |
title |
Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure |
title_short |
Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure |
title_full |
Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure |
title_fullStr |
Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure |
title_full_unstemmed |
Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure |
title_sort |
food bioactive hdac inhibitors in the epigenetic regulation of heart failure |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-08-01 |
description |
Approximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a contributing cause. Current HF drugs (e.g., β-blockers, ACEi) target intracellular signaling cascades downstream of cell surface receptors to prevent cardiac pump dysfunction. However, these drugs fail to target other redundant intracellular signaling pathways and, therefore, limit drug efficacy. As such, it has been postulated that compounds designed to target shared downstream mediators of these signaling pathways would be more efficacious for the treatment of HF. Histone deacetylation has been linked as a key pathogenetic element for the development of HF. Lysine residues undergo diverse and reversible post-translational modifications that include acetylation and have historically been studied as epigenetic modifiers of histone tails within chromatin that provide an important mechanism for regulating gene expression. Of recent, bioactive compounds within our diet have been linked to the regulation of gene expression, in part, through regulation of the epi-genome. It has been reported that food bioactives regulate histone acetylation via direct regulation of writer (histone acetyl transferases, HATs) and eraser (histone deacetylases, HDACs) proteins. Therefore, bioactive food compounds offer unique therapeutic strategies as epigenetic modifiers of heart failure. This review will highlight food bio-actives as modifiers of histone deacetylase activity in the heart. |
topic |
heart failure histone deacetylase HDAC HDAC inhibitors food bio-actives phytochemicals |
url |
http://www.mdpi.com/2072-6643/10/8/1120 |
work_keys_str_mv |
AT leviwevans foodbioactivehdacinhibitorsintheepigeneticregulationofheartfailure AT bradleysferguson foodbioactivehdacinhibitorsintheepigeneticregulationofheartfailure |
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1725201712249044992 |