Evaluation of the Possible Antioxidative Role of Bilirubin Protecting from Free Radical Related Illnesses in Neonates
There are disparate data regarding whether bilirubin is protective or toxic during free radical related illness among neonates. Seventy one infants with gestational age (GA) of <32 weeks and/or birth weight (BW) of <1500 g, who survived beyond 4 weeks and completed physical examinations were e...
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Tehran University of Medical Sciences
2012-03-01
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doaj-6a661156de5140a485064ecf19de848a2020-11-25T03:58:35ZengTehran University of Medical SciencesActa Medica Iranica0044-60250173-59692012-03-01503153163Evaluation of the Possible Antioxidative Role of Bilirubin Protecting from Free Radical Related Illnesses in NeonatesParisa MohagheghiArash Poorsattar Bejeh MirKarim Poorsattar Bejeh MirSeyed Mohammad FereshtehnejadThere are disparate data regarding whether bilirubin is protective or toxic during free radical related illness among neonates. Seventy one infants with gestational age (GA) of <32 weeks and/or birth weight (BW) of <1500 g, who survived beyond 4 weeks and completed physical examinations were enrolled in this study. The infants were divided into two groups based on the presence or absence of advanced retinopathy of prematurity (ROP), grade III intraventricular hemorrhage (IVH), grade III necrotizing enterocolitis (NEC), respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), sepsis or severe fungal infection (SFI). The mean of total serum bilirubin (TSB) of the first 14 days of life were measured and compared between these two groups. A significant lower TSB were found in severe form of ROP (P<0.001), grade III NEC (P=0.008), grade III IVH (P=0.021), SFI (P=0.003) and sepsis (P=0.007) in comparison to mild or disease free status. Moreover, the cut-off point of 5.1 mg/dl for the mean of TSB had the sensitivity of 88.1% and specificity of 84.6% to detect severe grades of ROP. Also the cut-off point of 3.25 mg/dl had 97.2% sensitivity and 100% specificity in order to distinguish SFI. It is concluded that bilirubin may play an antioxidant role in vivo as in vitro; and protect preterm infant against these free radical related disorders. Our findings suggest that not only the upper limits of serum bilirubin, but also the lower limits must be taking into account in order to both preventing from neurotoxic effects and free radical based illnesses, respectively.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/20359.pdf&manuscript_id=20359BilirubinFree RadicalPretermAntioxidantRetinopathy of prematurity (ROP) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Parisa Mohagheghi Arash Poorsattar Bejeh Mir Karim Poorsattar Bejeh Mir Seyed Mohammad Fereshtehnejad |
spellingShingle |
Parisa Mohagheghi Arash Poorsattar Bejeh Mir Karim Poorsattar Bejeh Mir Seyed Mohammad Fereshtehnejad Evaluation of the Possible Antioxidative Role of Bilirubin Protecting from Free Radical Related Illnesses in Neonates Acta Medica Iranica Bilirubin Free Radical Preterm Antioxidant Retinopathy of prematurity (ROP) |
author_facet |
Parisa Mohagheghi Arash Poorsattar Bejeh Mir Karim Poorsattar Bejeh Mir Seyed Mohammad Fereshtehnejad |
author_sort |
Parisa Mohagheghi |
title |
Evaluation of the Possible Antioxidative Role of Bilirubin Protecting from Free Radical Related Illnesses in Neonates |
title_short |
Evaluation of the Possible Antioxidative Role of Bilirubin Protecting from Free Radical Related Illnesses in Neonates |
title_full |
Evaluation of the Possible Antioxidative Role of Bilirubin Protecting from Free Radical Related Illnesses in Neonates |
title_fullStr |
Evaluation of the Possible Antioxidative Role of Bilirubin Protecting from Free Radical Related Illnesses in Neonates |
title_full_unstemmed |
Evaluation of the Possible Antioxidative Role of Bilirubin Protecting from Free Radical Related Illnesses in Neonates |
title_sort |
evaluation of the possible antioxidative role of bilirubin protecting from free radical related illnesses in neonates |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 0173-5969 |
publishDate |
2012-03-01 |
description |
There are disparate data regarding whether bilirubin is protective or toxic during free radical related illness among neonates. Seventy one infants with gestational age (GA) of <32 weeks and/or birth weight (BW) of <1500 g, who survived beyond 4 weeks and completed physical examinations were enrolled in this study. The infants were divided into two groups based on the presence or absence of advanced retinopathy of prematurity (ROP), grade III intraventricular hemorrhage (IVH), grade III necrotizing enterocolitis (NEC), respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), sepsis or severe fungal infection (SFI). The mean of total serum bilirubin (TSB) of the first 14 days of life were measured and compared between these two groups. A significant lower TSB were found in severe form of ROP (P<0.001), grade III NEC (P=0.008), grade III IVH (P=0.021), SFI (P=0.003) and sepsis (P=0.007) in comparison to mild or disease free status. Moreover, the cut-off point of 5.1 mg/dl for the mean of TSB had the sensitivity of 88.1% and specificity of 84.6% to detect severe grades of ROP. Also the cut-off point of 3.25 mg/dl had 97.2% sensitivity and 100% specificity in order to distinguish SFI. It is concluded that bilirubin may play an antioxidant role in vivo as in vitro; and protect preterm infant against these free radical related disorders. Our findings suggest that not only the upper limits of serum bilirubin, but also the lower limits must be taking into account in order to both preventing from neurotoxic effects and free radical based illnesses, respectively. |
topic |
Bilirubin Free Radical Preterm Antioxidant Retinopathy of prematurity (ROP) |
url |
http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/20359.pdf&manuscript_id=20359 |
work_keys_str_mv |
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