Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo
Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress...
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doaj-6a6c8be2b21c446abe3007aa9fb0de0f2020-11-25T01:08:00ZengMDPI AGNutrients2072-66432015-04-01742850286510.3390/nu7042850nu7042850Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In VivoAn-Sheng Cheng0Yu-Hsiang Cheng1Chi-Ying Lee2Chin-Yuan Chung3Wen-Chang Chang4Department of Medicinal Plant Development, Yupintang Traditional Chinese Medicine Foundation, 2F., No. 398, Zengzi Rd., Zuoying District, Kaohsiung City 813, TaiwanDepartment of Science, University of Auckland, 23 Symonds Street, Auckland 1142, New ZealandDepartment of Medicinal Plant Development, Yupintang Traditional Chinese Medicine Foundation, 2F., No. 398, Zengzi Rd., Zuoying District, Kaohsiung City 813, TaiwanDepartment of Medicinal Plant Development, Yupintang Traditional Chinese Medicine Foundation, 2F., No. 398, Zengzi Rd., Zuoying District, Kaohsiung City 813, TaiwanDepartment of Medicinal Plant Development, Yupintang Traditional Chinese Medicine Foundation, 2F., No. 398, Zengzi Rd., Zuoying District, Kaohsiung City 813, TaiwanMethylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction.http://www.mdpi.com/2072-6643/7/4/2850resveratrolmethylglyoxalnuclear factor erythroid 2-related factor 2retinoic aciddiabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
An-Sheng Cheng Yu-Hsiang Cheng Chi-Ying Lee Chin-Yuan Chung Wen-Chang Chang |
spellingShingle |
An-Sheng Cheng Yu-Hsiang Cheng Chi-Ying Lee Chin-Yuan Chung Wen-Chang Chang Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo Nutrients resveratrol methylglyoxal nuclear factor erythroid 2-related factor 2 retinoic acid diabetes |
author_facet |
An-Sheng Cheng Yu-Hsiang Cheng Chi-Ying Lee Chin-Yuan Chung Wen-Chang Chang |
author_sort |
An-Sheng Cheng |
title |
Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo |
title_short |
Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo |
title_full |
Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo |
title_fullStr |
Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo |
title_full_unstemmed |
Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo |
title_sort |
resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2015-04-01 |
description |
Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction. |
topic |
resveratrol methylglyoxal nuclear factor erythroid 2-related factor 2 retinoic acid diabetes |
url |
http://www.mdpi.com/2072-6643/7/4/2850 |
work_keys_str_mv |
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