The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM structures that provide insight into MiDAC’s mode of ass...
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Nature Publishing Group
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17078-8 |
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doaj-6a71d260306a424c936ce21edc1334822021-06-27T11:13:51ZengNature Publishing GroupNature Communications2041-17232020-06-0111111510.1038/s41467-020-17078-8The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structureRobert E. Turnbull0Louise Fairall1Almutasem Saleh2Emma Kelsall3Kyle L. Morris4T. J. Ragan5Christos G. Savva6Aditya Chandru7Christopher J. Millard8Olga V. Makarova9Corinne J. Smith10Alan M. Roseman11Andrew M. Fry12Shaun M. Cowley13John W. R. Schwabe14Leicester Institute of Structural and Chemical Biology, University of LeicesterLeicester Institute of Structural and Chemical Biology, University of LeicesterLeicester Institute of Structural and Chemical Biology, University of LeicesterDepartment of Molecular and Cell Biology, University of LeicesterSchool of Life Sciences, University of WarwickLeicester Institute of Structural and Chemical Biology, University of LeicesterLeicester Institute of Structural and Chemical Biology, University of LeicesterDepartment of Molecular and Cell Biology, University of LeicesterLeicester Institute of Structural and Chemical Biology, University of LeicesterDepartment of Molecular and Cell Biology, University of LeicesterSchool of Life Sciences, University of WarwickDivision of Molecular and Cellular Function, University of ManchesterDepartment of Molecular and Cell Biology, University of LeicesterDepartment of Molecular and Cell Biology, University of LeicesterLeicester Institute of Structural and Chemical Biology, University of LeicesterThe MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM structures that provide insight into MiDAC’s mode of assembly.https://doi.org/10.1038/s41467-020-17078-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Robert E. Turnbull Louise Fairall Almutasem Saleh Emma Kelsall Kyle L. Morris T. J. Ragan Christos G. Savva Aditya Chandru Christopher J. Millard Olga V. Makarova Corinne J. Smith Alan M. Roseman Andrew M. Fry Shaun M. Cowley John W. R. Schwabe |
| spellingShingle |
Robert E. Turnbull Louise Fairall Almutasem Saleh Emma Kelsall Kyle L. Morris T. J. Ragan Christos G. Savva Aditya Chandru Christopher J. Millard Olga V. Makarova Corinne J. Smith Alan M. Roseman Andrew M. Fry Shaun M. Cowley John W. R. Schwabe The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure Nature Communications |
| author_facet |
Robert E. Turnbull Louise Fairall Almutasem Saleh Emma Kelsall Kyle L. Morris T. J. Ragan Christos G. Savva Aditya Chandru Christopher J. Millard Olga V. Makarova Corinne J. Smith Alan M. Roseman Andrew M. Fry Shaun M. Cowley John W. R. Schwabe |
| author_sort |
Robert E. Turnbull |
| title |
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure |
| title_short |
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure |
| title_full |
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure |
| title_fullStr |
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure |
| title_full_unstemmed |
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure |
| title_sort |
midac histone deacetylase complex is essential for embryonic development and has a unique multivalent structure |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-06-01 |
| description |
The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM structures that provide insight into MiDAC’s mode of assembly. |
| url |
https://doi.org/10.1038/s41467-020-17078-8 |
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