Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Cancer cells adapt their metabolism to survive limited nutrient availability. Here, the authors show that in conditions of limited glucose or glutamine availability, pancreatic ductal adenocarcinoma cells can use collagen-derived proline to foster the TCA cycle and allow cell survival bothin vitro a...

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Main Authors:	Orianne Olivares, Jared R. Mayers, Victoire Gouirand, Margaret E. Torrence, Tristan Gicquel, Laurence Borge, Sophie Lac, Julie Roques, Marie-Noëlle Lavaut, Patrice Berthezène, Marion Rubis, Veronique Secq, Stéphane Garcia, Vincent Moutardier, Dominique Lombardo, Juan Lucio Iovanna, Richard Tomasini, Fabienne Guillaumond, Matthew G. Vander Heiden, Sophie Vasseur
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms16031

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spelling	doaj-6a73d2e74efe45e79489251d11428d7b2021-05-11T07:52:45ZengNature Publishing GroupNature Communications2041-17232017-07-018111410.1038/ncomms16031Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditionsOrianne Olivares0Jared R. Mayers1Victoire Gouirand2Margaret E. Torrence3Tristan Gicquel4Laurence Borge5Sophie Lac6Julie Roques7Marie-Noëlle Lavaut8Patrice Berthezène9Marion Rubis10Veronique Secq11Stéphane Garcia12Vincent Moutardier13Dominique Lombardo14Juan Lucio Iovanna15Richard Tomasini16Fabienne Guillaumond17Matthew G. Vander Heiden18Sophie Vasseur19Centre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of TechnologyCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of TechnologyCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleAix Marseille Univ, INSERM, CRO2Centre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of TechnologyCentre de Recherche en Cancérologie de Marseille (CRCM), Unité 1068, Institut National de la Santé et de la Recherche MédicaleCancer cells adapt their metabolism to survive limited nutrient availability. Here, the authors show that in conditions of limited glucose or glutamine availability, pancreatic ductal adenocarcinoma cells can use collagen-derived proline to foster the TCA cycle and allow cell survival bothin vitro and in vivo.https://doi.org/10.1038/ncomms16031
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Orianne Olivares Jared R. Mayers Victoire Gouirand Margaret E. Torrence Tristan Gicquel Laurence Borge Sophie Lac Julie Roques Marie-Noëlle Lavaut Patrice Berthezène Marion Rubis Veronique Secq Stéphane Garcia Vincent Moutardier Dominique Lombardo Juan Lucio Iovanna Richard Tomasini Fabienne Guillaumond Matthew G. Vander Heiden Sophie Vasseur
spellingShingle	Orianne Olivares Jared R. Mayers Victoire Gouirand Margaret E. Torrence Tristan Gicquel Laurence Borge Sophie Lac Julie Roques Marie-Noëlle Lavaut Patrice Berthezène Marion Rubis Veronique Secq Stéphane Garcia Vincent Moutardier Dominique Lombardo Juan Lucio Iovanna Richard Tomasini Fabienne Guillaumond Matthew G. Vander Heiden Sophie Vasseur Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions Nature Communications
author_facet	Orianne Olivares Jared R. Mayers Victoire Gouirand Margaret E. Torrence Tristan Gicquel Laurence Borge Sophie Lac Julie Roques Marie-Noëlle Lavaut Patrice Berthezène Marion Rubis Veronique Secq Stéphane Garcia Vincent Moutardier Dominique Lombardo Juan Lucio Iovanna Richard Tomasini Fabienne Guillaumond Matthew G. Vander Heiden Sophie Vasseur
author_sort	Orianne Olivares
title	Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
title_short	Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
title_full	Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
title_fullStr	Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
title_full_unstemmed	Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
title_sort	collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-07-01
description	Cancer cells adapt their metabolism to survive limited nutrient availability. Here, the authors show that in conditions of limited glucose or glutamine availability, pancreatic ductal adenocarcinoma cells can use collagen-derived proline to foster the TCA cycle and allow cell survival bothin vitro and in vivo.
url	https://doi.org/10.1038/ncomms16031
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Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

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