The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development.
Coxsackievirus B (CVB) is an enterovirus that most commonly causes a self-limited febrile illness in infants, but cases of severe infection can manifest in acute myocarditis. Chronic consequences of mild CVB infection are unknown, though there is an epidemiologic association between early subclinica...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-07-01
|
Series: | PLoS Pathogens |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25079373/?tool=EBI |
id |
doaj-6a744a87bf434cc38dc1d9f8549437dd |
---|---|
record_format |
Article |
spelling |
doaj-6a744a87bf434cc38dc1d9f8549437dd2021-04-21T17:48:10ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742014-07-01107e100424910.1371/journal.ppat.1004249The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development.Jon SinJenna M PucciniChengqun HuangMathias H KonstandinPaul E GilbertMark A SussmanRoberta A GottliebRalph FeuerCoxsackievirus B (CVB) is an enterovirus that most commonly causes a self-limited febrile illness in infants, but cases of severe infection can manifest in acute myocarditis. Chronic consequences of mild CVB infection are unknown, though there is an epidemiologic association between early subclinical infections and late heart failure, raising the possibility of subtle damage leading to late-onset dysfunction, or chronic ongoing injury due to inflammatory reactions during latent infection. Here we describe a mouse model of juvenile infection with a subclinical dose of coxsackievirus B3 (CVB3) which showed no evident symptoms, either immediately following infection or in adult mice. However following physiological or pharmacologically-induced cardiac stress, juvenile-infected adult mice underwent cardiac hypertrophy and dilation indicative of progression to heart failure. Evaluation of the vasculature in the hearts of adult mice subjected to cardiac stress showed a compensatory increase in CD31+ blood vessel formation, although this effect was suppressed in juvenile-infected mice. Moreover, CVB3 efficiently infected juvenile c-kit+ cells, and cardiac progenitor cell numbers were reduced in the hearts of juvenile-infected adult mice. These results suggest that the exhausted cardiac progenitor cell pool following juvenile CVB3 infection may impair the heart's ability to increase capillary density to adapt to increased load.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25079373/?tool=EBI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jon Sin Jenna M Puccini Chengqun Huang Mathias H Konstandin Paul E Gilbert Mark A Sussman Roberta A Gottlieb Ralph Feuer |
spellingShingle |
Jon Sin Jenna M Puccini Chengqun Huang Mathias H Konstandin Paul E Gilbert Mark A Sussman Roberta A Gottlieb Ralph Feuer The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. PLoS Pathogens |
author_facet |
Jon Sin Jenna M Puccini Chengqun Huang Mathias H Konstandin Paul E Gilbert Mark A Sussman Roberta A Gottlieb Ralph Feuer |
author_sort |
Jon Sin |
title |
The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. |
title_short |
The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. |
title_full |
The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. |
title_fullStr |
The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. |
title_full_unstemmed |
The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. |
title_sort |
impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Pathogens |
issn |
1553-7366 1553-7374 |
publishDate |
2014-07-01 |
description |
Coxsackievirus B (CVB) is an enterovirus that most commonly causes a self-limited febrile illness in infants, but cases of severe infection can manifest in acute myocarditis. Chronic consequences of mild CVB infection are unknown, though there is an epidemiologic association between early subclinical infections and late heart failure, raising the possibility of subtle damage leading to late-onset dysfunction, or chronic ongoing injury due to inflammatory reactions during latent infection. Here we describe a mouse model of juvenile infection with a subclinical dose of coxsackievirus B3 (CVB3) which showed no evident symptoms, either immediately following infection or in adult mice. However following physiological or pharmacologically-induced cardiac stress, juvenile-infected adult mice underwent cardiac hypertrophy and dilation indicative of progression to heart failure. Evaluation of the vasculature in the hearts of adult mice subjected to cardiac stress showed a compensatory increase in CD31+ blood vessel formation, although this effect was suppressed in juvenile-infected mice. Moreover, CVB3 efficiently infected juvenile c-kit+ cells, and cardiac progenitor cell numbers were reduced in the hearts of juvenile-infected adult mice. These results suggest that the exhausted cardiac progenitor cell pool following juvenile CVB3 infection may impair the heart's ability to increase capillary density to adapt to increased load. |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25079373/?tool=EBI |
work_keys_str_mv |
AT jonsin theimpactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT jennampuccini theimpactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT chengqunhuang theimpactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT mathiashkonstandin theimpactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT paulegilbert theimpactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT markasussman theimpactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT robertaagottlieb theimpactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT ralphfeuer theimpactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT jonsin impactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT jennampuccini impactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT chengqunhuang impactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT mathiashkonstandin impactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT paulegilbert impactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT markasussman impactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT robertaagottlieb impactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment AT ralphfeuer impactofjuvenilecoxsackievirusinfectiononcardiacprogenitorcellsandpostnatalheartdevelopment |
_version_ |
1714665800762130432 |