Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression
Background: In the etiopathogenesis of autism spectrum disorder (ASD), it has been suggested that a proinflammatory condition, as well as an alteration in adhesion molecules in the early stages of neurodevelopment, may play a role in the pathophysiology of the disorder. This study set out to evaluat...
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Frontiers Media S.A.
2018-09-01
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Series: | Frontiers in Pediatrics |
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Online Access: | https://www.frontiersin.org/article/10.3389/fped.2018.00264/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonio Gomez-Fernandez Maria J. de la Torre-Aguilar Mercedes Gil-Campos Katherine Flores-Rojas Maria D. Cruz-Rico Pilar Martin-Borreguero Juan Luis Perez-Navero |
spellingShingle |
Antonio Gomez-Fernandez Maria J. de la Torre-Aguilar Mercedes Gil-Campos Katherine Flores-Rojas Maria D. Cruz-Rico Pilar Martin-Borreguero Juan Luis Perez-Navero Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression Frontiers in Pediatrics autism spectrum disorder cell adhesion molecules children cytokines neurodevelopmental regression |
author_facet |
Antonio Gomez-Fernandez Maria J. de la Torre-Aguilar Mercedes Gil-Campos Katherine Flores-Rojas Maria D. Cruz-Rico Pilar Martin-Borreguero Juan Luis Perez-Navero |
author_sort |
Antonio Gomez-Fernandez |
title |
Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression |
title_short |
Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression |
title_full |
Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression |
title_fullStr |
Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression |
title_full_unstemmed |
Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression |
title_sort |
children with autism spectrum disorder with regression exhibit a different profile in plasma cytokines and adhesion molecules compared to children without such regression |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2018-09-01 |
description |
Background: In the etiopathogenesis of autism spectrum disorder (ASD), it has been suggested that a proinflammatory condition, as well as an alteration in adhesion molecules in the early stages of neurodevelopment, may play a role in the pathophysiology of the disorder. This study set out to evaluate the plasma levels of certain inflammatory cytokines, adhesion molecules, and growth factors in a sample of pediatric patients with ASD and compare them to the levels in a control group of healthy children.Methods: Fifty-four children (45 males and nine females) aged 2-6, who were diagnosed with ASD, and a control group of 54 typically-developing children of similar ages were selected. The diagnosis of ASD was carried out in accordance with the DSM-5 criteria and the data obtained from a developmental semi-structured clinical interview and the ADOS evaluation test. Additional testing was carried out to identify the children's developmental level and severity of ASD symptomatology. Patients with ASD were further divided into two subgroups based on developmental parameters: ASD children with neurodevelopmental regression (AMR) and ASD children without neurodevelopmental regression (ANMR). Analyses of plasma molecules, such as cathepsin, IL1β, IL6, IL8, MPO, RANTES, MCP, BDNF, PAI NCAM, sICAM, sVCAM and NGF, were performed.Results: Higher levels of NGF were observed in the ASD group compared with the levels in the control group (p < 0.05). However, in the analysis of the ASD subgroups, lower plasma levels of NCAM and higher levels of NGF were found in the group of ASD children without developmental regression compared to the levels in the group of typically-developing children.Conclusions: These results suggest differences that could be related to different pathophysiological mechanisms in ASD. There is not a specific profile for the expression of relevant plasma cytokines, adhesion molecules or growth factors in children with ASD compared with that in typically-developing children. However, in the ANMR and AMR subgroups, some of the adhesion molecules and neuronal growth factors show differences that may be related to synaptogenesis. |
topic |
autism spectrum disorder cell adhesion molecules children cytokines neurodevelopmental regression |
url |
https://www.frontiersin.org/article/10.3389/fped.2018.00264/full |
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doaj-6a77bdbf8938442a91ef185a245dea1b2020-11-24T23:39:31ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602018-09-01610.3389/fped.2018.00264412188Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such RegressionAntonio Gomez-Fernandez0Maria J. de la Torre-Aguilar1Mercedes Gil-Campos2Katherine Flores-Rojas3Maria D. Cruz-Rico4Pilar Martin-Borreguero5Juan Luis Perez-Navero6Department of Pediatrics, Reina Sofia University Hospital, University of Córdoba, Maimónides Institute for Biomedical Research of Córdoba (IMIBIC), Cordoba, SpainDepartment of Pediatrics, Reina Sofia University Hospital, University of Córdoba, Maimónides Institute for Biomedical Research of Córdoba (IMIBIC), Cordoba, SpainPediatric Metabolism Unit, Reina Sofia University Hospital, Maimónides Institute for Biomedical Research of Córdoba (IMIBIC), University of Córdoba, Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Cordoba, SpainPediatric Metabolism Unit, Reina Sofia University Hospital, Maimónides Institute for Biomedical Research of Córdoba (IMIBIC), University of Córdoba, Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Cordoba, SpainDepartment of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Center of Biomedical Research, University of Granada, Granada, SpainDepartment of Child and Adolescent Clinical Psychiatry and Psychology, Reina Sofia University Hospital, Maimónides Institute for Biomedical Research of Córdoba (IMIBIC), Cordoba, SpainDepartment of Pediatrics, Reina Sofia University Hospital, University of Córdoba, Maimónides Institute for Biomedical Research of Córdoba (IMIBIC), Cordoba, SpainBackground: In the etiopathogenesis of autism spectrum disorder (ASD), it has been suggested that a proinflammatory condition, as well as an alteration in adhesion molecules in the early stages of neurodevelopment, may play a role in the pathophysiology of the disorder. This study set out to evaluate the plasma levels of certain inflammatory cytokines, adhesion molecules, and growth factors in a sample of pediatric patients with ASD and compare them to the levels in a control group of healthy children.Methods: Fifty-four children (45 males and nine females) aged 2-6, who were diagnosed with ASD, and a control group of 54 typically-developing children of similar ages were selected. The diagnosis of ASD was carried out in accordance with the DSM-5 criteria and the data obtained from a developmental semi-structured clinical interview and the ADOS evaluation test. Additional testing was carried out to identify the children's developmental level and severity of ASD symptomatology. Patients with ASD were further divided into two subgroups based on developmental parameters: ASD children with neurodevelopmental regression (AMR) and ASD children without neurodevelopmental regression (ANMR). Analyses of plasma molecules, such as cathepsin, IL1β, IL6, IL8, MPO, RANTES, MCP, BDNF, PAI NCAM, sICAM, sVCAM and NGF, were performed.Results: Higher levels of NGF were observed in the ASD group compared with the levels in the control group (p < 0.05). However, in the analysis of the ASD subgroups, lower plasma levels of NCAM and higher levels of NGF were found in the group of ASD children without developmental regression compared to the levels in the group of typically-developing children.Conclusions: These results suggest differences that could be related to different pathophysiological mechanisms in ASD. There is not a specific profile for the expression of relevant plasma cytokines, adhesion molecules or growth factors in children with ASD compared with that in typically-developing children. However, in the ANMR and AMR subgroups, some of the adhesion molecules and neuronal growth factors show differences that may be related to synaptogenesis.https://www.frontiersin.org/article/10.3389/fped.2018.00264/fullautism spectrum disordercell adhesion moleculeschildrencytokinesneurodevelopmental regression |