Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes?
Several studies highlighted the importance of the interaction between microbiota and the immune system in the development and maintenance of the homeostasis of the human organism. Dysbiosis is associated with proinflammatory and pathological state-like metabolic diseases, autoimmune diseases and HIV...
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doaj-6a84dfc70fcf4223b4b2478aaffa77da2020-11-25T02:32:55ZengMDPI AGNutrients2072-66432019-11-011111262910.3390/nu11112629nu11112629Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes?Chiara Pellicano0Giorgia Leodori1Giuseppe Pietro Innocenti2Antonietta Gigante3Edoardo Rosato4Department of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome ItalyDepartment of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, 00185 Rome, ItalySeveral studies highlighted the importance of the interaction between microbiota and the immune system in the development and maintenance of the homeostasis of the human organism. Dysbiosis is associated with proinflammatory and pathological state-like metabolic diseases, autoimmune diseases and HIV infection. In this review, we discuss the current understanding of the possible role of dysbiosis in triggering and/or exacerbating symptoms of autoimmune diseases and HIV infection. There are no data about the influence of the microbiome on the development of autoimmune diseases during HIV infection. We can hypothesize that untreated patients may be more susceptible to the development of autoimmune diseases, due to the presence of dysbiosis. Eubiosis, re-established by probiotic administration, can be used to reduce triggers for autoimmune diseases in untreated HIV patients, although clinical studies are needed to evaluate the role of the microbiome in autoimmune diseases in HIV patients.https://www.mdpi.com/2072-6643/11/11/2629microbiotaautoimmune diseaseshiveubiosisdysbiosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chiara Pellicano Giorgia Leodori Giuseppe Pietro Innocenti Antonietta Gigante Edoardo Rosato |
spellingShingle |
Chiara Pellicano Giorgia Leodori Giuseppe Pietro Innocenti Antonietta Gigante Edoardo Rosato Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes? Nutrients microbiota autoimmune diseases hiv eubiosis dysbiosis |
author_facet |
Chiara Pellicano Giorgia Leodori Giuseppe Pietro Innocenti Antonietta Gigante Edoardo Rosato |
author_sort |
Chiara Pellicano |
title |
Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes? |
title_short |
Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes? |
title_full |
Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes? |
title_fullStr |
Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes? |
title_full_unstemmed |
Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes? |
title_sort |
microbiome, autoimmune diseases and hiv infection: friends or foes? |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-11-01 |
description |
Several studies highlighted the importance of the interaction between microbiota and the immune system in the development and maintenance of the homeostasis of the human organism. Dysbiosis is associated with proinflammatory and pathological state-like metabolic diseases, autoimmune diseases and HIV infection. In this review, we discuss the current understanding of the possible role of dysbiosis in triggering and/or exacerbating symptoms of autoimmune diseases and HIV infection. There are no data about the influence of the microbiome on the development of autoimmune diseases during HIV infection. We can hypothesize that untreated patients may be more susceptible to the development of autoimmune diseases, due to the presence of dysbiosis. Eubiosis, re-established by probiotic administration, can be used to reduce triggers for autoimmune diseases in untreated HIV patients, although clinical studies are needed to evaluate the role of the microbiome in autoimmune diseases in HIV patients. |
topic |
microbiota autoimmune diseases hiv eubiosis dysbiosis |
url |
https://www.mdpi.com/2072-6643/11/11/2629 |
work_keys_str_mv |
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