Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy
Dendritic cells (DCs) are a type of an antigen-presenting cell which undertake a job on capturing antigens coming from pathogens or tumors and presenting to T cells for immune response. The metabolism of DCs controls its development, polarization, and maturation processes and provides energy support...
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2021-02-01
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doaj-6a8caadfb67c4905900b902bcead638d2021-02-24T06:08:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011210.3389/fimmu.2021.613492613492Metabolism of Dendritic Cells in Tumor Microenvironment: For ImmunotherapyXin Peng0Youe He1Youe He2Jun Huang3Yongguang Tao4Yongguang Tao5Yongguang Tao6Shuang Liu7Shuang Liu8Shuang Liu9Department of Oncology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Translational Medicine, Cancer Biological Treatment Center, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaKey Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaKey Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, Department of Thoracic Surgery, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Oncology, Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDendritic cells (DCs) are a type of an antigen-presenting cell which undertake a job on capturing antigens coming from pathogens or tumors and presenting to T cells for immune response. The metabolism of DCs controls its development, polarization, and maturation processes and provides energy support for its functions. However, the immune activity of DCs in tumor microenvironment (TME) is inhibited generally. Abnormal metabolism of tumor cells causes metabolic changes in TME, such as hyperglycolysis, lactate and lipid accumulation, acidification, tryptophan deprivation, which limit the function of DCs and lead to the occurrence of tumor immune escape. Combined metabolic regulation with immunotherapy can strengthen the ability of antigen-presentation and T cell activation of DCs, improve the existing anti-tumor therapy, and overcome the defects of DC-related therapies in the current stage, which has great potential in oncology therapy. Therefore, we reviewed the glucose, lipid, and amino acid metabolism of DCs, as well as the metabolic changes after being affected by TME. Together with the potential metabolic targets of DCs, possible anti-tumor therapeutic pathways were summarized.https://www.frontiersin.org/articles/10.3389/fimmu.2021.613492/fulldendritic cellstumor microenvironmentmetabolismglucoseamino acidlipid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xin Peng Youe He Youe He Jun Huang Yongguang Tao Yongguang Tao Yongguang Tao Shuang Liu Shuang Liu Shuang Liu |
spellingShingle |
Xin Peng Youe He Youe He Jun Huang Yongguang Tao Yongguang Tao Yongguang Tao Shuang Liu Shuang Liu Shuang Liu Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy Frontiers in Immunology dendritic cells tumor microenvironment metabolism glucose amino acid lipid |
author_facet |
Xin Peng Youe He Youe He Jun Huang Yongguang Tao Yongguang Tao Yongguang Tao Shuang Liu Shuang Liu Shuang Liu |
author_sort |
Xin Peng |
title |
Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy |
title_short |
Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy |
title_full |
Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy |
title_fullStr |
Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy |
title_full_unstemmed |
Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy |
title_sort |
metabolism of dendritic cells in tumor microenvironment: for immunotherapy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-02-01 |
description |
Dendritic cells (DCs) are a type of an antigen-presenting cell which undertake a job on capturing antigens coming from pathogens or tumors and presenting to T cells for immune response. The metabolism of DCs controls its development, polarization, and maturation processes and provides energy support for its functions. However, the immune activity of DCs in tumor microenvironment (TME) is inhibited generally. Abnormal metabolism of tumor cells causes metabolic changes in TME, such as hyperglycolysis, lactate and lipid accumulation, acidification, tryptophan deprivation, which limit the function of DCs and lead to the occurrence of tumor immune escape. Combined metabolic regulation with immunotherapy can strengthen the ability of antigen-presentation and T cell activation of DCs, improve the existing anti-tumor therapy, and overcome the defects of DC-related therapies in the current stage, which has great potential in oncology therapy. Therefore, we reviewed the glucose, lipid, and amino acid metabolism of DCs, as well as the metabolic changes after being affected by TME. Together with the potential metabolic targets of DCs, possible anti-tumor therapeutic pathways were summarized. |
topic |
dendritic cells tumor microenvironment metabolism glucose amino acid lipid |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.613492/full |
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