Modeling the dynamics of Lassa fever in Nigeria

• Main Authors: Mayowa M. Ojo, B. Gbadamosi, Temitope O. Benson, O. Adebimpe, A. L. Georgina
• Format: Article
• Language: English
• Published: SpringerOpen 2021-07-01
• Series: Journal of the Egyptian Mathematical Society
• Subjects: Lassa fever; Reproduction number; Stability; Model fitting; Sensitivity analysis; Numerical simulation
• Online Access: https://doi.org/10.1186/s42787-021-00124-9

Abstract Lassa fever is a zoonotic disease spread by infected rodents known as multimammate rats. The disease has posed a significant and major health challenge in West African countries, including Nigeria. To have a deeper understanding of Lassa fever epidemiology in Nigeria, we present a deterministic dynamical model to study its dynamical transmission behavior in the population. To mimic the disease’s biological history, we divide the population into two groups: humans and rodents. We established the quantity known as reproduction number $${\mathcal {R}}_{0}$$ R 0 . The results show that if $${\mathcal {R}}_{0} <1$$ R 0 < 1 then the system is stable, otherwise it is unstable. The model fitting was performed using the nonlinear least square method on cumulative reported cases from Nigeria between 2018 and 2020 to obtain the best fit that describes the dynamics of this disease in Nigeria. In addition, sensitivity analysis was performed, and the numerical solution of the system was derived using an iterative scheme, the fifth-order Runge–Kutta method. Using different numeric values for each parameter, we investigate the effect of all highest sensitivity indices’ parameters on the population of infected humans and infected rodents. Our findings indicate that any control strategies and methods that reduce rodent populations and the risk of transmission from rodents to humans and rodents would aid in the population’s control of Lassa fever.