Virtual Screen for Repurposing of Drugs for Candidate Influenza a M2 Ion-Channel Inhibitors

Virtual Screen for Repurposing of Drugs for Candidate Influenza a M2 Ion-Channel Inhibitors

Influenza A virus (IAV) matrix protein 2 (M2), an ion channel, is crucial for virus infection, and therefore, an important anti-influenza drug target. Adamantanes, also known as M2 channel blockers, are one of the two classes of Food and Drug Administration-approved anti-influenza drugs, although th...

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Bibliographic Details
Main Authors: Draginja Radosevic, Milan Sencanski, Vladimir Perovic, Nevena Veljkovic, Jelena Prljic, Veljko Veljkovic, Emily Mantlo, Natalya Bukreyeva, Slobodan Paessler, Sanja Glisic
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
influenza A
IAV matrix protein 2
drug repurposing
virtual screening
drug resistance
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00067/full

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