Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference
RNA interference (RNAi) is a potent mechanism that silences mRNA and protein expression in all cells and tissue types. RNAi is known to exert many of its functional effects in the cytoplasm, and thus, the cellular localization of target mRNA may impact observed potency. Here, we demonstrate that cel...
Main Authors: | Chantal M. Ferguson, Dimas Echeverria, Matthew Hassler, Socheata Ly, Anastasia Khvorova |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-09-01
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Series: | Molecular Therapy: Nucleic Acids |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253120301670 |
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