MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer

Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characteriz...

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Main Authors:	Jakub Godlewski, Ruben Ferrer-Luna, Arun K. Rooj, Marco Mineo, Franz Ricklefs, Yuji S. Takeda, M. Oskar Nowicki, Elżbieta Salińska, Ichiro Nakano, Hakho Lee, Ralph Weissleder, Rameen Beroukhim, E. Antonio Chiocca, Agnieszka Bronisz
Format:	Article
Language:	English
Published:	Elsevier 2017-06-01
Series:	Stem Cell Reports
Subjects:	cancer stem cells subtypes glioblastoma GBM cancer heterogeneity microRNA exosomes extracellular vesicles
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671117301789

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spelling	doaj-6a981b2fa5054d1bbf381dcaaae8eaed2020-11-24T22:52:25ZengElsevierStem Cell Reports2213-67112017-06-01861497150510.1016/j.stemcr.2017.04.024MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular TransferJakub Godlewski0Ruben Ferrer-Luna1Arun K. Rooj2Marco Mineo3Franz Ricklefs4Yuji S. Takeda5M. Oskar Nowicki6Elżbieta Salińska7Ichiro Nakano8Hakho Lee9Ralph Weissleder10Rameen Beroukhim11E. Antonio Chiocca12Agnieszka Bronisz13Department of Neurosurgery, Harvey Cushing Neuro-oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Cancer Program, BROAD Institute of MIT and Harvard, Cambridge, MA 02142, USADepartment of Neurosurgery, Harvey Cushing Neuro-oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Harvey Cushing Neuro-oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Harvey Cushing Neuro-oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Harvey Cushing Neuro-oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Harvey Cushing Neuro-oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences 02-106 Warsaw, PolandDepartment of Neurosurgery and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35243, USACenter for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USADepartment of Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USADepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Cancer Program, BROAD Institute of MIT and Harvard, Cambridge, MA 02142, USADepartment of Neurosurgery, Harvey Cushing Neuro-oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, Harvey Cushing Neuro-oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USADespite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells (GSCs). As EVs and microRNAs convey information that rearranges the molecular landscape in a cell type-specific manner, we argue that intratumoral exchange of microRNA augments the heterogeneity of GSC that is reflected in highly heterogeneous profile of microRNA expression in GBM subtypes.http://www.sciencedirect.com/science/article/pii/S2213671117301789cancer stem cellssubtypesglioblastomaGBMcancer heterogeneitymicroRNAexosomesextracellular vesicles
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jakub Godlewski Ruben Ferrer-Luna Arun K. Rooj Marco Mineo Franz Ricklefs Yuji S. Takeda M. Oskar Nowicki Elżbieta Salińska Ichiro Nakano Hakho Lee Ralph Weissleder Rameen Beroukhim E. Antonio Chiocca Agnieszka Bronisz
spellingShingle	Jakub Godlewski Ruben Ferrer-Luna Arun K. Rooj Marco Mineo Franz Ricklefs Yuji S. Takeda M. Oskar Nowicki Elżbieta Salińska Ichiro Nakano Hakho Lee Ralph Weissleder Rameen Beroukhim E. Antonio Chiocca Agnieszka Bronisz MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer Stem Cell Reports cancer stem cells subtypes glioblastoma GBM cancer heterogeneity microRNA exosomes extracellular vesicles
author_facet	Jakub Godlewski Ruben Ferrer-Luna Arun K. Rooj Marco Mineo Franz Ricklefs Yuji S. Takeda M. Oskar Nowicki Elżbieta Salińska Ichiro Nakano Hakho Lee Ralph Weissleder Rameen Beroukhim E. Antonio Chiocca Agnieszka Bronisz
author_sort	Jakub Godlewski
title	MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer
title_short	MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer
title_full	MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer
title_fullStr	MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer
title_full_unstemmed	MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer
title_sort	microrna signatures and molecular subtypes of glioblastoma: the role of extracellular transfer
publisher	Elsevier
series	Stem Cell Reports
issn	2213-6711
publishDate	2017-06-01
description	Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells (GSCs). As EVs and microRNAs convey information that rearranges the molecular landscape in a cell type-specific manner, we argue that intratumoral exchange of microRNA augments the heterogeneity of GSC that is reflected in highly heterogeneous profile of microRNA expression in GBM subtypes.
topic	cancer stem cells subtypes glioblastoma GBM cancer heterogeneity microRNA exosomes extracellular vesicles
url	http://www.sciencedirect.com/science/article/pii/S2213671117301789
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MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer

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