The Interactions of DNA Repair, Telomere Homeostasis, and p53 Mutational Status in Solid Cancers: Risk, Prognosis, and Prediction

The Interactions of DNA Repair, Telomere Homeostasis, and p53 Mutational Status in Solid Cancers: Risk, Prognosis, and Prediction

The disruption of genomic integrity due to the accumulation of various kinds of DNA damage, deficient DNA repair capacity, and telomere shortening constitute the hallmarks of malignant diseases. DNA damage response (DDR) is a signaling network to process DNA damage with importance for both cancer de...

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Bibliographic Details
Main Authors: Pavel Vodicka, Ladislav Andera, Alena Opattova, Ludmila Vodickova
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
interactions
DNA damage response
telomere homeostasis
<i>TP53</i> mutational status
cancer risk
cancer progression
Online Access:https://www.mdpi.com/2072-6694/13/3/479

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