One Dose of Staphylococcus aureus 4C-Staph Vaccine Formulated with a Novel TLR7-Dependent Adjuvant Rapidly Protects Mice through Antibodies, Effector CD4+ T Cells, and IL-17A.

One Dose of Staphylococcus aureus 4C-Staph Vaccine Formulated with a Novel TLR7-Dependent Adjuvant Rapidly Protects Mice through Antibodies, Effector CD4+ T Cells, and IL-17A.

A rapidly acting, single dose vaccine against Staphylococcus aureus would be highly beneficial for patients scheduled for major surgeries or in intensive care units. Here we show that one immunization with a multicomponent S. aureus candidate vaccine, 4C-Staph, formulated with a novel TLR7-dependent...

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Bibliographic Details
Main Authors: Francesca Mancini, Elisabetta Monaci, Giuseppe Lofano, Antonina Torre, Marta Bacconi, Simona Tavarini, Chiara Sammicheli, Letizia Arcidiacono, Bruno Galletti, Donatello Laera, Michele Pallaoro, Giovanna Tuscano, Maria Rita Fontana, Giuliano Bensi, Guido Grandi, Silvia Rossi-Paccani, Sandra Nuti, Rino Rappuoli, Ennio De Gregorio, Fabio Bagnoli, Elisabetta Soldaini, Sylvie Bertholet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4727907?pdf=render

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