Neutrophil Maturation and Survival Is Controlled by IFN-Dependent Regulation of NAMPT Signaling

Neutrophil Maturation and Survival Is Controlled by IFN-Dependent Regulation of NAMPT Signaling

Granulocyte-colony stimulating factor (G-CSF)/nicotinamide phosphoribosyltransferase (NAMPT) signaling has been shown to be crucial for the modulation of neutrophil development and functionality. As this signaling pathway is significantly suppressed by type I interferons (IFNs), we aimed to study ho...

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Bibliographic Details
Main Authors: Elena Siakaeva, Ekaterina Pylaeva, Ilona Spyra, Sharareh Bordbari, Benedikt Höing, Cornelius Kürten, Stephan Lang, Jadwiga Jablonska
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
Subjects:
nampt
type i interferons
granulopoiesis
neutrophil progenitors
neutrophil maturation and survival
apoptosis
Online Access:https://www.mdpi.com/1422-0067/20/22/5584

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