Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing

Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing

<p>Abstract</p> <p>Background</p> <p>Many hypothesis-driven genetic studies require the ability to comprehensively and efficiently target specific regions of the genome to detect sequence variations. Often, sample availability is limited requiring the use of whole genom...

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Bibliographic Details
Main Authors: ElSharawy Abdou, Warner Jason, Olson Jeff, Forster Michael, Schilhabel Markus B, Link Darren R, Rose-John Stefan, Schreiber Stefan, Rosenstiel Philip, Brayer James, Franke Andre
Format: Article
Language:English
Published: BMC 2012-09-01
Series:BMC Genomics
Subjects:
High-throughput targeted next-generation resequencing
Microdroplet-based multiplex PCR
Sample pooling or multiplexing
Whole-genome amplified DNA samples
Cost reduction
Online Access:http://www.biomedcentral.com/1471-2164/13/500

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http://www.biomedcentral.com/1471-2164/13/500

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