Pathologic and biochemical characterization of PrPSc from elk with PRNP polymorphisms at codon 132 after experimental infection with the chronic wasting disease agent

Pathologic and biochemical characterization of PrPSc from elk with PRNP polymorphisms at codon 132 after experimental infection with the chronic wasting disease agent

Abstract Background The Rocky Mountain elk (Cervus elaphus nelsoni) prion protein gene (PRNP) is polymorphic at codon 132, with leucine (L132) and methionine (M132) allelic variants present in the population. In elk experimentally inoculated with the chronic wasting disease (CWD) agent, different in...

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Bibliographic Details
Main Authors: S. Jo Moore, Catherine E. Vrentas, Soyoun Hwang, M. Heather West Greenlee, Eric M. Nicholson, Justin J. Greenlee
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Veterinary Research
Subjects:
Chronic wasting disease
Conformational stability
Elk
RT-QuIC
Prion protein
Online Access:http://link.springer.com/article/10.1186/s12917-018-1400-9

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