Correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutol
<div class="WordSection1"><p><strong>Background:</strong> Recent animal studies revealed the decreased amount of retinal ganglion cells after treatment with ethambutol. The aim of this study was to evaluate the changes of peripapillary retinal nerve fiber layer (RNF...
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Faculty of Medicine Universitas Indonesia
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doaj-6acdf26628e54a60a8587a29fd23aef42020-11-25T01:50:35ZengFaculty of Medicine Universitas Indonesia Medical Journal of Indonesia0853-17732252-80832015-04-01241192310.13181/mji.v24i1.10651069Correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutolDialika Dialika0Muhammad Sidik1Syntia Nusanti2Aria KekalihDepartment of Ophthalmology, Faculty of Medicine, Universitas Indonesia, JakartaDepartment of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, JakartaDepartment of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta<div class="WordSection1"><p><strong>Background:</strong> Recent animal studies revealed the decreased amount of retinal ganglion cells after treatment with ethambutol. The aim of this study was to evaluate the changes of peripapillary retinal nerve fiber layer (RNFL) thickness in patients receiving ethambutol therapy, as well as to know the correlation of RNFL thickness changes with the changes of visual function.</p><p><strong>Methods:</strong> This was a cohort study on 29 subjects at one tuberculosis treatment center, Jakarta. Subjects underwent RNFL thickness measurement using optical coherence tomography (OCT) and several visual function parameters (visual acuity, contrast sensitivity, color sensitivity and visual field) before and two-months following ethambutol therapy. Statistical comparison between pre- and post- ethambutol measurements were done using either paired T-test or Wilcoxon test. Correlations between anatomical and functional changes were assessed with Spearman correlation test. </p><p><strong>Results:</strong> There were significant changes of peripapillary RNFL thickness in superior (147 and 141 μm, p = 0.001), nasal (92 and 88 μm, p = 0.045) quadrants and average RNFL thickness (116.77 and 112.65 μm, p = 0.001). No significant correlation between RNFL thickness changes and the changes of visual function parameters (p > 0.05).</p><p><strong>Conclusion:</strong> Ethambutol consumption for two months in recommended dose is still considered safe to human retina and visual status.</p></div>http://mji.ui.ac.id/journal/index.php/mji/article/view/1065ethambutoloptical coherence tomographyoptic neuropathyretinal nerve |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dialika Dialika Muhammad Sidik Syntia Nusanti Aria Kekalih |
spellingShingle |
Dialika Dialika Muhammad Sidik Syntia Nusanti Aria Kekalih Correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutol Medical Journal of Indonesia ethambutol optical coherence tomography optic neuropathy retinal nerve |
author_facet |
Dialika Dialika Muhammad Sidik Syntia Nusanti Aria Kekalih |
author_sort |
Dialika Dialika |
title |
Correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutol |
title_short |
Correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutol |
title_full |
Correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutol |
title_fullStr |
Correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutol |
title_full_unstemmed |
Correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutol |
title_sort |
correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutol |
publisher |
Faculty of Medicine Universitas Indonesia |
series |
Medical Journal of Indonesia |
issn |
0853-1773 2252-8083 |
publishDate |
2015-04-01 |
description |
<div class="WordSection1"><p><strong>Background:</strong> Recent animal studies revealed the decreased amount of retinal ganglion cells after treatment with ethambutol. The aim of this study was to evaluate the changes of peripapillary retinal nerve fiber layer (RNFL) thickness in patients receiving ethambutol therapy, as well as to know the correlation of RNFL thickness changes with the changes of visual function.</p><p><strong>Methods:</strong> This was a cohort study on 29 subjects at one tuberculosis treatment center, Jakarta. Subjects underwent RNFL thickness measurement using optical coherence tomography (OCT) and several visual function parameters (visual acuity, contrast sensitivity, color sensitivity and visual field) before and two-months following ethambutol therapy. Statistical comparison between pre- and post- ethambutol measurements were done using either paired T-test or Wilcoxon test. Correlations between anatomical and functional changes were assessed with Spearman correlation test. </p><p><strong>Results:</strong> There were significant changes of peripapillary RNFL thickness in superior (147 and 141 μm, p = 0.001), nasal (92 and 88 μm, p = 0.045) quadrants and average RNFL thickness (116.77 and 112.65 μm, p = 0.001). No significant correlation between RNFL thickness changes and the changes of visual function parameters (p > 0.05).</p><p><strong>Conclusion:</strong> Ethambutol consumption for two months in recommended dose is still considered safe to human retina and visual status.</p></div> |
topic |
ethambutol optical coherence tomography optic neuropathy retinal nerve |
url |
http://mji.ui.ac.id/journal/index.php/mji/article/view/1065 |
work_keys_str_mv |
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