Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors

Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors

The K<sup>+</sup>-sparing diuretic amiloride shows off-target anti-cancer effects in multiple rodent models. These effects arise from the inhibition of two distinct cancer targets: the trypsin-like serine protease urokinase-type plasminogen activator (uPA), a cell-surface mediator of mat...

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Bibliographic Details
Main Authors: Benjamin J. Buckley, Ashna Kumar, Ashraf Aboelela, Richard S. Bujaroski, Xiuju Li, Hiwa Majed, Larry Fliegel, Marie Ranson, Michael J. Kelso
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
sodium-hydrogen exchanger isoform-1
NHE1
amiloride
urokinase-type plasminogen activator
uPA
cancer
Online Access:https://www.mdpi.com/1422-0067/22/6/2999

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