Assessment of Aurora a Kinase Expression in Breast Cancer: A Tool for Early Diagnosis?
Aurora A kinase is overexpressed in many cancers but the status of this protein in the breast cancer often varies. We investigate the expression and localization of Aurora A protein in relation with tumor emergence and progression in breast cancer. Aurora A kinase status was evaluated in 107 patient...
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Online Access: | http://dx.doi.org/10.3233/DMA-120947 |
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doaj-6ae01d22f4bb450bb0c39135970ac3912020-11-24T22:25:05ZengHindawi LimitedDisease Markers0278-02401875-86302013-01-01342636910.3233/DMA-120947Assessment of Aurora a Kinase Expression in Breast Cancer: A Tool for Early Diagnosis?Imen Ferchichi0Samia Sassi Hannachi1Amal Baccar2Raja Marrakchi Triki3Jean Yves Cremet4Khaled Ben Romdhane5Claude Prigent6Amel Ben Ammar El Gaaied7Laboratory of Genetics, Immunology and Human Pathology, Department of Biology, Faculty of Sciences of Tunis, Tunis, TunisiaDepartment of Histopathology, The Oncology Institute of Saleh Azaïez, Bab Saadoun, Tunis, TunisiaLaboratory of Genetics, Immunology and Human Pathology, Department of Biology, Faculty of Sciences of Tunis, Tunis, TunisiaLaboratory of Genetics, Immunology and Human Pathology, Department of Biology, Faculty of Sciences of Tunis, Tunis, TunisiaThe Institute of Genetics and Development of Rennes, UMR 6061, Rennes Cedex, FranceDepartment of Histopathology, The Oncology Institute of Saleh Azaïez, Bab Saadoun, Tunis, TunisiaThe Institute of Genetics and Development of Rennes, UMR 6061, Rennes Cedex, FranceLaboratory of Genetics, Immunology and Human Pathology, Department of Biology, Faculty of Sciences of Tunis, Tunis, TunisiaAurora A kinase is overexpressed in many cancers but the status of this protein in the breast cancer often varies. We investigate the expression and localization of Aurora A protein in relation with tumor emergence and progression in breast cancer. Aurora A kinase status was evaluated in 107 patients using immunohistochemistry. The experimental findings showed that high expression of the Aurora A protein was correlated with elevated nuclear grade, low expression of progesterone receptor and positive nodal status. The experimental results showed also that the localization of this kinase shifts from cytoplasm in non malignant adjacent tissue to both cytoplasmic and nuclear compartments in tumoral tissue, suggesting an oncogenic role of the nuclear accumulation. We have, furthermore, detected the overexpression of this protein in non malignant adjacent tissue. The expression of the Aurora A kinase in non malignant tissue may represent an earlier diagnosis tool for breast cancer.http://dx.doi.org/10.3233/DMA-120947 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Imen Ferchichi Samia Sassi Hannachi Amal Baccar Raja Marrakchi Triki Jean Yves Cremet Khaled Ben Romdhane Claude Prigent Amel Ben Ammar El Gaaied |
spellingShingle |
Imen Ferchichi Samia Sassi Hannachi Amal Baccar Raja Marrakchi Triki Jean Yves Cremet Khaled Ben Romdhane Claude Prigent Amel Ben Ammar El Gaaied Assessment of Aurora a Kinase Expression in Breast Cancer: A Tool for Early Diagnosis? Disease Markers |
author_facet |
Imen Ferchichi Samia Sassi Hannachi Amal Baccar Raja Marrakchi Triki Jean Yves Cremet Khaled Ben Romdhane Claude Prigent Amel Ben Ammar El Gaaied |
author_sort |
Imen Ferchichi |
title |
Assessment of Aurora a Kinase Expression in Breast Cancer: A Tool for Early Diagnosis? |
title_short |
Assessment of Aurora a Kinase Expression in Breast Cancer: A Tool for Early Diagnosis? |
title_full |
Assessment of Aurora a Kinase Expression in Breast Cancer: A Tool for Early Diagnosis? |
title_fullStr |
Assessment of Aurora a Kinase Expression in Breast Cancer: A Tool for Early Diagnosis? |
title_full_unstemmed |
Assessment of Aurora a Kinase Expression in Breast Cancer: A Tool for Early Diagnosis? |
title_sort |
assessment of aurora a kinase expression in breast cancer: a tool for early diagnosis? |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2013-01-01 |
description |
Aurora A kinase is overexpressed in many cancers but the status of this protein in the breast cancer often varies. We investigate the expression and localization of Aurora A protein in relation with tumor emergence and progression in breast cancer. Aurora A kinase status was evaluated in 107 patients using immunohistochemistry. The experimental findings showed that high expression of the Aurora A protein was correlated with elevated nuclear grade, low expression of progesterone receptor and positive nodal status. The experimental results showed also that the localization of this kinase shifts from cytoplasm in non malignant adjacent tissue to both cytoplasmic and nuclear compartments in tumoral tissue, suggesting an oncogenic role of the nuclear accumulation. We have, furthermore, detected the overexpression of this protein in non malignant adjacent tissue. The expression of the Aurora A kinase in non malignant tissue may represent an earlier diagnosis tool for breast cancer. |
url |
http://dx.doi.org/10.3233/DMA-120947 |
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