ANEMIA SEL SABIT
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Universitas Udayana
2013-09-01
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Online Access: | http://ojs.unud.ac.id/index.php/eum/article/view/6292 |
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doaj-6ae29c0eef8a45e5bd09265d38637fe22020-11-24T23:25:46ZengUniversitas Udayanae-Jurnal Medika Udayana2303-13952013-09-0129147814895716ANEMIA SEL SABITGede Agus SuwiryawanI Wayan Putu Sutirta YasaDAP Rasmika Dewi<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> <w:UseFELayout /> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--> <p class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><span class="hps"><span style="mso-ansi-language: EN;" lang="EN">Anemia</span></span><span style="mso-ansi-language: EN;" lang="EN"> <span class="hps">is a form</span> <span class="hps">of blood</span> <span class="hps">disorder</span> <span class="hps">most</span> <span class="hps">often occurs in</span> <span class="hps">the community</span>. <span class="hps">Sickle cell anemia</span> <span class="hps">is</span> <span class="hps">anemia</span> <span class="hps">due to</span> <span class="hps">hemoglobinopathy</span> <span class="hps">caused by</span> <span class="hps">a change in</span> <span class="hps">the</span> <span class="hps">amino</span> <span class="hps">acid</span>-6 <span class="hps">of the</span> <span class="hps">?</span> <span class="hps">globin</span> <span class="hps">chain</span>. <span class="hps">Sickle cell anemia is</span> <span class="hps">common in</span> <span class="hps">tropical areas of</span> <span class="hps">Africa</span> <span class="hps">and some parts of</span> <span class="hps">the region</span> <span class="hps">Saudi</span> <span class="hps">Arabia</span>, <span class="hps">India</span> <span class="hps">and the</span> <span class="hps">Mediterranean</span> <span class="hps">as well as</span> <span class="hps">black</span> <span class="hps">people</span> <span class="hps">in America.</span> <span class="hps">In addition there are</span> <span class="hps">also</span> <span class="hps">careers</span> <span class="hps">in various European countries</span>. <span class="hps">In</span> <span class="hps">pathophysiology</span>, <span class="hps">there are</span> <span class="hps">amino</span> <span class="hps">acid change</span> <span class="hps">from</span> <span class="hps">glutamic</span> <span class="hps">acid</span> <span class="hps">to</span> <span class="hps">valine</span> <span class="hps">in the</span> <span class="hps">?</span>-globin <span class="hps">chain</span> <span class="hps">that causes</span> <span class="hps">red blood cells become</span> <span class="hps">sickle-shaped</span> <span class="hps">when deoxygenatied</span>, <span class="hps">but</span> <span class="hps">still</span> <span class="hps">be able to return</span> <span class="hps">to its normal shape</span> <span class="hps">when experiencing</span> <span class="hps">oxygenation</span>. <span class="hps">When the</span> <span class="hps">red blood cell membrane</span> <span class="hps">have been amended</span>, the <span class="hps">polymerization</span> <span class="hps">of red</span> <span class="hps">blood</span> <span class="hps">cells</span> <span class="hps">has become</span> <span class="hps">irreversible</span>. <span class="hps">Clinical picture</span> <span class="hps">seen in</span> <span class="hps">sickle</span> <span class="hps">cell</span> <span class="hps">anemia</span> <span class="hps">can be divided into</span> <span class="hps">two</span>, <span class="hps">namely:</span> <span class="hps">acute</span> <span class="hps">and chronic</span>. <span class="hps">Diagnosis</span> <span class="hps">can be done is</span> <span class="hps">to</span> <span class="hps">distinguish</span> <span class="hps">between</span> <span class="hps">heterozygous</span> <span class="hps">or</span> <span class="hps">homozygous</span> <span class="hps">sickle</span> <span class="hps">cell</span>. T<span class="hps">reatment</span> provided <span class="hps">in accordance</span> <span class="hps">with the clinical picture</span> <span class="hps">appears</span>. <span class="hps">Treatment that can</span> <span class="hps">be done</span> <span class="hps">is by</span> <span class="hps">blood</span> <span class="hps">transfusion</span>, <span class="hps">bone</span> <span class="hps">marrow</span> <span class="hps">transplant</span>, <span class="hps">anti</span><span class="atn">-</span>sickling <span class="hps">drug delivery</span>, and drug delivery <span class="hps">to trigger</span> <span class="hps">the synthesis of</span> <span class="hps">HbF</span>. <span class="hps">Treatment</span> <span class="hps">still</span> <span class="hps">in the development stage</span> <span class="hps">is to use</span> <span class="hps">stem cells</span>.</span></p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" 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collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gede Agus Suwiryawan I Wayan Putu Sutirta Yasa DAP Rasmika Dewi |
spellingShingle |
Gede Agus Suwiryawan I Wayan Putu Sutirta Yasa DAP Rasmika Dewi ANEMIA SEL SABIT e-Jurnal Medika Udayana Anemia, Sickle cell anemia, Hemoglobin |
author_facet |
Gede Agus Suwiryawan I Wayan Putu Sutirta Yasa DAP Rasmika Dewi |
author_sort |
Gede Agus Suwiryawan |
title |
ANEMIA SEL SABIT |
title_short |
ANEMIA SEL SABIT |
title_full |
ANEMIA SEL SABIT |
title_fullStr |
ANEMIA SEL SABIT |
title_full_unstemmed |
ANEMIA SEL SABIT |
title_sort |
anemia sel sabit |
publisher |
Universitas Udayana |
series |
e-Jurnal Medika Udayana |
issn |
2303-1395 |
publishDate |
2013-09-01 |
topic |
Anemia, Sickle cell anemia, Hemoglobin |
url |
http://ojs.unud.ac.id/index.php/eum/article/view/6292 |
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T<span class="hps">reatment</span> provided <span class="hps">in accordance</span> <span class="hps">with the clinical picture</span> <span class="hps">appears</span>. <span class="hps">Treatment that can</span> <span class="hps">be done</span> <span class="hps">is by</span> <span class="hps">blood</span> <span class="hps">transfusion</span>, <span class="hps">bone</span> <span class="hps">marrow</span> <span class="hps">transplant</span>, <span class="hps">anti</span><span class="atn">-</span>sickling <span class="hps">drug delivery</span>, and drug delivery <span class="hps">to trigger</span> <span class="hps">the synthesis of</span> <span class="hps">HbF</span>. <span class="hps">Treatment</span> <span class="hps">still</span> <span class="hps">in the development stage</span> <span class="hps">is to use</span> <span class="hps">stem cells</span>.</span></p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" 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