TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response

The precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.

Bibliographic Details
Main Authors:	Zhenzhong Ma, Tong Zang, Shari G. Birnbaum, Zilai Wang, Jane E. Johnson, Chun-Li Zhang, Luis F. Parada
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01709-8

id	doaj-6ae59c97782a41d590ffaa6502413f77
record_format	Article
spelling	doaj-6ae59c97782a41d590ffaa6502413f772021-05-11T07:21:30ZengNature Publishing GroupNature Communications2041-17232017-11-018111410.1038/s41467-017-01709-8TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant responseZhenzhong Ma0Tong Zang1Shari G. Birnbaum2Zilai Wang3Jane E. Johnson4Chun-Li Zhang5Luis F. Parada6Department of Developmental Biology & Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical CenterDepartment of Molecular Biology, University of Texas Southwestern Medical CenterDepartment of Psychiatry, University of Texas Southwestern Medical CenterDepartment of Developmental Biology & Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical CenterDepartment of Neuroscience, University of Texas Southwestern Medical CenterDepartment of Molecular Biology, University of Texas Southwestern Medical CenterDepartment of Developmental Biology & Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical CenterThe precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.https://doi.org/10.1038/s41467-017-01709-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhenzhong Ma Tong Zang Shari G. Birnbaum Zilai Wang Jane E. Johnson Chun-Li Zhang Luis F. Parada
spellingShingle	Zhenzhong Ma Tong Zang Shari G. Birnbaum Zilai Wang Jane E. Johnson Chun-Li Zhang Luis F. Parada TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response Nature Communications
author_facet	Zhenzhong Ma Tong Zang Shari G. Birnbaum Zilai Wang Jane E. Johnson Chun-Li Zhang Luis F. Parada
author_sort	Zhenzhong Ma
title	TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
title_short	TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
title_full	TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
title_fullStr	TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
title_full_unstemmed	TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
title_sort	trkb dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-11-01
description	The precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.
url	https://doi.org/10.1038/s41467-017-01709-8
work_keys_str_mv	AT zhenzhongma trkbdependentadulthippocampalprogenitordifferentiationmediatessustainedketamineantidepressantresponse AT tongzang trkbdependentadulthippocampalprogenitordifferentiationmediatessustainedketamineantidepressantresponse AT sharigbirnbaum trkbdependentadulthippocampalprogenitordifferentiationmediatessustainedketamineantidepressantresponse AT zilaiwang trkbdependentadulthippocampalprogenitordifferentiationmediatessustainedketamineantidepressantresponse AT janeejohnson trkbdependentadulthippocampalprogenitordifferentiationmediatessustainedketamineantidepressantresponse AT chunlizhang trkbdependentadulthippocampalprogenitordifferentiationmediatessustainedketamineantidepressantresponse AT luisfparada trkbdependentadulthippocampalprogenitordifferentiationmediatessustainedketamineantidepressantresponse
_version_	1721452351071453184

TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response

Similar Items