TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
The precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.
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2017-11-01
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Online Access: | https://doi.org/10.1038/s41467-017-01709-8 |
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doaj-6ae59c97782a41d590ffaa6502413f772021-05-11T07:21:30ZengNature Publishing GroupNature Communications2041-17232017-11-018111410.1038/s41467-017-01709-8TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant responseZhenzhong Ma0Tong Zang1Shari G. Birnbaum2Zilai Wang3Jane E. Johnson4Chun-Li Zhang5Luis F. Parada6Department of Developmental Biology & Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical CenterDepartment of Molecular Biology, University of Texas Southwestern Medical CenterDepartment of Psychiatry, University of Texas Southwestern Medical CenterDepartment of Developmental Biology & Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical CenterDepartment of Neuroscience, University of Texas Southwestern Medical CenterDepartment of Molecular Biology, University of Texas Southwestern Medical CenterDepartment of Developmental Biology & Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical CenterThe precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.https://doi.org/10.1038/s41467-017-01709-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhenzhong Ma Tong Zang Shari G. Birnbaum Zilai Wang Jane E. Johnson Chun-Li Zhang Luis F. Parada |
spellingShingle |
Zhenzhong Ma Tong Zang Shari G. Birnbaum Zilai Wang Jane E. Johnson Chun-Li Zhang Luis F. Parada TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response Nature Communications |
author_facet |
Zhenzhong Ma Tong Zang Shari G. Birnbaum Zilai Wang Jane E. Johnson Chun-Li Zhang Luis F. Parada |
author_sort |
Zhenzhong Ma |
title |
TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response |
title_short |
TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response |
title_full |
TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response |
title_fullStr |
TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response |
title_full_unstemmed |
TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response |
title_sort |
trkb dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-11-01 |
description |
The precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced. |
url |
https://doi.org/10.1038/s41467-017-01709-8 |
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