Shear-Wave Elastography Variability Analysis and Relation with Kidney Allograft Dysfunction: A Single-Center Study
Shear-wave elastography (SWE) showed the absence or presence of significant differences among stable kidney allograft function and allograft dysfunction. We evaluated the variability of kidney allograft stiffness in relation to allograft dysfunction, respectively, in terms of a correlation of stiffn...
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MDPI AG
2020-01-01
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Series: | Diagnostics |
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Online Access: | https://www.mdpi.com/2075-4418/10/1/41 |
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Article |
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DOAJ |
language |
English |
format |
Article |
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DOAJ |
author |
Sorana D. Bolboacă Florin Ioan Elec Alina Daciana Elec Adriana Milena Muntean Mihai Adrian Socaciu Gheorghita Iacob Răzvan Zaro Alexandra-Ioana Andrieș Ramona Maria Bădulescu Radu Mihai Ignat Mihaela Iancu Radu Ion Badea |
spellingShingle |
Sorana D. Bolboacă Florin Ioan Elec Alina Daciana Elec Adriana Milena Muntean Mihai Adrian Socaciu Gheorghita Iacob Răzvan Zaro Alexandra-Ioana Andrieș Ramona Maria Bădulescu Radu Mihai Ignat Mihaela Iancu Radu Ion Badea Shear-Wave Elastography Variability Analysis and Relation with Kidney Allograft Dysfunction: A Single-Center Study Diagnostics kidney stiffness kidney transplantation shear wave elastography (swe) allograft dysfunction estimated glomerular filtration rate (egfr) ultrasound |
author_facet |
Sorana D. Bolboacă Florin Ioan Elec Alina Daciana Elec Adriana Milena Muntean Mihai Adrian Socaciu Gheorghita Iacob Răzvan Zaro Alexandra-Ioana Andrieș Ramona Maria Bădulescu Radu Mihai Ignat Mihaela Iancu Radu Ion Badea |
author_sort |
Sorana D. Bolboacă |
title |
Shear-Wave Elastography Variability Analysis and Relation with Kidney Allograft Dysfunction: A Single-Center Study |
title_short |
Shear-Wave Elastography Variability Analysis and Relation with Kidney Allograft Dysfunction: A Single-Center Study |
title_full |
Shear-Wave Elastography Variability Analysis and Relation with Kidney Allograft Dysfunction: A Single-Center Study |
title_fullStr |
Shear-Wave Elastography Variability Analysis and Relation with Kidney Allograft Dysfunction: A Single-Center Study |
title_full_unstemmed |
Shear-Wave Elastography Variability Analysis and Relation with Kidney Allograft Dysfunction: A Single-Center Study |
title_sort |
shear-wave elastography variability analysis and relation with kidney allograft dysfunction: a single-center study |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-01-01 |
description |
Shear-wave elastography (SWE) showed the absence or presence of significant differences among stable kidney allograft function and allograft dysfunction. We evaluated the variability of kidney allograft stiffness in relation to allograft dysfunction, respectively, in terms of a correlation of stiffness with patients’ characteristics. A single-center prospective study on patients who had undergone renal transplantation was conducted between October 2017 and November 2018. Patients were clinically classified as having a stable allograft function or allograft dysfunction. SWE examinations performed by the same radiologist with a LOGIQ E9 were evaluated. Ten measurements were done for Young’s modulus (kPa) at the level of allograft cortex and another ten at the level of medulla. Eighty-three SWE examinations from 63 patients, 69 stable allografts, and 14 allografts with dysfunction were included in the analysis. The intra-examinations stiffness showed high variability, with the quantile covariation coefficient ranging from 2.21% to 45.04%. The inter-examinations stiffness showed heterogeneity (from 28.66% to 42.38%). The kidney allograft cortex stiffness showed significantly higher values in cases with dysfunction (median = 28.70 kPa, interquartile range (IQR) = (25.68−31.98) kPa) as compared to those with stable function (median = 20.99 kPa, interquartile range = (16.08−27.68) kPa; <i>p</i>-value = 0.0142). Allograft tissue stiffness (both cortex and medulla) was significantly negatively correlated with body mass index (−0.44, <i>p</i>-value < 0.0001 for allograft cortex and −0.42, <i>p</i>-value = 0.0001 for allograft medulla), and positively correlated with Proteinuria/Creatinuria ratio (0.33, <i>p</i>-value = 0.0021 for allograft cortex and 0.28, <i>p</i>-value = 0.0105 for allograft medulla) but remained statistically significant only in cases with stable function. The cortical tissue stiffness proved significantly higher values for patients with allograft dysfunction as compared to patients with stable function, but to evolve as an additional tool for the evaluation of patients with a kidney transplant and to change the clinical practice, more extensive studies are needed. |
topic |
kidney stiffness kidney transplantation shear wave elastography (swe) allograft dysfunction estimated glomerular filtration rate (egfr) ultrasound |
url |
https://www.mdpi.com/2075-4418/10/1/41 |
work_keys_str_mv |
AT soranadbolboaca shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT florinioanelec shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT alinadacianaelec shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT adrianamilenamuntean shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT mihaiadriansocaciu shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT gheorghitaiacob shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT razvanzaro shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT alexandraioanaandries shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT ramonamariabadulescu shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT radumihaiignat shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT mihaelaiancu shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy AT raduionbadea shearwaveelastographyvariabilityanalysisandrelationwithkidneyallograftdysfunctionasinglecenterstudy |
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1724871519625019392 |
spelling |
doaj-6aebe321d23947cd9c56fa6b18ae50d22020-11-25T02:20:25ZengMDPI AGDiagnostics2075-44182020-01-011014110.3390/diagnostics10010041diagnostics10010041Shear-Wave Elastography Variability Analysis and Relation with Kidney Allograft Dysfunction: A Single-Center StudySorana D. Bolboacă0Florin Ioan Elec1Alina Daciana Elec2Adriana Milena Muntean3Mihai Adrian Socaciu4Gheorghita Iacob5Răzvan Zaro6Alexandra-Ioana Andrieș7Ramona Maria Bădulescu8Radu Mihai Ignat9Mihaela Iancu10Radu Ion Badea11Department of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Str., no. 6, 400349 Cluj-Napoca, RomaniaDepartment of Urology, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Clinicilor Str., no. 4-6, 400006 Cluj-Napoca, RomaniaDepartment of Renal Transplantation, Clinical Institute of Urology and Renal Transplantation, Clinicilor Str., no. 4-6, 400006 Cluj-Napoca, RomaniaDepartment of Renal Transplantation, Clinical Institute of Urology and Renal Transplantation, Clinicilor Str., no. 4-6, 400006 Cluj-Napoca, RomaniaDepartment of Medical Imaging, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Croitorilor Str., no. 19-23, 400162 Cluj-Napoca, RomaniaDepartment of Renal Transplantation, Clinical Institute of Urology and Renal Transplantation, Clinicilor Str., no. 4-6, 400006 Cluj-Napoca, RomaniaDepartment of Medical Imaging, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Croitorilor Str., no. 19-23, 400162 Cluj-Napoca, RomaniaDepartment of Medical Imaging, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Croitorilor Str., no. 19-23, 400162 Cluj-Napoca, RomaniaDepartment of Urology, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Clinicilor Str., no. 4-6, 400006 Cluj-Napoca, RomaniaDepartment of Anatomy, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Clinicilor Str., no. 3-5, 400006 Cluj-Napoca, RomaniaDepartment of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Str., no. 6, 400349 Cluj-Napoca, RomaniaDepartment of Medical Imaging, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Croitorilor Str., no. 19-23, 400162 Cluj-Napoca, RomaniaShear-wave elastography (SWE) showed the absence or presence of significant differences among stable kidney allograft function and allograft dysfunction. We evaluated the variability of kidney allograft stiffness in relation to allograft dysfunction, respectively, in terms of a correlation of stiffness with patients’ characteristics. A single-center prospective study on patients who had undergone renal transplantation was conducted between October 2017 and November 2018. Patients were clinically classified as having a stable allograft function or allograft dysfunction. SWE examinations performed by the same radiologist with a LOGIQ E9 were evaluated. Ten measurements were done for Young’s modulus (kPa) at the level of allograft cortex and another ten at the level of medulla. Eighty-three SWE examinations from 63 patients, 69 stable allografts, and 14 allografts with dysfunction were included in the analysis. The intra-examinations stiffness showed high variability, with the quantile covariation coefficient ranging from 2.21% to 45.04%. The inter-examinations stiffness showed heterogeneity (from 28.66% to 42.38%). The kidney allograft cortex stiffness showed significantly higher values in cases with dysfunction (median = 28.70 kPa, interquartile range (IQR) = (25.68−31.98) kPa) as compared to those with stable function (median = 20.99 kPa, interquartile range = (16.08−27.68) kPa; <i>p</i>-value = 0.0142). Allograft tissue stiffness (both cortex and medulla) was significantly negatively correlated with body mass index (−0.44, <i>p</i>-value < 0.0001 for allograft cortex and −0.42, <i>p</i>-value = 0.0001 for allograft medulla), and positively correlated with Proteinuria/Creatinuria ratio (0.33, <i>p</i>-value = 0.0021 for allograft cortex and 0.28, <i>p</i>-value = 0.0105 for allograft medulla) but remained statistically significant only in cases with stable function. The cortical tissue stiffness proved significantly higher values for patients with allograft dysfunction as compared to patients with stable function, but to evolve as an additional tool for the evaluation of patients with a kidney transplant and to change the clinical practice, more extensive studies are needed.https://www.mdpi.com/2075-4418/10/1/41kidney stiffnesskidney transplantationshear wave elastography (swe)allograft dysfunctionestimated glomerular filtration rate (egfr)ultrasound |