Rise of TRIM8: A Molecule of Duality
The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. In this review, in addition to accumulating recent corroborations that endors...
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doaj-6aef7a0d8f8a4e039fa70786ebe379d22020-12-05T04:20:27ZengElsevierMolecular Therapy: Nucleic Acids2162-25312020-12-0122434444Rise of TRIM8: A Molecule of DualityUtsa Bhaduri0Giuseppe Merla1Division of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (Foggia), Italy; PhD Programme in Molecular Biomedicine, Department of Life Sciences, University of Trieste, Trieste, Italy; European Union’s Horizon 2020 TRIM-NET Innovative Training Network (ITN) of Marie Sklodowska-Curie Actions (MSCA), University of Trieste, Trieste, ItalyDivision of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (Foggia), Italy; Corresponding author: Giuseppe Merla, PhD, Division of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza, viale Cappuccini, 71013 San Giovanni Rotondo, Foggia, Italy.The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. In this review, in addition to accumulating recent corroborations that endorse this dual character of TRIM8, we appraise the game-changing capacity of TRIM8 under stress conditions against the backdrop of cell proliferation, apoptosis, and cancer, and also highlight the duality of TRIM8 in multiple contexts like cellular localization, stress-induced conditions, and E3 ubiquitin ligase activity. Finally, we discuss the emerging role of TRIM8 during bipolar spindle formation and mitotic progression, and its growing sphere of influence across multiple human cancers and pathologies, and suggest TRIM8-linked axes that can be modulated further for anti-cancer therapeutics development.http://www.sciencedirect.com/science/article/pii/S216225312030264XE3 ubiquitin ligasesTRIM familyTRIM8cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Utsa Bhaduri Giuseppe Merla |
spellingShingle |
Utsa Bhaduri Giuseppe Merla Rise of TRIM8: A Molecule of Duality Molecular Therapy: Nucleic Acids E3 ubiquitin ligases TRIM family TRIM8 cancer |
author_facet |
Utsa Bhaduri Giuseppe Merla |
author_sort |
Utsa Bhaduri |
title |
Rise of TRIM8: A Molecule of Duality |
title_short |
Rise of TRIM8: A Molecule of Duality |
title_full |
Rise of TRIM8: A Molecule of Duality |
title_fullStr |
Rise of TRIM8: A Molecule of Duality |
title_full_unstemmed |
Rise of TRIM8: A Molecule of Duality |
title_sort |
rise of trim8: a molecule of duality |
publisher |
Elsevier |
series |
Molecular Therapy: Nucleic Acids |
issn |
2162-2531 |
publishDate |
2020-12-01 |
description |
The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. In this review, in addition to accumulating recent corroborations that endorse this dual character of TRIM8, we appraise the game-changing capacity of TRIM8 under stress conditions against the backdrop of cell proliferation, apoptosis, and cancer, and also highlight the duality of TRIM8 in multiple contexts like cellular localization, stress-induced conditions, and E3 ubiquitin ligase activity. Finally, we discuss the emerging role of TRIM8 during bipolar spindle formation and mitotic progression, and its growing sphere of influence across multiple human cancers and pathologies, and suggest TRIM8-linked axes that can be modulated further for anti-cancer therapeutics development. |
topic |
E3 ubiquitin ligases TRIM family TRIM8 cancer |
url |
http://www.sciencedirect.com/science/article/pii/S216225312030264X |
work_keys_str_mv |
AT utsabhaduri riseoftrim8amoleculeofduality AT giuseppemerla riseoftrim8amoleculeofduality |
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1724399924202700800 |