Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice

Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice

Diverse clustered protocadherins are thought to function in neurite morphogenesis and neuronal connectivity in the brain. Here, we report that the protocadherin alpha (Pcdha) gene cluster regulates neuronal migration during cortical development and cytoskeletal dynamics in primary cortical culture t...

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Bibliographic Details
Main Authors: Li Fan, Yichao Lu, Xiulian Shen, Hong Shao, Lun Suo, Qiang Wu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
protocadherin
cell-adhesion kinase Pyk2
VCD
WAVE complex
cortical neuron migration
cytoskeletal dynamics
Online Access:https://elifesciences.org/articles/35242

Internet

https://elifesciences.org/articles/35242

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