Hydrogel-coated needles prevent puncture site bleeding in arteriovenous fistula and arteriovenous grafts in rats
Introduction: Imperfect hemostasis after arteriovenous fistula (AVF) and arteriovenous graft (AVG) cannulation can cause a hematoma or pseudoaneurysm and leads to poor satisfaction. We hypothesized that a hydrogel-coated needle would effectively and rapidly stop bleeding after vascular cannulation i...
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doaj-6af7f1bf3caf4daeadbb18ac1f8434412021-10-11T04:14:37ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-11-01143112113Hydrogel-coated needles prevent puncture site bleeding in arteriovenous fistula and arteriovenous grafts in ratsYanhua Xu0Zhiju Wang1Shunbo Wei2Peng Sun3Hualong Bai4Jing’an Li5Department of Internal Medicine, First Affiliated Hospital of Zhengzhou University, Henan, China; Key Vascular Physiology and Applied Research Laboratory of Zhengzhou City, Henan, ChinaKey Vascular Physiology and Applied Research Laboratory of Zhengzhou City, Henan, China; Department of Physiology, Medical school of Zhengzhou University, Henan, ChinaDepartment of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, China; Key Vascular Physiology and Applied Research Laboratory of Zhengzhou City, Henan, ChinaDepartment of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, China; Key Vascular Physiology and Applied Research Laboratory of Zhengzhou City, Henan, ChinaDepartment of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, China; Key Vascular Physiology and Applied Research Laboratory of Zhengzhou City, Henan, China; Correspondence to: Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan 450052, China.School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy & Key Laboratory of Materials Processing and Mold Technology (Ministry of Education), Zhengzhou University, Henan, China; Correspondence to: School of Material Science and Engineering, Zhengzhou University, Henan 450001, China.Introduction: Imperfect hemostasis after arteriovenous fistula (AVF) and arteriovenous graft (AVG) cannulation can cause a hematoma or pseudoaneurysm and leads to poor satisfaction. We hypothesized that a hydrogel-coated needle would effectively and rapidly stop bleeding after vascular cannulation in a rat AVF and AVG model. Method: A hydrogel comprised of sodium alginate (SA), hyaluronic acid (HA), and calcium carbonate was coated onto the surface of suture needles using a rotating system. The needles were observed using scanning electron microscopy (SEM) and immunofluorescence. Rat AVF with or without renal failure and AVG were punctured using bare and hydrogel-coated needles. The tissues were examined by histology. Result: The hydrogel was successfully coated onto the surface of 30 G needles and confirmed by SEM. Hydrogel-coated needles rapidly stopped bleeding after AVF and AVG cannulation in rat. Conclusion: In this preliminary animal research, hydrogel-coated needles can stop AVF and AVG puncture-site bleeding; but additional clinical studies are needed to justify whether it is still effective in clinical.http://www.sciencedirect.com/science/article/pii/S0753332221008970HemostasisHydrogelNeedleArteriovenous fistulaArteriovenous graftPuncture |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yanhua Xu Zhiju Wang Shunbo Wei Peng Sun Hualong Bai Jing’an Li |
spellingShingle |
Yanhua Xu Zhiju Wang Shunbo Wei Peng Sun Hualong Bai Jing’an Li Hydrogel-coated needles prevent puncture site bleeding in arteriovenous fistula and arteriovenous grafts in rats Biomedicine & Pharmacotherapy Hemostasis Hydrogel Needle Arteriovenous fistula Arteriovenous graft Puncture |
author_facet |
Yanhua Xu Zhiju Wang Shunbo Wei Peng Sun Hualong Bai Jing’an Li |
author_sort |
Yanhua Xu |
title |
Hydrogel-coated needles prevent puncture site bleeding in arteriovenous fistula and arteriovenous grafts in rats |
title_short |
Hydrogel-coated needles prevent puncture site bleeding in arteriovenous fistula and arteriovenous grafts in rats |
title_full |
Hydrogel-coated needles prevent puncture site bleeding in arteriovenous fistula and arteriovenous grafts in rats |
title_fullStr |
Hydrogel-coated needles prevent puncture site bleeding in arteriovenous fistula and arteriovenous grafts in rats |
title_full_unstemmed |
Hydrogel-coated needles prevent puncture site bleeding in arteriovenous fistula and arteriovenous grafts in rats |
title_sort |
hydrogel-coated needles prevent puncture site bleeding in arteriovenous fistula and arteriovenous grafts in rats |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2021-11-01 |
description |
Introduction: Imperfect hemostasis after arteriovenous fistula (AVF) and arteriovenous graft (AVG) cannulation can cause a hematoma or pseudoaneurysm and leads to poor satisfaction. We hypothesized that a hydrogel-coated needle would effectively and rapidly stop bleeding after vascular cannulation in a rat AVF and AVG model. Method: A hydrogel comprised of sodium alginate (SA), hyaluronic acid (HA), and calcium carbonate was coated onto the surface of suture needles using a rotating system. The needles were observed using scanning electron microscopy (SEM) and immunofluorescence. Rat AVF with or without renal failure and AVG were punctured using bare and hydrogel-coated needles. The tissues were examined by histology. Result: The hydrogel was successfully coated onto the surface of 30 G needles and confirmed by SEM. Hydrogel-coated needles rapidly stopped bleeding after AVF and AVG cannulation in rat. Conclusion: In this preliminary animal research, hydrogel-coated needles can stop AVF and AVG puncture-site bleeding; but additional clinical studies are needed to justify whether it is still effective in clinical. |
topic |
Hemostasis Hydrogel Needle Arteriovenous fistula Arteriovenous graft Puncture |
url |
http://www.sciencedirect.com/science/article/pii/S0753332221008970 |
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