Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods
High frequency oscillations (HFOs) are traditional biomarkers to identify the epileptogenic tissue during presurgical evaluation in pharmacoresistant epileptic patients. Recently, the resection of brain tissue exhibiting coupling between the amplitude of HFOs and the phase of low frequencies demonst...
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doaj-6b1a8ed8cdb042b98640c0e867a701ae2020-11-24T21:37:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-10-011010.3389/fneur.2019.01132467741Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of MethodsMojtaba Bandarabadi0Mojtaba Bandarabadi1Heidemarie Gast2Christian Rummel3Claudio Bassetti4Claudio Bassetti5Antoine Adamantidis6Antoine Adamantidis7Kaspar Schindler8Frederic Zubler9Department of Neurology, Sleep-Wake-Epilepsy Center, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandDepartment of Neurology, Center for Experimental Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandDepartment of Neurology, Sleep-Wake-Epilepsy Center, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandSupport Center for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandDepartment of Neurology, Sleep-Wake-Epilepsy Center, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandDepartment of Neurology, Center for Experimental Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandDepartment of Neurology, Sleep-Wake-Epilepsy Center, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandDepartment of Neurology, Center for Experimental Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandDepartment of Neurology, Sleep-Wake-Epilepsy Center, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandDepartment of Neurology, Sleep-Wake-Epilepsy Center, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandHigh frequency oscillations (HFOs) are traditional biomarkers to identify the epileptogenic tissue during presurgical evaluation in pharmacoresistant epileptic patients. Recently, the resection of brain tissue exhibiting coupling between the amplitude of HFOs and the phase of low frequencies demonstrated a more favorable surgical outcome. Here we compare the predictive value of ictal HFOs and four methods for quantifying the ictal phase-amplitude coupling, namely mean vector length, phase-locked high gamma, phase locking value, and modulation index (MI). We analyzed 32 seizures from 16 patients to identify the channels that exhibit HFOs and phase-locked HFOs during seizures. We compared the resection ratio, defined as the percentage of channels exhibiting coupling located in the resected tissue, with the postsurgical outcome. We found that the MI is the only method to show a significant difference between the resection ratios of patients with good and poor outcomes. We further show that the whole seizure, not only the onset, is critical to assess epileptogenicity using the phase-locked HFOs. We postulate that the superiority of MI stems from its capacity to assess coupling of discrete HFO events and its independence from the HFO power. These results confirm that quantitative analysis of HFOs can boost presurgical evaluation and indicate the paramount importance of algorithm selection for clinical applications.https://www.frontiersin.org/article/10.3389/fneur.2019.01132/fullepileptogenic zonepresurgical evaluationelectroencephalographyhigh frequency oscillationscross-frequency coupling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mojtaba Bandarabadi Mojtaba Bandarabadi Heidemarie Gast Christian Rummel Claudio Bassetti Claudio Bassetti Antoine Adamantidis Antoine Adamantidis Kaspar Schindler Frederic Zubler |
spellingShingle |
Mojtaba Bandarabadi Mojtaba Bandarabadi Heidemarie Gast Christian Rummel Claudio Bassetti Claudio Bassetti Antoine Adamantidis Antoine Adamantidis Kaspar Schindler Frederic Zubler Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods Frontiers in Neurology epileptogenic zone presurgical evaluation electroencephalography high frequency oscillations cross-frequency coupling |
author_facet |
Mojtaba Bandarabadi Mojtaba Bandarabadi Heidemarie Gast Christian Rummel Claudio Bassetti Claudio Bassetti Antoine Adamantidis Antoine Adamantidis Kaspar Schindler Frederic Zubler |
author_sort |
Mojtaba Bandarabadi |
title |
Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods |
title_short |
Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods |
title_full |
Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods |
title_fullStr |
Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods |
title_full_unstemmed |
Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods |
title_sort |
assessing epileptogenicity using phase-locked high frequency oscillations: a systematic comparison of methods |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2019-10-01 |
description |
High frequency oscillations (HFOs) are traditional biomarkers to identify the epileptogenic tissue during presurgical evaluation in pharmacoresistant epileptic patients. Recently, the resection of brain tissue exhibiting coupling between the amplitude of HFOs and the phase of low frequencies demonstrated a more favorable surgical outcome. Here we compare the predictive value of ictal HFOs and four methods for quantifying the ictal phase-amplitude coupling, namely mean vector length, phase-locked high gamma, phase locking value, and modulation index (MI). We analyzed 32 seizures from 16 patients to identify the channels that exhibit HFOs and phase-locked HFOs during seizures. We compared the resection ratio, defined as the percentage of channels exhibiting coupling located in the resected tissue, with the postsurgical outcome. We found that the MI is the only method to show a significant difference between the resection ratios of patients with good and poor outcomes. We further show that the whole seizure, not only the onset, is critical to assess epileptogenicity using the phase-locked HFOs. We postulate that the superiority of MI stems from its capacity to assess coupling of discrete HFO events and its independence from the HFO power. These results confirm that quantitative analysis of HFOs can boost presurgical evaluation and indicate the paramount importance of algorithm selection for clinical applications. |
topic |
epileptogenic zone presurgical evaluation electroencephalography high frequency oscillations cross-frequency coupling |
url |
https://www.frontiersin.org/article/10.3389/fneur.2019.01132/full |
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