Characterizing the Mechanism of Action of an Ancient Antimicrobial, Manuka Honey, against Pseudomonas aeruginosa Using Modern Transcriptomics

Characterizing the Mechanism of Action of an Ancient Antimicrobial, Manuka Honey, against Pseudomonas aeruginosa Using Modern Transcriptomics

The threat of antimicrobial resistance to human health has prompted interest in complex, natural products with antimicrobial activity. Honey has been an effective topical wound treatment throughout history, predominantly due to its broad-spectrum antimicrobial activity. Unlike traditional antibiotic...

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Bibliographic Details
Main Authors: Daniel Bouzo, Nural N. Cokcetin, Liping Li, Giulia Ballerin, Amy L. Bottomley, James Lazenby, Cynthia B. Whitchurch, Ian T. Paulsen, Karl A. Hassan, Elizabeth J. Harry
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mSystems
Subjects:
pseudomonas aeruginosa
rna-seq
antimicrobial activity
honey
manuka honey
mechanism of action
natural antimicrobial products
transcriptomics
Online Access:https://doi.org/10.1128/mSystems.00106-20

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