Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study
Abstract Introduction The main histological features of the nasal mucosa in choanal atresia are distorted cilia, marked increase of mucous submucosal glands associated with marked reduction of goblet cell density, and lymphocytic cellular infiltration. Objective To study th...
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doaj-6b2e18cc2ce04d4fba77e5a2300cfc972020-11-25T03:55:54ZengThieme Revinter Publicações Ltda.International Archives of Otorhinolaryngology1809-97771809-48642017-03-01210327628010.1055/s-0037-1601404Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary StudyEzzeddin Elsheikh0Mohammad Waheed El-Anwar1Hesham Radwan Abdel-aziz2Otorhinolaryngology-Head and Neck Surgery Department, Faculty of Medicine, Zagazig University, EgyptOtorhinolaryngology-Head and Neck Surgery Department, Faculty of Medicine, Zagazig University, EgyptPathology Department, Faculty of Medicine, Zagazig University, EgyptAbstract Introduction The main histological features of the nasal mucosa in choanal atresia are distorted cilia, marked increase of mucous submucosal glands associated with marked reduction of goblet cell density, and lymphocytic cellular infiltration. Objective To study the nasal mucosal changes in cases of choanal atresia after successful repair compared with pre-repair mucosal histological features. Methods Tissue samples were taken from the inferior turbinate of 3 patients (1 bilateral and 2 unilateral) who were successfully operated. Then, the biopsies were subjected to histopathological, histochemical and immunohistochemical studies. After that, the results were compared with pre-repair findings in the choanal atresia side and in the normal side. Results Four biopsies (4 repaired choanal atresia sides) of the mucosa of the inferior turbinate revealed that 1 patient (who had a bilateral choanal atresia repaired), after achieving a patent choana for 8 months, had not completely recovered a normal nasal mucosa. The other 2 patients, after 18 and 23 months of achieving a patent choana, showed normal nasal cavities. Conclusion The main histological features of the nasal mucosa in choanal atresia could be reversed by surgery, making the patients regain their choanal patency, with their mucosae changing back to normal gradually with time.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1601404choanal atresianasal mucosaendoscopes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ezzeddin Elsheikh Mohammad Waheed El-Anwar Hesham Radwan Abdel-aziz |
spellingShingle |
Ezzeddin Elsheikh Mohammad Waheed El-Anwar Hesham Radwan Abdel-aziz Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study International Archives of Otorhinolaryngology choanal atresia nasal mucosa endoscopes |
author_facet |
Ezzeddin Elsheikh Mohammad Waheed El-Anwar Hesham Radwan Abdel-aziz |
author_sort |
Ezzeddin Elsheikh |
title |
Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study |
title_short |
Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study |
title_full |
Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study |
title_fullStr |
Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study |
title_full_unstemmed |
Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study |
title_sort |
impact of successful choanal atresia repair on the nasal mucosa: a preliminary study |
publisher |
Thieme Revinter Publicações Ltda. |
series |
International Archives of Otorhinolaryngology |
issn |
1809-9777 1809-4864 |
publishDate |
2017-03-01 |
description |
Abstract
Introduction The main histological features of the nasal mucosa in choanal atresia are distorted cilia, marked increase of mucous submucosal glands associated with marked reduction of goblet cell density, and lymphocytic cellular infiltration.
Objective To study the nasal mucosal changes in cases of choanal atresia after successful repair compared with pre-repair mucosal histological features.
Methods Tissue samples were taken from the inferior turbinate of 3 patients (1 bilateral and 2 unilateral) who were successfully operated. Then, the biopsies were subjected to histopathological, histochemical and immunohistochemical studies. After that, the results were compared with pre-repair findings in the choanal atresia side and in the normal side.
Results Four biopsies (4 repaired choanal atresia sides) of the mucosa of the inferior turbinate revealed that 1 patient (who had a bilateral choanal atresia repaired), after achieving a patent choana for 8 months, had not completely recovered a normal nasal mucosa. The other 2 patients, after 18 and 23 months of achieving a patent choana, showed normal nasal cavities.
Conclusion The main histological features of the nasal mucosa in choanal atresia could be reversed by surgery, making the patients regain their choanal patency, with their mucosae changing back to normal gradually with time. |
topic |
choanal atresia nasal mucosa endoscopes |
url |
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1601404 |
work_keys_str_mv |
AT ezzeddinelsheikh impactofsuccessfulchoanalatresiarepaironthenasalmucosaapreliminarystudy AT mohammadwaheedelanwar impactofsuccessfulchoanalatresiarepaironthenasalmucosaapreliminarystudy AT heshamradwanabdelaziz impactofsuccessfulchoanalatresiarepaironthenasalmucosaapreliminarystudy |
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