Synthesis and Biological Evaluation of 3-Substituted-indolin-2-one Derivatives Containing Chloropyrrole Moieties

Synthesis and Biological Evaluation of 3-Substituted-indolin-2-one Derivatives Containing Chloropyrrole Moieties

Eighteen novel 3-substituted-indolin-2-ones containing chloropyrroles were synthesized and their biological activities were evaluated. The presence of a chlorine atom on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethyl-amino)ethylcarbamoyl group as a substituent at t...

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Bibliographic Details
Main Authors:	Rong-Hua Zhang, Lin Xiao, Quan-Hai Liu, Zhan-Cheng Li, Nan Ma, Da-Xu Fu, Yun-Zhou Jin
Format:	Article
Language:	English
Published:	MDPI AG 2011-11-01
Series:	Molecules
Subjects:	antitumor activities indolin-2-one chloropyrrole synthesis
Online Access:	http://www.mdpi.com/1420-3049/16/11/9368/

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