Anti-Angiogenic Property of Free Human Oligosaccharides
Angiogenesis, a fundamental process in human physiology and pathology, has attracted considerable attention owing to its potential as a therapeutic strategy. Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are deemed major mediators of angiogenesis. To date, inhibition of the VEGF...
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doaj-6b368eac99ef4565a58a68cba731ff4c2021-06-01T00:45:12ZengMDPI AGBiomolecules2218-273X2021-05-011177577510.3390/biom11060775Anti-Angiogenic Property of Free Human OligosaccharidesBoram Bae0Haeun Kim1Hyerin Park2Young Jun Koh3Sung-Jin Bae4Ki-Tae Ha5Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Gyeongsangnam-do, KoreaDepartment of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Gyeongsangnam-do, KoreaKorean Medical Research Center for Healthy Aging, Pusan National University, Yangsan 50612, Gyeongsangnam-do, KoreaGI Innovation, Inc., A-1116, Tera Tower, Songpa-gu, Seoul 05855, KoreaKorean Medical Research Center for Healthy Aging, Pusan National University, Yangsan 50612, Gyeongsangnam-do, KoreaDepartment of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Gyeongsangnam-do, KoreaAngiogenesis, a fundamental process in human physiology and pathology, has attracted considerable attention owing to its potential as a therapeutic strategy. Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are deemed major mediators of angiogenesis. To date, inhibition of the VEGF-A/VEGFR-2 axis has been an effective strategy employed in the development of anticancer drugs. However, some limitations, such as low efficacy and side effects, need to be addressed. Several drug candidates have been discovered, including small molecule compounds, recombinant proteins, and oligosaccharides. In this review, we focus on human oligosaccharides as modulators of angiogenesis. In particular, sialylated human milk oligosaccharides (HMOs) play a significant role in the inhibition of VEGFR-2-mediated angiogenesis. We discuss the structural features concerning the interaction between sialylated HMOs and VEGFR-2 as a molecular mechanism of anti-angiogenesis modulation and its effectiveness in vivo experiments. In the current state, extensive clinical trials are required to develop a novel VEGFR-2 inhibitor from sialylated HMOs.https://www.mdpi.com/2218-273X/11/6/775human milk oligosaccharidessialyllactoseangiogenesisVEGFR-2inhibitor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Boram Bae Haeun Kim Hyerin Park Young Jun Koh Sung-Jin Bae Ki-Tae Ha |
spellingShingle |
Boram Bae Haeun Kim Hyerin Park Young Jun Koh Sung-Jin Bae Ki-Tae Ha Anti-Angiogenic Property of Free Human Oligosaccharides Biomolecules human milk oligosaccharides sialyllactose angiogenesis VEGFR-2 inhibitor |
author_facet |
Boram Bae Haeun Kim Hyerin Park Young Jun Koh Sung-Jin Bae Ki-Tae Ha |
author_sort |
Boram Bae |
title |
Anti-Angiogenic Property of Free Human Oligosaccharides |
title_short |
Anti-Angiogenic Property of Free Human Oligosaccharides |
title_full |
Anti-Angiogenic Property of Free Human Oligosaccharides |
title_fullStr |
Anti-Angiogenic Property of Free Human Oligosaccharides |
title_full_unstemmed |
Anti-Angiogenic Property of Free Human Oligosaccharides |
title_sort |
anti-angiogenic property of free human oligosaccharides |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2021-05-01 |
description |
Angiogenesis, a fundamental process in human physiology and pathology, has attracted considerable attention owing to its potential as a therapeutic strategy. Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are deemed major mediators of angiogenesis. To date, inhibition of the VEGF-A/VEGFR-2 axis has been an effective strategy employed in the development of anticancer drugs. However, some limitations, such as low efficacy and side effects, need to be addressed. Several drug candidates have been discovered, including small molecule compounds, recombinant proteins, and oligosaccharides. In this review, we focus on human oligosaccharides as modulators of angiogenesis. In particular, sialylated human milk oligosaccharides (HMOs) play a significant role in the inhibition of VEGFR-2-mediated angiogenesis. We discuss the structural features concerning the interaction between sialylated HMOs and VEGFR-2 as a molecular mechanism of anti-angiogenesis modulation and its effectiveness in vivo experiments. In the current state, extensive clinical trials are required to develop a novel VEGFR-2 inhibitor from sialylated HMOs. |
topic |
human milk oligosaccharides sialyllactose angiogenesis VEGFR-2 inhibitor |
url |
https://www.mdpi.com/2218-273X/11/6/775 |
work_keys_str_mv |
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