PARP inhibitors in gastric cancer: beacon of hope

PARP inhibitors in gastric cancer: beacon of hope

Abstract Defects in the DNA damage response (DDR) can lead to genome instability, producing mutations or aberrations that promote the development and progression of cancer. But it also confers such cells vulnerable to cell death when they inhibit DNA damage repair. Poly (ADP-ribose) polymerase (PARP...

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Bibliographic Details
Main Authors: Yali Wang, Kun Zheng, Yongbiao Huang, Hua Xiong, Jinfang Su, Rui Chen, Yanmei Zou
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PARP inhibitor
Gastric cancer
DNA damage response
Cancer treatment
Online Access:https://doi.org/10.1186/s13046-021-02005-6

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