Epstein–Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity
Epstein–Barr virus (EBV) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (LPDs) in immunocompromised patients. EBV, a B-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological t...
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doaj-6b4656cf13c947008dac5f93c4818eb02020-11-24T20:45:53ZengElsevierJapanese Dental Science Review1882-76162017-08-015339510910.1016/j.jdsr.2017.01.002Epstein–Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavityKentaro Kikuchi0Harumi Inoue1Yuji Miyazaki2Fumio Ide3Masaru Kojima4Kaoru Kusama5Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanDivision of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanDivision of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanDivision of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanDepartment of Anatomic and Diagnostic Pathology, Dokkyo Medical University School of Medicine, 880 Oaza-kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, JapanDivision of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanEpstein–Barr virus (EBV) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (LPDs) in immunocompromised patients. EBV, a B-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological types of lymphoid malignancy. Furthermore, EBV is associated with epithelial malignancies such as nasopharyngeal carcinoma (NPC), salivary gland tumor, gastric carcinoma and breast carcinoma. In terms of oral disease, there have been several reports of EBV-related oral squamous cell carcinoma (OSCC) worldwide. However, the role of EBV in tumorigenesis of human oral epithelial or lymphoid tissue is unclear. This review summarizes EBV-related epithelial and non-epithelial tumors or tumor-like lesions of the oral cavity. In addition, we describe EBV latent genes and their expression in normal epithelium, inflamed gingiva, epithelial dysplasia and SCC, as well as considering LPDs (MTX- and age-related) and DLBCLs of the oral cavity.http://www.sciencedirect.com/science/article/pii/S188276161730008XEpstein–Barr virus (EBV)Oral squamous cell carcinoma (OSCC)MTX- and age-related EBV + B-cell LPDActivation-induced cytidine deaminase (AID)Early growth transcription response-1 (Egr-1) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kentaro Kikuchi Harumi Inoue Yuji Miyazaki Fumio Ide Masaru Kojima Kaoru Kusama |
spellingShingle |
Kentaro Kikuchi Harumi Inoue Yuji Miyazaki Fumio Ide Masaru Kojima Kaoru Kusama Epstein–Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity Japanese Dental Science Review Epstein–Barr virus (EBV) Oral squamous cell carcinoma (OSCC) MTX- and age-related EBV + B-cell LPD Activation-induced cytidine deaminase (AID) Early growth transcription response-1 (Egr-1) |
author_facet |
Kentaro Kikuchi Harumi Inoue Yuji Miyazaki Fumio Ide Masaru Kojima Kaoru Kusama |
author_sort |
Kentaro Kikuchi |
title |
Epstein–Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity |
title_short |
Epstein–Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity |
title_full |
Epstein–Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity |
title_fullStr |
Epstein–Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity |
title_full_unstemmed |
Epstein–Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity |
title_sort |
epstein–barr virus (ebv)-associated epithelial and non-epithelial lesions of the oral cavity |
publisher |
Elsevier |
series |
Japanese Dental Science Review |
issn |
1882-7616 |
publishDate |
2017-08-01 |
description |
Epstein–Barr virus (EBV) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (LPDs) in immunocompromised patients. EBV, a B-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological types of lymphoid malignancy. Furthermore, EBV is associated with epithelial malignancies such as nasopharyngeal carcinoma (NPC), salivary gland tumor, gastric carcinoma and breast carcinoma. In terms of oral disease, there have been several reports of EBV-related oral squamous cell carcinoma (OSCC) worldwide. However, the role of EBV in tumorigenesis of human oral epithelial or lymphoid tissue is unclear. This review summarizes EBV-related epithelial and non-epithelial tumors or tumor-like lesions of the oral cavity. In addition, we describe EBV latent genes and their expression in normal epithelium, inflamed gingiva, epithelial dysplasia and SCC, as well as considering LPDs (MTX- and age-related) and DLBCLs of the oral cavity. |
topic |
Epstein–Barr virus (EBV) Oral squamous cell carcinoma (OSCC) MTX- and age-related EBV + B-cell LPD Activation-induced cytidine deaminase (AID) Early growth transcription response-1 (Egr-1) |
url |
http://www.sciencedirect.com/science/article/pii/S188276161730008X |
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