Hyperhomocysteinemia and Vitamin B12 deficiency as a risk factor for ischemic stroke: A case–control study from Northwestern India
BACKGROUND: Vitamin B12 (B12) deficiency, by virtue of causing hyperhomocysteinemia (HHC), may be implicated as an acquired risk factor of ischemic stroke (IS), which is also easily modifiable. There is a scarcity of data from India regarding the prevalence of B12 deficiency in IS patients. OBJECTIV...
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doaj-6b486394be2046daba6b2742477e161d2020-11-25T00:01:37ZengWolters Kluwer Medknow PublicationsIndian Journal of Health Sciences and Biomedical Research KLEU2542-62142542-62222018-01-0111322823310.4103/kleuhsj.kleuhsj_9_18Hyperhomocysteinemia and Vitamin B12 deficiency as a risk factor for ischemic stroke: A case–control study from Northwestern IndiaBanshi Lal KumawatChandra Mohan SharmaMohit J ShahMaulik A PanchalBACKGROUND: Vitamin B12 (B12) deficiency, by virtue of causing hyperhomocysteinemia (HHC), may be implicated as an acquired risk factor of ischemic stroke (IS), which is also easily modifiable. There is a scarcity of data from India regarding the prevalence of B12 deficiency in IS patients. OBJECTIVES: The objective of this study is to explore the relationship between B12 and folate deficiency, HHC, and IS. DESIGN: The study was a case–control study. MATERIALS AND METHODS: Eighty cases of IS were compared with equal number of age- and sex-matched controls. Plasma total homocysteine (tHcy) level, serum B12, and folate levels were analyzed as continuous data (Student's t-test) as well as categorical data (Chi-square test). Odds ratio (OR) for the occurrence of IS was calculated for each variable. Correlation of tHcy with serum B12 and folate was studied using Pearson's coefficient. RESULTS: Mean homocysteine was higher in cases compared to controls (20.49 ± 12.64 vs. 13.09 ± 6.96 μmol/L, P < 0.001, while B12 (282.46 ± 161.52 vs. 480 ± 248.92 pg/ml, P < 0.001) and folate (10.49 ± 6.86 vs. 17.00 ± 5.52 ng/ml, P < 0.001) were lower. Both HHC (OR 4.48, 95% confidence interval: 1.99–10.07, P + 0.0003) and B12 deficiency emerged as significant risk factors for occurrence of IS. Negative correlation of homocysteine with B12 (r = 0.457, P < 0.0001) and folate (r = 0.337, P = 0.0001) was observed. CONCLUSIONS: HHC appears to be an important risk factor for IS in Indian population. B12 deficiency is a major acquired cause for the same while folate deficiency is relatively rare.http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2018;volume=11;issue=3;spage=228;epage=233;aulast=KumawatFolatehyperhomocysteinemiaischemic strokeVitamin B12 deficiency |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Banshi Lal Kumawat Chandra Mohan Sharma Mohit J Shah Maulik A Panchal |
spellingShingle |
Banshi Lal Kumawat Chandra Mohan Sharma Mohit J Shah Maulik A Panchal Hyperhomocysteinemia and Vitamin B12 deficiency as a risk factor for ischemic stroke: A case–control study from Northwestern India Indian Journal of Health Sciences and Biomedical Research KLEU Folate hyperhomocysteinemia ischemic stroke Vitamin B12 deficiency |
author_facet |
Banshi Lal Kumawat Chandra Mohan Sharma Mohit J Shah Maulik A Panchal |
author_sort |
Banshi Lal Kumawat |
title |
Hyperhomocysteinemia and Vitamin B12 deficiency as a risk factor for ischemic stroke: A case–control study from Northwestern India |
title_short |
Hyperhomocysteinemia and Vitamin B12 deficiency as a risk factor for ischemic stroke: A case–control study from Northwestern India |
title_full |
Hyperhomocysteinemia and Vitamin B12 deficiency as a risk factor for ischemic stroke: A case–control study from Northwestern India |
title_fullStr |
Hyperhomocysteinemia and Vitamin B12 deficiency as a risk factor for ischemic stroke: A case–control study from Northwestern India |
title_full_unstemmed |
Hyperhomocysteinemia and Vitamin B12 deficiency as a risk factor for ischemic stroke: A case–control study from Northwestern India |
title_sort |
hyperhomocysteinemia and vitamin b12 deficiency as a risk factor for ischemic stroke: a case–control study from northwestern india |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Health Sciences and Biomedical Research KLEU |
issn |
2542-6214 2542-6222 |
publishDate |
2018-01-01 |
description |
BACKGROUND: Vitamin B12 (B12) deficiency, by virtue of causing hyperhomocysteinemia (HHC), may be implicated as an acquired risk factor of ischemic stroke (IS), which is also easily modifiable. There is a scarcity of data from India regarding the prevalence of B12 deficiency in IS patients.
OBJECTIVES: The objective of this study is to explore the relationship between B12 and folate deficiency, HHC, and IS.
DESIGN: The study was a case–control study.
MATERIALS AND METHODS: Eighty cases of IS were compared with equal number of age- and sex-matched controls. Plasma total homocysteine (tHcy) level, serum B12, and folate levels were analyzed as continuous data (Student's t-test) as well as categorical data (Chi-square test). Odds ratio (OR) for the occurrence of IS was calculated for each variable. Correlation of tHcy with serum B12 and folate was studied using Pearson's coefficient.
RESULTS: Mean homocysteine was higher in cases compared to controls (20.49 ± 12.64 vs. 13.09 ± 6.96 μmol/L, P < 0.001, while B12 (282.46 ± 161.52 vs. 480 ± 248.92 pg/ml, P < 0.001) and folate (10.49 ± 6.86 vs. 17.00 ± 5.52 ng/ml, P < 0.001) were lower. Both HHC (OR 4.48, 95% confidence interval: 1.99–10.07, P + 0.0003) and B12 deficiency emerged as significant risk factors for occurrence of IS. Negative correlation of homocysteine with B12 (r = 0.457, P < 0.0001) and folate (r = 0.337, P = 0.0001) was observed.
CONCLUSIONS: HHC appears to be an important risk factor for IS in Indian population. B12 deficiency is a major acquired cause for the same while folate deficiency is relatively rare. |
topic |
Folate hyperhomocysteinemia ischemic stroke Vitamin B12 deficiency |
url |
http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2018;volume=11;issue=3;spage=228;epage=233;aulast=Kumawat |
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