Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer
Tumor dormancy, a clinically undetectable state of cancer, makes a major contribution to the development of multidrug resistance (MDR), minimum residual disease (MRD), tumor outgrowth, cancer relapse, and metastasis. Despite its high incidence, the whole picture of dormancy-regulated molecular progr...
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doaj-6b4bb8c4baf24f9892ae57f50fe251552020-11-24T21:56:42ZengMDPI AGCancers2072-66942019-08-01118120710.3390/cancers11081207cancers11081207Tumor Cell Dormancy: Threat or Opportunity in the Fight against CancerRana Jahanban-Esfahlan0Khaled Seidi1Masoud H. Manjili2Ali Jahanban-Esfahlan3Tahereh Javaheri4Peyman Zare5Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 9841, IranBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 9841, IranDepartment of Microbiology & Immunology, VCU School of Medicine, Massey Cancer Center, Richmond, VA 23298, USAStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz 9841, IranLudwig Boltzmann Institute for Cancer Research, 1090 Vienna, AustriaFaculty of Medicine, Cardinal Stefan Wyszyński University in Warsaw, 01-938 Warsaw, PolandTumor dormancy, a clinically undetectable state of cancer, makes a major contribution to the development of multidrug resistance (MDR), minimum residual disease (MRD), tumor outgrowth, cancer relapse, and metastasis. Despite its high incidence, the whole picture of dormancy-regulated molecular programs is far from clear. That is, it is unknown when and which dormant cells will resume proliferation causing late relapse, and which will remain asymptomatic and harmless to their hosts. Thus, identification of dormancy-related culprits and understanding their roles can help predict cancer prognosis and may increase the probability of timely therapeutic intervention for the desired outcome. Here, we provide a comprehensive review of the dormancy-dictated molecular mechanisms, including angiogenic switch, immune escape, cancer stem cells, extracellular matrix (ECM) remodeling, metabolic reprogramming, miRNAs, epigenetic modifications, and stress-induced p38 signaling pathways. Further, we analyze the possibility of leveraging these dormancy-related molecular cues to outmaneuver cancer and discuss the implications of such approaches in cancer treatment.https://www.mdpi.com/2072-6694/11/8/1207tumor dormancytumor relapsetumor escapemetastasiscancer therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rana Jahanban-Esfahlan Khaled Seidi Masoud H. Manjili Ali Jahanban-Esfahlan Tahereh Javaheri Peyman Zare |
spellingShingle |
Rana Jahanban-Esfahlan Khaled Seidi Masoud H. Manjili Ali Jahanban-Esfahlan Tahereh Javaheri Peyman Zare Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer Cancers tumor dormancy tumor relapse tumor escape metastasis cancer therapy |
author_facet |
Rana Jahanban-Esfahlan Khaled Seidi Masoud H. Manjili Ali Jahanban-Esfahlan Tahereh Javaheri Peyman Zare |
author_sort |
Rana Jahanban-Esfahlan |
title |
Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer |
title_short |
Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer |
title_full |
Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer |
title_fullStr |
Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer |
title_full_unstemmed |
Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer |
title_sort |
tumor cell dormancy: threat or opportunity in the fight against cancer |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2019-08-01 |
description |
Tumor dormancy, a clinically undetectable state of cancer, makes a major contribution to the development of multidrug resistance (MDR), minimum residual disease (MRD), tumor outgrowth, cancer relapse, and metastasis. Despite its high incidence, the whole picture of dormancy-regulated molecular programs is far from clear. That is, it is unknown when and which dormant cells will resume proliferation causing late relapse, and which will remain asymptomatic and harmless to their hosts. Thus, identification of dormancy-related culprits and understanding their roles can help predict cancer prognosis and may increase the probability of timely therapeutic intervention for the desired outcome. Here, we provide a comprehensive review of the dormancy-dictated molecular mechanisms, including angiogenic switch, immune escape, cancer stem cells, extracellular matrix (ECM) remodeling, metabolic reprogramming, miRNAs, epigenetic modifications, and stress-induced p38 signaling pathways. Further, we analyze the possibility of leveraging these dormancy-related molecular cues to outmaneuver cancer and discuss the implications of such approaches in cancer treatment. |
topic |
tumor dormancy tumor relapse tumor escape metastasis cancer therapy |
url |
https://www.mdpi.com/2072-6694/11/8/1207 |
work_keys_str_mv |
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1725857633832796160 |