Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia
An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years...
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2016-10-01
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doaj-6b4e1e2593be43af9d1242432cc8e6832021-05-04T07:23:56ZengElsevierJournal of Virus Eradication2055-66402016-10-0124227231Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in AsiaB.u.i.V.u. Huy0S.i.r.i.n.y.a. Teeraananchai1L.e.N.g.o.c. Oanh2J.o.h.n. Tucker3N.i.a. Kurniati4R.a.w.i.w.a.n. Hansudewechakul5K.h.a.n.h.H.u.u. Truong6V.o.h.i.t.h. Khol7L.a.m. Van Nguyen8V.i.e.t. Chau Do9P.a.g.a.k.r.o.n.g. Lumbiganon10N.a.n.t.a.k.a. Kongstan11T.o.r.s.a.k. Bunupuradah12T.a.v.i.t.i.y.a. Sudjaritruk13N.a.g.a.l.i.n.g.e.s.w.a.r.a.n. Kumarasamy14N.i.k.K.h.a.i.r.u.l.d.d.i.n.N.i.k. Yusoff15K.a.m.a.r.u.l.A.z.a.h.a.r. Mohd Razali16D.e.w.i.K.u.m.a.r.a. Wati17M.o.y.S.i.e.w. Fong18R.e.v.a.t.h.y. Nallusamy19A.z.a.r. Kariminia20A.n.n.e.t.t.e.H. Sohn21Hanoi Medical University, Hanoi, VietnamHIV-NAT, The Thai Red Cross AIDS Research Centre, Bangkok, ThailandWorldwide Orphans Foundation, Ho Chi Minh City, VietnamNew Hope for Cambodian Children, Phnom Penh, CambodiaCipto Mangunkusumo – Faculty of Medicine Universitas Indonesia, Jakarta, IndonesiaChiangrai Prachanukroh Hospital, Chiang Rai, ThailandChildren's Hospital 1, Ho Chi Minh City, VietnamNational Centre for HIV/AIDS Dermatology and STDs and University of Health Sciences, Phnom Penh, CambodiaNational Hospital of Pediatrics, Hanoi, VietnamChildren's Hospital 2, Ho Chi Minh City, VietnamDepartment of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandDepartment of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandHIV-NAT, The Thai Red Cross AIDS Research Centre, Bangkok, ThailandDepartment of Pediatrics, Faculty of Medicine, Chiang Mai University and Research Institute for Health Sciences, Chiang Mai, ThailandYRGCARE Medical Centre, CART CRS, Chennai, IndiaHospital Raja Perempuan Zainab II, Kelantan, MalaysiaPediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur, MalaysiaSanglah Hospital, Udayana University, Bali, IndonesiaHospital Likas, Kota Kinabalu, MalaysiaPenang Hospital, Penang, MalaysiaThe Kirby Institute, UNSW Australia, Sydney, AustraliaTREAT Asia/amfAR – The Foundation for AIDS Research, Bangkok, Thailand; Corresponding author: Annette H Sohn, TREAT Asia/amfAR, 388 Sukhumvit Road, 2104 Klongtoey, Bangkok, 10110, ThailandAn analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years). Ten-year post-ART survival was 93.4–95.2% across orphan categories. Clinic transfers were higher among single and double orphans than non-orphans (41% vs 11%, P<0.001). On multivariate analysis, children ≥3 years at ART initiation (hazard ratio 1.58 vs <3 years, 95% confidence interval: 1.11–2.24) were more likely to be lost to follow-up. Although post-ART mortality and retention did not differ by orphan status, orphans were at greater risk of starting ART at older ages, and with more severe immunosuppression and poorer growth.http://www.sciencedirect.com/science/article/pii/S205566402030875XorphanpaediatricHIVAsiaantiretroviraltreatment |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
B.u.i.V.u. Huy S.i.r.i.n.y.a. Teeraananchai L.e.N.g.o.c. Oanh J.o.h.n. Tucker N.i.a. Kurniati R.a.w.i.w.a.n. Hansudewechakul K.h.a.n.h.H.u.u. Truong V.o.h.i.t.h. Khol L.a.m. Van Nguyen V.i.e.t. Chau Do P.a.g.a.k.r.o.n.g. Lumbiganon N.a.n.t.a.k.a. Kongstan T.o.r.s.a.k. Bunupuradah T.a.v.i.t.i.y.a. Sudjaritruk N.a.g.a.l.i.n.g.e.s.w.a.r.a.n. Kumarasamy N.i.k.K.h.a.i.r.u.l.d.d.i.n.N.i.k. Yusoff K.a.m.a.r.u.l.A.z.a.h.a.r. Mohd Razali D.e.w.i.K.u.m.a.r.a. Wati M.o.y.S.i.e.w. Fong R.e.v.a.t.h.y. Nallusamy A.z.a.r. Kariminia A.n.n.e.t.t.e.H. Sohn |
spellingShingle |
B.u.i.V.u. Huy S.i.r.i.n.y.a. Teeraananchai L.e.N.g.o.c. Oanh J.o.h.n. Tucker N.i.a. Kurniati R.a.w.i.w.a.n. Hansudewechakul K.h.a.n.h.H.u.u. Truong V.o.h.i.t.h. Khol L.a.m. Van Nguyen V.i.e.t. Chau Do P.a.g.a.k.r.o.n.g. Lumbiganon N.a.n.t.a.k.a. Kongstan T.o.r.s.a.k. Bunupuradah T.a.v.i.t.i.y.a. Sudjaritruk N.a.g.a.l.i.n.g.e.s.w.a.r.a.n. Kumarasamy N.i.k.K.h.a.i.r.u.l.d.d.i.n.N.i.k. Yusoff K.a.m.a.r.u.l.A.z.a.h.a.r. Mohd Razali D.e.w.i.K.u.m.a.r.a. Wati M.o.y.S.i.e.w. Fong R.e.v.a.t.h.y. Nallusamy A.z.a.r. Kariminia A.n.n.e.t.t.e.H. Sohn Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia Journal of Virus Eradication orphan paediatric HIV Asia antiretroviral treatment |
author_facet |
B.u.i.V.u. Huy S.i.r.i.n.y.a. Teeraananchai L.e.N.g.o.c. Oanh J.o.h.n. Tucker N.i.a. Kurniati R.a.w.i.w.a.n. Hansudewechakul K.h.a.n.h.H.u.u. Truong V.o.h.i.t.h. Khol L.a.m. Van Nguyen V.i.e.t. Chau Do P.a.g.a.k.r.o.n.g. Lumbiganon N.a.n.t.a.k.a. Kongstan T.o.r.s.a.k. Bunupuradah T.a.v.i.t.i.y.a. Sudjaritruk N.a.g.a.l.i.n.g.e.s.w.a.r.a.n. Kumarasamy N.i.k.K.h.a.i.r.u.l.d.d.i.n.N.i.k. Yusoff K.a.m.a.r.u.l.A.z.a.h.a.r. Mohd Razali D.e.w.i.K.u.m.a.r.a. Wati M.o.y.S.i.e.w. Fong R.e.v.a.t.h.y. Nallusamy A.z.a.r. Kariminia A.n.n.e.t.t.e.H. Sohn |
author_sort |
B.u.i.V.u. Huy |
title |
Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia |
title_short |
Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia |
title_full |
Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia |
title_fullStr |
Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia |
title_full_unstemmed |
Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia |
title_sort |
impact of orphan status on hiv treatment outcomes and retention in care of children and adolescents in asia |
publisher |
Elsevier |
series |
Journal of Virus Eradication |
issn |
2055-6640 |
publishDate |
2016-10-01 |
description |
An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years). Ten-year post-ART survival was 93.4–95.2% across orphan categories. Clinic transfers were higher among single and double orphans than non-orphans (41% vs 11%, P<0.001). On multivariate analysis, children ≥3 years at ART initiation (hazard ratio 1.58 vs <3 years, 95% confidence interval: 1.11–2.24) were more likely to be lost to follow-up. Although post-ART mortality and retention did not differ by orphan status, orphans were at greater risk of starting ART at older ages, and with more severe immunosuppression and poorer growth. |
topic |
orphan paediatric HIV Asia antiretroviral treatment |
url |
http://www.sciencedirect.com/science/article/pii/S205566402030875X |
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