Association of FMR1 genotypes with in vitro fertilization (IVF) outcomes based on ethnicity/race.
The FMR1 gene, mapping to an area of the X chromosome closely associated with autoimmunity also affects ovarian reserve, with specific genotypes associated with distinct ovarian aging patterns. They, therefore, could also be associated with differences of in vitro fertilization (IVF) outcomes, repor...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3078144?pdf=render |
id |
doaj-6b4e22cd4762495786851a190cbdc757 |
---|---|
record_format |
Article |
spelling |
doaj-6b4e22cd4762495786851a190cbdc7572020-11-24T21:20:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0164e1878110.1371/journal.pone.0018781Association of FMR1 genotypes with in vitro fertilization (IVF) outcomes based on ethnicity/race.Norbert GleicherAndrea WeghoferIrene H LeeDavid H BaradThe FMR1 gene, mapping to an area of the X chromosome closely associated with autoimmunity also affects ovarian reserve, with specific genotypes associated with distinct ovarian aging patterns. They, therefore, could also be associated with differences of in vitro fertilization (IVF) outcomes, reported between races/ethnicities. We analyzed 339 consecutive IVF patients, 232 Caucasian, 59 African and 48 Asian, for FMR1 genotypes, and tested by multiple logistic regressions for associations between race/ethnicity, FMR1 genotype, autoimmunity and pregnancy chances with IVF. FMR1 genotypes were predictive of pregnancy (P = 0.046), het-norm/low most significantly and with decreasing chance in comparison to norm genotypes (OR 0.44; 95% CI 0.23-0.85; P = 0.014). Race/ethnicity was, overall, independently associated (P = 0.03), African demonstrating decreased odds in comparison to Caucasian (OR 0.33. 95%CI 0.13-0.79; P = 0.014). Autoimmunity did not differ but interaction of autoimmunity with FMR1 genotype almost reached significance (P = 0.07). Logistic regression with race/ethnicity and interaction between FMR1 genotype and autoimmunity in the model, demonstrated 2.5-times the odds of being associated with autoimmune positivity (OR 2.5, 1.34-4.55; P = 0.004). FMR1 genotypes offer a possible explanation for differences in IVF outcomes between races/ethnicities.http://europepmc.org/articles/PMC3078144?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Norbert Gleicher Andrea Weghofer Irene H Lee David H Barad |
spellingShingle |
Norbert Gleicher Andrea Weghofer Irene H Lee David H Barad Association of FMR1 genotypes with in vitro fertilization (IVF) outcomes based on ethnicity/race. PLoS ONE |
author_facet |
Norbert Gleicher Andrea Weghofer Irene H Lee David H Barad |
author_sort |
Norbert Gleicher |
title |
Association of FMR1 genotypes with in vitro fertilization (IVF) outcomes based on ethnicity/race. |
title_short |
Association of FMR1 genotypes with in vitro fertilization (IVF) outcomes based on ethnicity/race. |
title_full |
Association of FMR1 genotypes with in vitro fertilization (IVF) outcomes based on ethnicity/race. |
title_fullStr |
Association of FMR1 genotypes with in vitro fertilization (IVF) outcomes based on ethnicity/race. |
title_full_unstemmed |
Association of FMR1 genotypes with in vitro fertilization (IVF) outcomes based on ethnicity/race. |
title_sort |
association of fmr1 genotypes with in vitro fertilization (ivf) outcomes based on ethnicity/race. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2011-01-01 |
description |
The FMR1 gene, mapping to an area of the X chromosome closely associated with autoimmunity also affects ovarian reserve, with specific genotypes associated with distinct ovarian aging patterns. They, therefore, could also be associated with differences of in vitro fertilization (IVF) outcomes, reported between races/ethnicities. We analyzed 339 consecutive IVF patients, 232 Caucasian, 59 African and 48 Asian, for FMR1 genotypes, and tested by multiple logistic regressions for associations between race/ethnicity, FMR1 genotype, autoimmunity and pregnancy chances with IVF. FMR1 genotypes were predictive of pregnancy (P = 0.046), het-norm/low most significantly and with decreasing chance in comparison to norm genotypes (OR 0.44; 95% CI 0.23-0.85; P = 0.014). Race/ethnicity was, overall, independently associated (P = 0.03), African demonstrating decreased odds in comparison to Caucasian (OR 0.33. 95%CI 0.13-0.79; P = 0.014). Autoimmunity did not differ but interaction of autoimmunity with FMR1 genotype almost reached significance (P = 0.07). Logistic regression with race/ethnicity and interaction between FMR1 genotype and autoimmunity in the model, demonstrated 2.5-times the odds of being associated with autoimmune positivity (OR 2.5, 1.34-4.55; P = 0.004). FMR1 genotypes offer a possible explanation for differences in IVF outcomes between races/ethnicities. |
url |
http://europepmc.org/articles/PMC3078144?pdf=render |
work_keys_str_mv |
AT norbertgleicher associationoffmr1genotypeswithinvitrofertilizationivfoutcomesbasedonethnicityrace AT andreaweghofer associationoffmr1genotypeswithinvitrofertilizationivfoutcomesbasedonethnicityrace AT irenehlee associationoffmr1genotypeswithinvitrofertilizationivfoutcomesbasedonethnicityrace AT davidhbarad associationoffmr1genotypeswithinvitrofertilizationivfoutcomesbasedonethnicityrace |
_version_ |
1726003393315471360 |