Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS)....
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Format: | Article |
Language: | English |
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MDPI AG
2019-11-01
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Series: | Journal of Clinical Medicine |
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Online Access: | https://www.mdpi.com/2077-0383/8/11/2013 |
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DOAJ |
language |
English |
format |
Article |
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DOAJ |
author |
Lorenzo Cavagna Ernesto Trallero-Araguás Federica Meloni Ilaria Cavazzana Jorge Rojas-Serrano Eugen Feist Giovanni Zanframundo Valentina Morandi Alain Meyer Jose Antonio Pereira da Silva Carlo Jorge Matos Costa Oyvind Molberg Helena Andersson Veronica Codullo Marta Mosca Simone Barsotti Rossella Neri Carlo Scirè Marcello Govoni Federica Furini Francisco Javier Lopez-Longo Julia Martinez-Barrio Udo Schneider Hanns-Martin Lorenz Andrea Doria Anna Ghirardello Norberto Ortego-Centeno Marco Confalonieri Paola Tomietto Nicolò Pipitone Ana Belen Rodriguez Cambron María Ángeles Blázquez Cañamero Reinhard Edmund Voll Sarah Wendel Salvatore Scarpato Francois Maurier Massimiliano Limonta Paolo Colombelli Margherita Giannini Bernard Geny Eugenio Arrigoni Elena Bravi Paola Migliorini Alessandro Mathieu Matteo Piga Ulrich Drott Christiane Delbrueck Jutta Bauhammer Giovanni Cagnotto Carlo Vancheri Gianluca Sambataro Ellen De Langhe Pier Paolo Sainaghi Cristina Monti Francesca Gigli Berzolari Mariaeva Romano Francesco Bonella Christof Specker Andreas Schwarting Ignacio Villa Blanco Carlo Selmi Angela Ceribelli Laura Nuno Antonio Mera-Varela Nair Perez Gomez Enrico Fusaro Simone Parisi Luigi Sinigaglia Nicoletta Del Papa Maurizio Benucci Marco Amedeo Cimmino Valeria Riccieri Fabrizio Conti Gian Domenico Sebastiani Annamaria Iuliano Giacomo Emmi Daniele Cammelli Marco Sebastiani Andreina Manfredi Javier Bachiller-Corral Walter Alberto Sifuentes Giraldo Giuseppe Paolazzi Lesley Ann Saketkoo Roberto Giorgi Fausto Salaffi Jose Cifrian Roberto Caporali Francesco Locatelli Enrico Marchioni Alberto Pesci Giulia Dei Maria Rosa Pozzi Lomater Claudia Jorg Distler Johannes Knitza George Schett Florenzo Iannone Marco Fornaro Franco Franceschini Luca Quartuccio Roberto Gerli Elena Bartoloni Silvia Bellando Randone Giuseppe Zampogna Montserrat I. Gonzalez Perez Mayra Mejia Esther Vicente Konstantinos Triantafyllias Raquel Lopez-Mejias Marco Matucci-Cerinic Albert Selva-O’Callaghan Santos Castañeda Carlomaurizio Montecucco Miguel Angel Gonzalez-Gay |
spellingShingle |
Lorenzo Cavagna Ernesto Trallero-Araguás Federica Meloni Ilaria Cavazzana Jorge Rojas-Serrano Eugen Feist Giovanni Zanframundo Valentina Morandi Alain Meyer Jose Antonio Pereira da Silva Carlo Jorge Matos Costa Oyvind Molberg Helena Andersson Veronica Codullo Marta Mosca Simone Barsotti Rossella Neri Carlo Scirè Marcello Govoni Federica Furini Francisco Javier Lopez-Longo Julia Martinez-Barrio Udo Schneider Hanns-Martin Lorenz Andrea Doria Anna Ghirardello Norberto Ortego-Centeno Marco Confalonieri Paola Tomietto Nicolò Pipitone Ana Belen Rodriguez Cambron María Ángeles Blázquez Cañamero Reinhard Edmund Voll Sarah Wendel Salvatore Scarpato Francois Maurier Massimiliano Limonta Paolo Colombelli Margherita Giannini Bernard Geny Eugenio Arrigoni Elena Bravi Paola Migliorini Alessandro Mathieu Matteo Piga Ulrich Drott Christiane Delbrueck Jutta Bauhammer Giovanni Cagnotto Carlo Vancheri Gianluca Sambataro Ellen De Langhe Pier Paolo Sainaghi Cristina Monti Francesca Gigli Berzolari Mariaeva Romano Francesco Bonella Christof Specker Andreas Schwarting Ignacio Villa Blanco Carlo Selmi Angela Ceribelli Laura Nuno Antonio Mera-Varela Nair Perez Gomez Enrico Fusaro Simone Parisi Luigi Sinigaglia Nicoletta Del Papa Maurizio Benucci Marco Amedeo Cimmino Valeria Riccieri Fabrizio Conti Gian Domenico Sebastiani Annamaria Iuliano Giacomo Emmi Daniele Cammelli Marco Sebastiani Andreina Manfredi Javier Bachiller-Corral Walter Alberto Sifuentes Giraldo Giuseppe Paolazzi Lesley Ann Saketkoo Roberto Giorgi Fausto Salaffi Jose Cifrian Roberto Caporali Francesco Locatelli Enrico Marchioni Alberto Pesci Giulia Dei Maria Rosa Pozzi Lomater Claudia Jorg Distler Johannes Knitza George Schett Florenzo Iannone Marco Fornaro Franco Franceschini Luca Quartuccio Roberto Gerli Elena Bartoloni Silvia Bellando Randone Giuseppe Zampogna Montserrat I. Gonzalez Perez Mayra Mejia Esther Vicente Konstantinos Triantafyllias Raquel Lopez-Mejias Marco Matucci-Cerinic Albert Selva-O’Callaghan Santos Castañeda Carlomaurizio Montecucco Miguel Angel Gonzalez-Gay Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course Journal of Clinical Medicine antisynthetase syndrome antisynthetase antibodies arthritis myositis interstitial lung disease |
author_facet |
Lorenzo Cavagna Ernesto Trallero-Araguás Federica Meloni Ilaria Cavazzana Jorge Rojas-Serrano Eugen Feist Giovanni Zanframundo Valentina Morandi Alain Meyer Jose Antonio Pereira da Silva Carlo Jorge Matos Costa Oyvind Molberg Helena Andersson Veronica Codullo Marta Mosca Simone Barsotti Rossella Neri Carlo Scirè Marcello Govoni Federica Furini Francisco Javier Lopez-Longo Julia Martinez-Barrio Udo Schneider Hanns-Martin Lorenz Andrea Doria Anna Ghirardello Norberto Ortego-Centeno Marco Confalonieri Paola Tomietto Nicolò Pipitone Ana Belen Rodriguez Cambron María Ángeles Blázquez Cañamero Reinhard Edmund Voll Sarah Wendel Salvatore Scarpato Francois Maurier Massimiliano Limonta Paolo Colombelli Margherita Giannini Bernard Geny Eugenio Arrigoni Elena Bravi Paola Migliorini Alessandro Mathieu Matteo Piga Ulrich Drott Christiane Delbrueck Jutta Bauhammer Giovanni Cagnotto Carlo Vancheri Gianluca Sambataro Ellen De Langhe Pier Paolo Sainaghi Cristina Monti Francesca Gigli Berzolari Mariaeva Romano Francesco Bonella Christof Specker Andreas Schwarting Ignacio Villa Blanco Carlo Selmi Angela Ceribelli Laura Nuno Antonio Mera-Varela Nair Perez Gomez Enrico Fusaro Simone Parisi Luigi Sinigaglia Nicoletta Del Papa Maurizio Benucci Marco Amedeo Cimmino Valeria Riccieri Fabrizio Conti Gian Domenico Sebastiani Annamaria Iuliano Giacomo Emmi Daniele Cammelli Marco Sebastiani Andreina Manfredi Javier Bachiller-Corral Walter Alberto Sifuentes Giraldo Giuseppe Paolazzi Lesley Ann Saketkoo Roberto Giorgi Fausto Salaffi Jose Cifrian Roberto Caporali Francesco Locatelli Enrico Marchioni Alberto Pesci Giulia Dei Maria Rosa Pozzi Lomater Claudia Jorg Distler Johannes Knitza George Schett Florenzo Iannone Marco Fornaro Franco Franceschini Luca Quartuccio Roberto Gerli Elena Bartoloni Silvia Bellando Randone Giuseppe Zampogna Montserrat I. Gonzalez Perez Mayra Mejia Esther Vicente Konstantinos Triantafyllias Raquel Lopez-Mejias Marco Matucci-Cerinic Albert Selva-O’Callaghan Santos Castañeda Carlomaurizio Montecucco Miguel Angel Gonzalez-Gay |
author_sort |
Lorenzo Cavagna |
title |
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title_short |
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title_full |
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title_fullStr |
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title_full_unstemmed |
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title_sort |
influence of antisynthetase antibodies specificities on antisynthetase syndrome clinical spectrum time course |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-11-01 |
description |
Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group’s cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The “ex-novo” occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies’ positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition. |
topic |
antisynthetase syndrome antisynthetase antibodies arthritis myositis interstitial lung disease |
url |
https://www.mdpi.com/2077-0383/8/11/2013 |
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doaj-6b54673943a84b0b82c256cbe88c7fb92020-11-25T01:25:02ZengMDPI AGJournal of Clinical Medicine2077-03832019-11-01811201310.3390/jcm8112013jcm8112013Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time CourseLorenzo Cavagna0Ernesto Trallero-Araguás1Federica Meloni2Ilaria Cavazzana3Jorge Rojas-Serrano4Eugen Feist5Giovanni Zanframundo6Valentina Morandi7Alain Meyer8Jose Antonio Pereira da Silva9Carlo Jorge Matos Costa10Oyvind Molberg11Helena Andersson12Veronica Codullo13Marta Mosca14Simone Barsotti15Rossella Neri16Carlo Scirè17Marcello Govoni18Federica Furini19Francisco Javier Lopez-Longo20Julia Martinez-Barrio21Udo Schneider22Hanns-Martin Lorenz23Andrea Doria24Anna Ghirardello25Norberto Ortego-Centeno26Marco Confalonieri27Paola Tomietto28Nicolò Pipitone29Ana Belen Rodriguez Cambron30María Ángeles Blázquez Cañamero31Reinhard Edmund Voll32Sarah Wendel33Salvatore Scarpato34Francois Maurier35Massimiliano Limonta36Paolo Colombelli37Margherita Giannini38Bernard Geny39Eugenio Arrigoni40Elena Bravi41Paola Migliorini42Alessandro Mathieu43Matteo Piga44Ulrich Drott45Christiane Delbrueck46Jutta Bauhammer47Giovanni Cagnotto48Carlo Vancheri49Gianluca Sambataro50Ellen De Langhe51Pier Paolo Sainaghi52Cristina Monti53Francesca Gigli Berzolari54Mariaeva Romano55Francesco Bonella56Christof Specker57Andreas Schwarting58Ignacio Villa Blanco59Carlo Selmi60Angela Ceribelli61Laura Nuno62Antonio Mera-Varela63Nair Perez Gomez64Enrico Fusaro65Simone Parisi66Luigi Sinigaglia67Nicoletta Del Papa68Maurizio Benucci69Marco Amedeo Cimmino70Valeria Riccieri71Fabrizio Conti72Gian Domenico Sebastiani73Annamaria Iuliano74Giacomo Emmi75Daniele Cammelli76Marco Sebastiani77Andreina Manfredi78Javier Bachiller-Corral79Walter Alberto Sifuentes Giraldo80Giuseppe Paolazzi81Lesley Ann Saketkoo82Roberto Giorgi83Fausto Salaffi84Jose Cifrian85Roberto Caporali86Francesco Locatelli87Enrico Marchioni88Alberto Pesci89Giulia Dei90Maria Rosa Pozzi91Lomater Claudia92Jorg Distler93Johannes Knitza94George Schett95Florenzo Iannone96Marco Fornaro97Franco Franceschini98Luca Quartuccio99Roberto Gerli100Elena Bartoloni101Silvia Bellando Randone102Giuseppe Zampogna103Montserrat I. Gonzalez Perez104Mayra Mejia105Esther Vicente106Konstantinos Triantafyllias107Raquel Lopez-Mejias108Marco Matucci-Cerinic109Albert Selva-O’Callaghan110Santos Castañeda111Carlomaurizio Montecucco112Miguel Angel Gonzalez-Gay113Department of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, ItalyDepartment of Internal Medicine, Vall d’Hebron General Hospital, Universitat Autonoma de Barcelona, GEAS group, 08035 Barcelona, SpainDepartment of Pneumology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN Lung, 27100 Pavia, ItalyDepartment of Rheumatology, University and ASST Spedali Civili—Brescia and ERN ReCONNET, 25123 Brescia, ItalyInterstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, 14080 Mexico City, MexicoDepartment of Rheumatology, Charité—Universitätsmedizin Berlin, 10117 Berlin, GermanyDepartment of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, ItalyDepartment of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, ItalyDepartment of Rheumatology, Hôpitaux Universitaires de Strasbourg and ERN ReCONNET, 67000 Strasbourg, FranceDepartment of Rheumatology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, PortugalDepartment of Rheumatology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, PortugalDepartment of Rheumatology, Oslo University Hospital, 0372 Oslo, NorwayDepartment of Rheumatology, Oslo University Hospital, 0372 Oslo, NorwayDepartment of Rheumatology, Cochin Hospital, 75014 Paris, FranceDepartment of Rheumatology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, ItalyDepartment of Rheumatology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, ItalyDepartment of Rheumatology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, ItalyDepartment of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, 44124 Ferrara, ItalyDepartment of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, 44124 Ferrara, ItalyDepartment of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, 44124 Ferrara, ItalyDepartment of Rheumatology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainDepartment of Rheumatology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainDepartment of Rheumatology, Charité—Universitätsmedizin Berlin, 10117 Berlin, GermanyDepartment of Rheumatology, University of Heidelberg, 69117 Heidelberg, GermanyDepartment of Rheumatology, University of Padua and ERN ReCONNET, 35122 Padova, ItalyDepartment of Rheumatology, University of Padua and ERN ReCONNET, 35122 Padova, ItalyDepartment of Rheumatology, Hospital Universitario San Cecilio, 18016 Granada, SpainDepartment of Pneumology, University Hospital of Cattinara, 34149 Trieste, ItalyDepartment of Rheumatology, University Hospital of Cattinara, 34149 Trieste, ItalyDepartment of Rheumatology, S. Maria Hospital—IRCCS, 42123 Reggio Emilia, ItalyDepartment of Rheumatology, Severo Ochoa Hospital, 28911 Madrid, SpainDepartment of Rheumatology, Severo Ochoa Hospital, 28911 Madrid, SpainDepartment of Rheumatology and Clinical Immunology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79110 Freiburg, GermanyDepartment of Rheumatology and Clinical Immunology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79110 Freiburg, GermanyDepartment of Rheumatology, Ospedale “ Scarlato” Scafati, 84018 Scafati, ItalyDepartment of Rheumatology, HP Metz, Hopital Belle-Ile, 57000 Metz, FranceDepartment of Rheumatology, ASST Papa Giovanni XXIII, 24127 Bergamo, ItalyDepartment of Rheumatology, Ospedale di Treviglio, 24047 Treviglio, ItalyService de Physiologie des Explorations Fonctionnelles, NHC Strasbourg, Université de Strasbourg, 67000 Strasbourg, FranceService de Physiologie des Explorations Fonctionnelles, NHC Strasbourg, Université de Strasbourg, 67000 Strasbourg, FranceDepartment of Rheumatology, Ospedale Guglielmo da Saliceto, 29121 Piacenza, ItalyDepartment of Rheumatology, Ospedale Guglielmo da Saliceto, 29121 Piacenza, ItalyDepartment of Immunology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, ItalyDepartment of Rheumatology, University Clinic and AOU of Cagliari, 09100 Cagliari, ItalyDepartment of Rheumatology, University Clinic and AOU of Cagliari, 09100 Cagliari, ItalyDepartment of Rheumatology, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, GermanyDepartment of Rheumatology, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, GermanyDepartment of Rheumatology, ACURA Centre for Rheumatic Diseases, 76530 Baden-Baden, GermanyDepartment of Rheumatology, Skane University Hospital, 22242 Lund, SwedenDepartment of Pneumology, AOU Catania, 95100 Catania, ItalyDepartment of Pneumology, AOU Catania, 95100 Catania, ItalyDepartment of Rheumatology, University Hospitals, 3000 Leuven, BelgiumDepartment of Rheumatology at CAAD, DiMet, University of Eastern Piedmont (UPO) and AOU “Maggiore della Carità”, 28100 Novara, ItalyDepartment of Public Health, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, 27100 Pavia, ItalyDepartment of Public Health, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, 27100 Pavia, ItalyDepartment of Rheumatology, Niguarda Hospital, 20162 Milan, ItalyDepartment of Pneumology, Ruhrlandklinik, University of Duisburg-Essen and ERN Lung, 45239 Essen, GermanyDepartment of Rheumatology, Ruhrlandklinik, University of Duisburg-Essen, 45239 Essen, GermanyDepartment of Rheumatology, Johannes Gutenberg-University, 55122 Mainz, GermanyDepartment of Rheumatology, Sierrallana Hospital, 39300 Torrelavega, SpainDepartment of Rheumatology, Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Rheumatology, Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Rheumatology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Rheumatology, Hospital Clínico Universitario de Santiago de Compostela, 15702 Santiago de Compostela, SpainDepartment of Rheumatology, Hospital Clínico Universitario de Santiago de Compostela, 15702 Santiago de Compostela, SpainDepartment of Rheumatology, Città della Salute e della Scienza, 10126 Turin, ItalyDepartment of Rheumatology, Città della Salute e della Scienza, 10126 Turin, ItalyDepartment of Rheumatology, Hospital G. Pini—CTO, 20122 Milan, ItalyDepartment of Rheumatology, Hospital G. Pini—CTO, 20122 Milan, ItalyDepartment of Rheumatology, Azienda Ospedaliera San Giovanni di Dio, 50143 Firenze, ItalyDepartment of Rheumatology, University of Genova 16126 Genova, ItalyDepartment of Rheumatology, University La Sapienza and Policlinico Umberto I, 00161 Rome, ItalyDepartment of Rheumatology, University La Sapienza and Policlinico Umberto I, 00161 Rome, ItalyDepartment of Rheumatology, Ospedale San Camillo, 00152 Rome, ItalyDepartment of Rheumatology, Ospedale San Camillo, 00152 Rome, ItalyDepartment of Internal Medicine, AOU Careggi, 50134 Firenze, ItalyDepartment of Immunology, AOU Careggi, 50134 Firenze, ItalyDepartment of Rheumatology, Azienda Ospedaliera Universitaria di Modena, 41125 Modena, ItalyDepartment of Rheumatology, Azienda Ospedaliera Universitaria di Modena, 41125 Modena, ItalyDepartment of Rheumatology, Hospital Universitario Ramon y Cajal, 28034 Madrid, SpainDepartment of Rheumatology, Hospital Universitario Ramon y Cajal, 28034 Madrid, SpainDepartment of Rheumatology, Ospedale Santa Chiara, 38122 Trento, ItalyUniversity Medical Center- Comprehensive Pulmonary Hypertension Center & Interstitial Lung Disease Clinic Programs, Louisiana State University and Tulane University Schools of Medicine, Pulmonary Division New Orleans, New Orleans, LA 1542, USADepartment of Rheumatology, ASL Cuneo 2, 12051 Alba, ItalyDepartment of Rheumatology, Polytechnic University of Marche, C. Urbani Hospital, 60035 Jesi, ItalyDepartment of Pneumology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, SpainDepartment of Clinical Sciences and Community Health, University of Milan and Gaetano Pini Hospital, 20122 Milan, ItalyDepartment of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, ItalyDepartment of Neurology, IRCCS Mondino Foundation, 27100 Pavia, ItalyDepartment of Pneumology, Univerity of Milano Bicocca, San Gerardo Hospital, 20900 Monza, ItalyDepartment of Pneumology, Univerity of Milano Bicocca, San Gerardo Hospital, 20900 Monza, ItalyDepartment of Pneumology, Univerity of Milano Bicocca, San Gerardo Hospital, 20900 Monza, ItalyDepartment of Rheumatology, Mauriziano Hospital, 10126 Turin, ItalyDepartment of Internal Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyDepartment of Internal Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyDepartment of Internal Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyRheumatology Unit—DETO, University of Bari, 70121 Bari, ItalyRheumatology Unit—DETO, University of Bari, 70121 Bari, ItalyDepartment of Rheumatology, University and ASST Spedali Civili—Brescia and ERN ReCONNET, 25123 Brescia, ItalyClinic of Rheumatology, Department of Medicine, Santa Maria della Misericordia Hospital and University of Udine, 33100 Udine, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06129 Perugia, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06129 Perugia, ItalyDepartment of Rheumatology, AOU Careggi, 50134 Firenze, ItalyDepartment of Rheumatology, AO Brunico, 39031 Bruneck, ItalyInterstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, 14080 Mexico City, MexicoInterstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, 14080 Mexico City, MexicoDepartment of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, 28006 Madrid, SpainDepartment of Rheumatology, ACURA Center for Rheumatic Diseases, 55543 Bad Kreuznach, GermanyDepartment of Rheumatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, SpainDepartment of Rheumatology, AOU Careggi, 50134 Firenze, ItalyDepartment of Internal Medicine, Vall d’Hebron General Hospital, Universitat Autonoma de Barcelona, GEAS group, 08035 Barcelona, SpainDepartment of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, 28006 Madrid, SpainDepartment of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, ItalyDepartment of Rheumatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, SpainAntisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group’s cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The “ex-novo” occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies’ positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition.https://www.mdpi.com/2077-0383/8/11/2013antisynthetase syndromeantisynthetase antibodiesarthritismyositisinterstitial lung disease |