New phenalenone analogues with improved activity against Leishmania species

New phenalenone analogues with improved activity against Leishmania species

ABSTRACT: The in vitro activity against Leishmania spp. of five novel designed compounds, phenalenone derivatives, is described in this study. Previous works have shown that some phenalenones present leishmanicidal activity, some of which could induce programmed cell death events in L. amazonensis p...

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Bibliographic Details
Main Authors: Atteneri López-Arencibia, Carlos J. Bethencourt-Estrella, Mónica B. Freijo, María Reyes-Batlle, Ines Sifaoui, Desirée San Nicolás-Hernández, Grant McNaughton-Smith, Jacob Lorenzo-Morales, Teresa Abad-Grillo, José E. Piñero
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Phenalenones
Leishmania amazonensis
apoptosis-like
chemotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220310076

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