Low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysis
Abstract Background For acute ischaemic stroke patients, it is uncertain whether intravenous thrombolysis combined with statins might increase the therapeutic effect. Additionally, using high-intensity statins after thrombolysis may increase the risk of bleeding in patients. Asian stroke patients of...
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doaj-6b5e7778dc8f4456a80a7117ed92b6972021-06-13T11:29:51ZengBMCBMC Neurology1471-23772021-06-012111910.1186/s12883-021-02259-9Low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysisChaohua Cui0Yanbo Li1Jiajia Bao2Shuju Dong3Lijie Gao4Li He5Department of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityAbstract Background For acute ischaemic stroke patients, it is uncertain whether intravenous thrombolysis combined with statins might increase the therapeutic effect. Additionally, using high-intensity statins after thrombolysis may increase the risk of bleeding in patients. Asian stroke patients often take low-dose statins. It is speculated that reducing the dose of statins may improve the risk of bleeding. Methods Data from consecutive acute ischaemic stroke patients with intravenous thrombolysis were prospectively collected. Efficacy outcomes included NIHSS (National Institutes of Health Stroke Scale) score improvement at 7 days after admission and mRS (Modified Rankin Scale) improvement at 90 days. Safety outcomes included haemorrhage events (intracerebral haemorrhage and gastrointestinal haemorrhage) in the hospital and death events within 2 years. Results The study finally included 215 patients. The statin group had a higher percentage of NIHSS improvement at 7 days (p < 0.001) and a higher percentage of a favourable functional outcome (FFO, mRS < = 2) (p < 0.001) at 90 days. The statin group had a lower percentage of intracerebral haemorrhage (p < 0.001) and gastrointestinal haemorrhage (p = 0.003) in the hospital and a lower percentage of death events (p < 0.001) within 2 years. Logistic regression indicated that statin use was significantly related to NIHSS improvement (OR = 4.697, p < 0.001), a lower percentage of intracerebral haemorrhage (OR = 0.372, p = 0.049) and gastrointestinal haemorrhage (OR = 0.023, p = 0.016), and a lower percentage of death events (OR = 0.072, p < 0.001). Conclusion For acute ischaemic stroke patients after intravenous thrombolysis, the use of low-dose statins was related to NIHSS improvement at 7 days and inversely related to haemorrhage events in the hospital and death events within 2 years, especially for moderate stroke or noncardioembolic stroke patients.https://doi.org/10.1186/s12883-021-02259-9StrokeStatinsIntravenous thrombolysisEfficacy and safety outcome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chaohua Cui Yanbo Li Jiajia Bao Shuju Dong Lijie Gao Li He |
spellingShingle |
Chaohua Cui Yanbo Li Jiajia Bao Shuju Dong Lijie Gao Li He Low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysis BMC Neurology Stroke Statins Intravenous thrombolysis Efficacy and safety outcome |
author_facet |
Chaohua Cui Yanbo Li Jiajia Bao Shuju Dong Lijie Gao Li He |
author_sort |
Chaohua Cui |
title |
Low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysis |
title_short |
Low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysis |
title_full |
Low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysis |
title_fullStr |
Low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysis |
title_full_unstemmed |
Low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysis |
title_sort |
low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysis |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2021-06-01 |
description |
Abstract Background For acute ischaemic stroke patients, it is uncertain whether intravenous thrombolysis combined with statins might increase the therapeutic effect. Additionally, using high-intensity statins after thrombolysis may increase the risk of bleeding in patients. Asian stroke patients often take low-dose statins. It is speculated that reducing the dose of statins may improve the risk of bleeding. Methods Data from consecutive acute ischaemic stroke patients with intravenous thrombolysis were prospectively collected. Efficacy outcomes included NIHSS (National Institutes of Health Stroke Scale) score improvement at 7 days after admission and mRS (Modified Rankin Scale) improvement at 90 days. Safety outcomes included haemorrhage events (intracerebral haemorrhage and gastrointestinal haemorrhage) in the hospital and death events within 2 years. Results The study finally included 215 patients. The statin group had a higher percentage of NIHSS improvement at 7 days (p < 0.001) and a higher percentage of a favourable functional outcome (FFO, mRS < = 2) (p < 0.001) at 90 days. The statin group had a lower percentage of intracerebral haemorrhage (p < 0.001) and gastrointestinal haemorrhage (p = 0.003) in the hospital and a lower percentage of death events (p < 0.001) within 2 years. Logistic regression indicated that statin use was significantly related to NIHSS improvement (OR = 4.697, p < 0.001), a lower percentage of intracerebral haemorrhage (OR = 0.372, p = 0.049) and gastrointestinal haemorrhage (OR = 0.023, p = 0.016), and a lower percentage of death events (OR = 0.072, p < 0.001). Conclusion For acute ischaemic stroke patients after intravenous thrombolysis, the use of low-dose statins was related to NIHSS improvement at 7 days and inversely related to haemorrhage events in the hospital and death events within 2 years, especially for moderate stroke or noncardioembolic stroke patients. |
topic |
Stroke Statins Intravenous thrombolysis Efficacy and safety outcome |
url |
https://doi.org/10.1186/s12883-021-02259-9 |
work_keys_str_mv |
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