Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis
Abstract Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the g...
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Nature Publishing Group
2020-06-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-66816-x |
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English |
format |
Article |
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DOAJ |
author |
Fernanda Genre Javier Rueda-Gotor Sara Remuzgo-Martínez Verónica Pulito-Cueto Alfonso Corrales Verónica Mijares Leticia Lera-Gómez Virginia Portilla Rosa Expósito Cristina Mata Ricardo Blanco Javier Llorca Vanesa Hernández-Hernández Esther Vicente Cristina Fernández-Carballido María Paz Martínez-Vidal David Castro-Corredor Joaquín Anino-Fernández Carlos Rodríguez-Lozano Oreste Gualillo Juan Carlos Quevedo-Abeledo Santos Castañeda Iván Ferraz-Amaro Raquel López-Mejías Miguel Á. González-Gay |
spellingShingle |
Fernanda Genre Javier Rueda-Gotor Sara Remuzgo-Martínez Verónica Pulito-Cueto Alfonso Corrales Verónica Mijares Leticia Lera-Gómez Virginia Portilla Rosa Expósito Cristina Mata Ricardo Blanco Javier Llorca Vanesa Hernández-Hernández Esther Vicente Cristina Fernández-Carballido María Paz Martínez-Vidal David Castro-Corredor Joaquín Anino-Fernández Carlos Rodríguez-Lozano Oreste Gualillo Juan Carlos Quevedo-Abeledo Santos Castañeda Iván Ferraz-Amaro Raquel López-Mejías Miguel Á. González-Gay Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis Scientific Reports |
author_facet |
Fernanda Genre Javier Rueda-Gotor Sara Remuzgo-Martínez Verónica Pulito-Cueto Alfonso Corrales Verónica Mijares Leticia Lera-Gómez Virginia Portilla Rosa Expósito Cristina Mata Ricardo Blanco Javier Llorca Vanesa Hernández-Hernández Esther Vicente Cristina Fernández-Carballido María Paz Martínez-Vidal David Castro-Corredor Joaquín Anino-Fernández Carlos Rodríguez-Lozano Oreste Gualillo Juan Carlos Quevedo-Abeledo Santos Castañeda Iván Ferraz-Amaro Raquel López-Mejías Miguel Á. González-Gay |
author_sort |
Fernanda Genre |
title |
Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis |
title_short |
Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis |
title_full |
Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis |
title_fullStr |
Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis |
title_full_unstemmed |
Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis |
title_sort |
omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-06-01 |
description |
Abstract Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the genetic and functional implication of omentin in CV risk and subclinical atherosclerosis in a cohort of 385 axSpA patients. Subclinical atherosclerosis was evaluated by carotid ultrasound. Omentin rs12409609, in linkage disequilibrium with a polymorphism associated with CV risk, was genotyped in 385 patients and 84 controls. Serum omentin levels were also determined. omentin mRNA expression was assessed in a subgroup of individuals. Serum and mRNA omentin levels were lower in axSpA compared to controls. Low serum omentin levels were related to male sex, obesity, inflammatory bowel disease (IBD) and high atherogenic index. rs12409609 minor allele was associated with low omentin mRNA expression in axSpA. No association was observed with subclinical atherosclerosis at the genetic or functional level. In conclusion, in our study low omentin serum levels were associated with CV risk factors in axSpA. Furthermore, rs12409609 minor allele may be downregulating the expression of omentin. These data support a role of omentin as a CV risk biomarker in axSpA. |
url |
https://doi.org/10.1038/s41598-020-66816-x |
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doaj-6b5fb383f8884bf7ace58552d87fbe412021-06-20T11:42:17ZengNature Publishing GroupScientific Reports2045-23222020-06-011011810.1038/s41598-020-66816-xOmentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritisFernanda Genre0Javier Rueda-Gotor1Sara Remuzgo-Martínez2Verónica Pulito-Cueto3Alfonso Corrales4Verónica Mijares5Leticia Lera-Gómez6Virginia Portilla7Rosa Expósito8Cristina Mata9Ricardo Blanco10Javier Llorca11Vanesa Hernández-Hernández12Esther Vicente13Cristina Fernández-Carballido14María Paz Martínez-Vidal15David Castro-Corredor16Joaquín Anino-Fernández17Carlos Rodríguez-Lozano18Oreste Gualillo19Juan Carlos Quevedo-Abeledo20Santos Castañeda21Iván Ferraz-Amaro22Raquel López-Mejías23Miguel Á. González-Gay24Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALResearch group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALResearch group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALResearch group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALResearch group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALResearch group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALResearch group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALResearch group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALRheumatology Division, Hospital Comarcal de LaredoRheumatology Division, Hospital Comarcal de LaredoResearch group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALDepartment of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBERESP, IDIVALRheumatology Division, Hospital Universitario de CanariasRheumatology Division, Hospital Universitario de La Princesa, IIS-PrincesaRheumatology Division, Hospital Universitario de San JuanRheumatology Division, Hospital General Universitario de AlicanteRheumatology Division, Hospital General Universitario de Ciudad RealRheumatology Division, Hospital General Universitario de Ciudad RealRheumatology Division, Hospital Universitario de Gran Canaria Dr. NegrínSERGAS and IDIS, The NEIRID Group, Santiago University Clinical HospitalRheumatology Division, Hospital Universitario de Gran Canaria Dr. NegrínRheumatology Division, Hospital Universitario de La Princesa, IIS-PrincesaRheumatology Division, Hospital Universitario de CanariasResearch group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALResearch group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVALAbstract Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the genetic and functional implication of omentin in CV risk and subclinical atherosclerosis in a cohort of 385 axSpA patients. Subclinical atherosclerosis was evaluated by carotid ultrasound. Omentin rs12409609, in linkage disequilibrium with a polymorphism associated with CV risk, was genotyped in 385 patients and 84 controls. Serum omentin levels were also determined. omentin mRNA expression was assessed in a subgroup of individuals. Serum and mRNA omentin levels were lower in axSpA compared to controls. Low serum omentin levels were related to male sex, obesity, inflammatory bowel disease (IBD) and high atherogenic index. rs12409609 minor allele was associated with low omentin mRNA expression in axSpA. No association was observed with subclinical atherosclerosis at the genetic or functional level. In conclusion, in our study low omentin serum levels were associated with CV risk factors in axSpA. Furthermore, rs12409609 minor allele may be downregulating the expression of omentin. These data support a role of omentin as a CV risk biomarker in axSpA.https://doi.org/10.1038/s41598-020-66816-x |